Search results for "Uso"
showing 10 items of 1400 documents
The oral KIF11 inhibitor 4SC‐205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma …
2021
Inhibidor de KIF11; Terapias dirigidas; Metástasis Inhibidor de KIF11; Teràpies dirigides; Metàstasi KIF11 inhibitor; Targeted therapies; Metastasis In summary, our study provides a rationale for the future therapeutic integration in clinical trials of 4SC-205, an structurally distinct oral KIF11 inhibitor that shows potent antitumor activity in multiple preclinical neuroblastoma models and sensitizes neuroblastoma cells to standard chemotherapy and specific neuroblastoma-targeted therapies. The financial support for this research was provided by Instituto de Salud Calos III (PI20/00530 to Miguel F. Segura; PI20/01107 to Rosa Noguera; PI17/02248 and CPII18/00027 to Anna Santamaria; PI19/013…
Los nuevos medios de comunicación: comentario
1987
Urban growth (1956-2012) and soil sealing in the metropolitan area of Valencia (Eastern Spain)
2019
[EN] The aim of this study is to understand the urban growth dynamics from the mid-1950s to 2012 in the Metropolitan Area of Valencia, eastern Spain, and its impact on soils. The study area is a very interesting example of the many changes in land use and land cover in the landscape of Mediterranean alluvial plains. The analysis of urban growth was based on photo interpretation of aerial photographs and GIS based methodology. At a detailed scale (1:10,000), results show that there has been a highly dynamic process produced by the extent of land developed as urban area. In 1956 only 3,441 hectares (9.3% of the overall study area) were occupied by urban use. In 2012 the total sealed surface w…
New insights into the gut microbiome in loggerhead sea turtles Caretta caretta stranded on the Mediterranean coast
2019
Caretta caretta is the most common sea turtle species in the Mediterranean Sea. The species is threatened by anthropomorphic activity that causes thousands of deaths and hundreds of strandings along the Mediterranean coast. Stranded turtles are often cared for in rehabilitation centres until they recover or die. The objective of this study was to characterize the gut microbiome of nine sea turtles stranded along the Sicilian coast of the Mediterranean Sea using high-throughput sequencing analysis targeting V3–V4 regions of the bacterial 16S rRNA gene. Stool samples were collected from eight specimens hosted in the recovery centre after a few days of hospitalization (under 7) and from one ho…
MUTILAZIONI GENITALI FEMMINILI TRA PASSATO E PRESENTE
2014
John Miltonin avioliittoa, nuorukaisten koulutusta ja ilmaisuvapautta koskevat uudistusvaatimukset 1640-luvun Englannin sisällissodan aikan
2001
Bioactivity of bioceramic materials used in the dentin-pulp complex therapy : a systematic review
2019
Este es el artículo que se ha publicado de forma definitiva en: https://www.mdpi.com/1996-1944/12/7/1015 Dentistry-applied bioceramic materials are ceramic materials that are categorized asbioinert, bioactive and biodegradable. They share a common characteristic of being specificallydesigned to fulfil their function; they are able to act as root canal sealers, cements, root repair or fillingmaterials. Bioactivity is only attributed to those materials which are capable of inducing a desiredtissue response from the host. The aim of this study is to present a systematic review of availableliterature investigating bioactivity of dentistry-applied bioceramic materials towards dental pulp stemcel…
Abuso di funzioni costituzionali e responsabilità penale
2013
Minori autori di reati sessuali: un’analisi prelimiare sui casi giudicati dal tribunale per i minorenni di Palermo negli anni 2005-2009
2012
L’allarme sociale in ordine agli abusi sessuali sui minori è accresciuto negli anni unitamente alla consapevolezza dell’importanza della tutela del minore e del valore fondamentale delle sue relazioni nel corso dello sviluppo. Il presente studio intende essere un contributo di conoscenza su una specifica categoria di abusanti: i minorenni. Uno studio delle peculiarità di tale fenomeno è premessa indispensabile per predisporre idonee ed efficaci strategie di trattamento. Al fine di identificare il numero e le caratteristiche dei minori abusanti si è proceduto a consultare i fascicoli del Tribunale per i Minorenni di Palermo relativi ad un periodo compreso fra il 2005 e il 2009. Tale indagine…
A new evolutionary paradigm for the Parkinson disease gene DJ-1.
2006
The DJ-1 gene is extensively studied because of its involvement in familial Parkinson disease. DJ-1 belongs to a complex superfamily of genes that includes both prokaryotic and eukaryotic representatives. We determine that many prokaryotic groups, such as proteobacteria, cyanobacteria, spirochaetes, firmicutes, or fusobacteria, have genes, often incorrectly called "Thij," that are very close relatives of DJ-1, to the point that they cannot be clearly separated from the eukaryotic DJ-1 genes by phylogenetic analyses of their sequences. In addition, and contrary to a previous study that suggested that DJ-1 genes were animal specific, we show that DJ-1 genes are found in at least 5 of the 6 ma…