Search results for "Ustic"

Filosofía, ciencia y biología sintética

2016

En este artículo se defiende la necesidad de que el actor de la ciencia, el científico, disponga de suficiente formación filosófica como para analizar críticamente el alcance de su propia actividad especializada, análisis que debiera empezar por entender qué es eso a lo que llamamos ciencia. Se ejemplifica la necesidad de tal formación recurriendo a la biología sintética. Se muestran los peligros que se corren de la derivación hacia campos no científicos si el científico está imbuido de una ciencia fáustica orientada a la obtención del producto –el ente biológico sintético– disminuyendo veladamente el interés por estudiar el mismo desde la óptica de la ciencia prometeica, aquella que se apr…

Observation of elastic anisotropy in strained optical nanofibers using Brillouin spectroscopy

2019

Optical nanofibers (ONFs) are excellent nanophotonic platforms for many applications such as optical sensing, quantum photonics, and nonlinear optics, due to both tight optical confinement and their evanescent field. From an acoustic viewpoint, it has recently been reported the observation of a new class of Brillouin acoustic resonances in optical nanofibers, including hybrid shear/longitudinal acoustic waves (HAWs) and surface acoustic waves (SAWs) [1–2]. It has been later shown that, under axial tensile strain, the Brillouin frequency shifts (BFS) of these elastic resonances are fundamentally different from that of standard optical fibers [3]. This is principally due to the hybrid nature …

Music style not only modulates the auditory cortex, but also motor related areas

2021

The neuroscience of music has recently attracted significant attention, but the effect of music style on the activation of auditory-motor regions has not been explored. The aim of the present study is to analyze the differences in brain activity during passive listening to non-vocal excerpts of four different music genres (classical, reggaeton, electronic and folk). A functional magnetic resonance imaging (fMRI) experiment was performed. Twenty-eight participants with no musical training were included in the study. They had to passively listen to music excerpts of the above genres during fMRI acquisition. Imaging analysis was performed at the whole-brain-level and in auditory-motor regions …

Absence of Early Neuronal Death in the Olivocochlear System Following Acoustic Overstimulation

2015

This study was conducted to examine possible effects of noise trauma on olivocochlear (OC) neurons. Anesthetized rats were exposed to a continuous 10 kHz pure tone at 120 dB sound pressure level for 2 hrs. The effects of treatment were verified by recordings of auditory brainstem response and distortion product otoacoustic emission. Three or 8 days after acoustic trauma, rats received unilateral injections of an aqueous solution of the retrograde neuronal tracer Fluorogold (FG) into the scala tympani to identify OC neurons (OCN). Five days after FG injection, brains were perfusion-fixed, and brainstem sections were cut and analyzed with respect to FG-labeled neurons. We found that, in both …

ERa dimerization: a key factor for the weak estrogenic activity of an ERa modulator unable to compete with estradiol in binding assays

2016

PMID: 27400858; International audience; AbstractEstrothiazine (ESTZ) is a weak estrogen sharing structural similarities with coumestrol. ESTZ failed to compete with [3H]17β-estradiol ([3H]17β-E2) for binding to the estrogen receptor α (ERα), questioning its ability to interact with the receptor. However, detection by atomic force spectroscopy (AFS) of an ESTZ-induced ERα dimerization has eliminated any remaining doubts. The effect of the compound on the proliferation of ERα-positive and negative breast cancer cells confirmed the requirement of the receptor. The efficiency of ESTZ in MCF-7 cells was weak without any potency to modify the proliferation profile of estradiol and coumestrol. Gro…

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Sy…

2021

Abstract Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR ( path_MMR ) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1 , path_MSH2 , path_MSH6 , and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and…

Quantification of propagating and standing surface acoustic waves by stroboscopic X-ray photoemission electron microscopy.

2018

The quantification of surface acoustic waves (SAWs) in LiNbO3 piezoelectric crystals by stroboscopic X-ray photoemission electron microscopy (XPEEM), with a temporal smearing below 80 ps and a spatial resolution below 100 nm, is reported. The contrast mechanism is the varying piezoelectric surface potential associated with the SAW phase. Thus, kinetic energy spectra of photoemitted secondary electrons measure directly the SAW electrical amplitude and allow for the quantification of the associated strain. The stroboscopic imaging combined with a deliberate detuning allows resolving and quantifying the respective standing and propagating components of SAWs from a superposition of waves. Furth…

[Qualité attendue contre qualité perçue : arbitrage avec les prix]

2000

International audience; Cet article rend compte d'une étude menée afin de comparer le comportement des consommateurs qui doivent choisir des produits sous contrainte économique, selon deux conditions différentes : quand la qualité perçue est basée sur une attente générée par des images fabriquées et, à l'inverse, quand la qualité perçue est basée sur l'expérience sensorielle en présence d'images fabriquées. Les participants de l'expérience ont été choisis au hasard, dotés d'un budget réel et placés dans cinq situations différentes de prix/budget. Ils ont formulé leurs choix parmi six jus d'orange dans chaque situation prix/budget. Ce travail a été réalisé pour les deux conditions différente…

2021

AbstractAs the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity in its attenuation of economic, physical, and legal barriers and effectively enabled many individuals from groups that have traditionally been underrepresented to join and participate. A number of studies have outlined how moving online made it possible to gather a more global community and has increased opportunities for individuals with various constraints, e.g., caregiving responsibilities.Yet, the mere existence of online conferences is no guarantee that everyone can attend and participate meaningfully. In fact, many elements of a…

Policiers, gendarmes et signalement descriptif. Représentations, apprentissages et pratiques d'une nouvelle technique de police judiciaire, en France…

2006

À partir des années 1880, les nouveaux procédés d’identification développés par Alphonse Bertillon à la Préfecture de police de Paris représentent des moyens modernes et efficaces de police judiciaire face à une criminalité perçue comme irrésistible. Parmi ceux-ci, le signalement descriptif, ou « portrait parlé », est réputé permettre la reconnaissance infaillible d’un individu dont les traits du visage auraient été minutieusement décrits par cette technique particulière. Fait notable, sans doute inédit et sans équivalent alors, cette technique est enseignée aux divers acteurs de la police française – policiers de la Préfecture de police, de la Sûreté générale, mais aussi gendarmes et garde…