Search results for "VALIDATION"
showing 10 items of 620 documents
Body image during sexual activity in the population of Polish adult women
2020
Introduction. Recently it has been shown that body image during sexual activities is a better predictor of the diversity of sexual experience than body image as a psychological trait. To measure contextual body image (as a state) the Body Exposure During Sexual Activity Questionnaire (BESAQ) was developed. Material and methods. 845 women aged 18-55 years were included in the study. The original model was first translated into Polish and consulted to create the version to be further validated. The original model was tested using confirmatory factor analysis (CFA). The population was divided in two equal groups – group 1 was used for exploratory factor analysis. Discriminant and convergent va…
PEM FC Single Cell Based on a 3-D Printed Plastic Housing and Experimental Validation with the Mathematical Model
2018
Abstract This paper presents the design, modelling, and testing of a PEM single fuel cell based on the use of 3D printing. The design of the housings was made of SolidWorks, while MATLAB/SIMULINK were used to model performance. The fabricated cell performed satisfactorily with no leaks of gas, showing that the 3D printing method can be used in the additive manufacturing of fuel cells thus leading to significant cost savings.
Prediction of Disease–lncRNA Associations via Machine Learning and Big Data Approaches
2021
This chapter introduces long non-coding RNAs and their role in the occurrence and progress of diseases. The discovery of novel lncRNA-disease associations may provide valuable input to the understanding of disease mechanisms at the lncRNA level, as well as to the detection of biomarkers for disease diagnosis, treatment, prognosis, and prevention. Unfortunately, due to costs and time complexity, the number of possible disease-related lncRNAs verified by traditional biological experiments is very limited. Computational approaches for the prediction of potential disease-lncRNA associations can effectively decrease the time and cost of biological experiments. We first review the main computatio…
Integrative Gene Expression and Metabolic Analysis Tool IgemRNA
2022
ABSTRACTGenome scale metabolic modelling is widely used technique to research metabolism impacts on organism’s properties. Additional omics data integration enables a more precise genotype-phenotype analysis for biotechnology, medicine and life sciences. Transcriptome data amounts rapidly increase each year. Many transcriptome analysis tools with integrated genome scale metabolic modelling are proposed. But these tools have own restrictions, compatibility issues and the necessity of previous experience and advanced user skills. We have analysed and classified published tools, summarized possible transcriptome pre-processing, and analysis methods and implemented them in the new transcriptome…
Validation of Semantic Analyses of Unstructured Medical Data for Research Purposes
2019
BACKGROUND: In secondary data there are often unstructured free texts. The aim of this study was to validate a text mining system to extract unstructured medical data for research purposes. METHODS: From a radiological department, 1,000 out of 7,102 CT findings were randomly selected. These were manually divided into defined groups by 2 physicians. For automated tagging and reporting, the text analysis software Averbis Extraction Platform (AEP) was used. Special features of the system are a morphological analysis for the decomposition of compound words as well as the recognition of noun phrases, abbreviations and negated statements. Based on the extracted standardized keywords, findings rep…
Smart Technologies for Improved Software Maintenance
2015
Steadily increasing complexity of software systems makes them difficult to configure and use without special IT knowledge. One of the solutions is to improve software systems making them “smarter”, i.e. to supplement software systems with features of self-management, at least partially. This paper describes several software components known as smart technologies, which facilitate software use and maintenance. As to date smart technologies incorporate version updating, execution environment testing, self-testing, runtime verification and business process execution. The proposed approach has been successfully applied in several software projects.
A Case Study of Open Source Software Development in Proteomic Area: The LIMS ePims
2008
The objective of this paper is to provide an illustrative feedback on development of Open Source software among several partners. We describe the first stage of the design of a specific software package, namely a customized Laboratory Information Management System (LIMS) for biology applications. This software package is structured in several modules which are reusable and can be customized for other applications. In this paper, we address the problem of multi-licensing for the same software tools due to the participation of several partners, the reuse of code source, and the subsequent distribution of this produced software.
Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mous…
2013
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progression was characterized by two principal pathogenic mechanisms. Initially, AE expression modified the lineage potential of haematopoietic stem cells (HSCs), resulting in the selective expansion of the myeloid compartment at the expense of normal erythro- and lymphopoiesis. This lineage skewing was foll…
Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the…
2021
European Community's Seventh Framework Program, European Commission [HEALTH-F2-2009-241909]; Scientific and Technological Research Council of Turkey, 2219 International Postdoctoral Research Fellowship Program; Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, and PI19/024)...
Reliability and Validity of The Finnish Version of The Boston Carpal Tunnel Questionnaire among Surgically Treated Carpal Tunnel Syndrome Patients
2019
Background and Aims: The Boston Carpal Tunnel Questionnaire is the most commonly used outcome measure in the assessment of carpal tunnel syndrome. The purpose of this study was to translate the original Boston Carpal Tunnel Questionnaire into Finnish and validate its psychometric properties. Materials and Methods: We translated and culturally adapted the Boston Carpal Tunnel Questionnaire into Finnish. Subsequently, 193 patients completed the Finnish version of the Boston Carpal Tunnel Questionnaire, 6-Item CTS Symptoms Scale, and EuroQol 5 Dimensions 12 months after carpal tunnel release. The Boston Carpal Tunnel Questionnaire was re-administered after a 2-week interval. We calculated cons…