Search results for "VALUATION"

WORKING CAPITAL AS AN ENTERPRISE VALUE ASSESSMENT TOOL

2019

The valuation of an entity in off-exchange transactions involves the use of different techniques. Nevertheless, none of them guarantees the most accurate result. Therefore, it is very difficult to choose one evaluation method. Both investors, corporate managers, financial professionals, portfolio managers, and securities analysts should have a basic understanding of the process of evaluating companies. To that end, professionals recommend evaluating a company’s financial reports to detect its financial position and solvency. According to the methods of financial analysis, working capital is one of the solvency ratios, which describes the value of resources that remain after the company’s cu…

Sorafenib perpetuates cellular anti-cancer effector functions by modulating the cross talk between macrophages and natural killer cells.

2012

Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor-directed natural killer (NK) cell responses. In vivo experiments were conducted with sorafenib (25 mg/kg)-treated C57BL/6 wildtype as well as hepatitis B virus (HBV) and lymphotoxin transgenic mice with and without HCC. Monocyte-derived Mϕ or tumor-associated macrophages (TAM) isolated from HCC tissue were treated with sorafenib (0.07-5.0 μg/mL) and cocultured with autologous NK cells. Mϕ and NK cell activation was analyzed …

Using privacy-transformed speech in the automatic speech recognition acoustic model training

2020

Automatic Speech Recognition (ASR) requires huge amounts of real user speech data to reach state-of-the-art performance. However, speech data conveys sensitive speaker attributes like identity that can be inferred and exploited for malicious purposes. Therefore, there is an interest in the collection of anonymized speech data that is processed by some voice conversion method. In this paper, we evaluate one of the voice conversion methods on Latvian speech data and also investigate if privacy-transformed data can be used to improve ASR acoustic models. Results show the effectiveness of voice conversion against state-of-the-art speaker verification models on Latvian speech and the effectivene…

Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixed-mode liquid chromatography with quadrupole time-of-fligh…

2018

An analytical method based on liquid chromatography with quadrupole time-of-flight mass spectrometry has been developed for the simultaneous determination of six aminoglycoside antibiotics in honey. The sample pretreatment included extraction with aqueous trichloroacetic acid followed by solid-phase extraction on Strata-X polymeric reversed phase cartridges. Liquid chromatography separation was performed on an Obelisc R zwitterionic type mixed-mode column. An ionBooster™ heated electrospray source was used and showed enhanced ionization efficiency in comparison to a conventional electrospray source. The observed signal enhancement ranged from 3- (neomycin) to 16-fold (gentamicin C1). A data…

Genetic contribution in sporadic thoracic aortic aneurysm? Emerging evidence of genetic variants related to TLR-4-mediated signaling pathway as risk …

2015

Abstract Sporadic thoracic aortic aneurysms (TAA) and dissections are one of the major causes of morbidity and mortality worldwide, especially in those older than 65 years. The presentation of TAA is varied and often silent. Thus, sporadic TAA detection is often fortuitous, with identification occurring during a routine physical examination or during an unrelated medical evaluation. Once suspected, confirmation by imaging clinical approaches is needed to allow the choose of the unique treatments for TAA, namely the surgery procedures, including elective surgery or endovascular repair before the onset of catastrophic and fatal complications, such as dissection or rupture. At present, there a…

Investing in Sports Facilities: The Italian Situation Toward an Olympic Perspective. Confidence Intervals for the Financial Analysis of Pools

2015

Given the current economic crisis, there is a lack of investments also for public sport facilities, which are vital to the urban quality of the city and the quality of life of its citizens. The situation is serious in Italy, especially after the failure of public policies for funding of major events (World Cup, 1990; Winter Olympics, 2006). Some recent laws (147/2013) have revived the sector with particular atten-tion to the medium size facilities but have neglected the small structures that represent the basic activities. In case of the latter, a convergence of objectives is needed between public administrations and private investors. Therefore, public au-thorities should think in terms of…

Effect of a common exercise programme with an individualised progression criterion based on the measurement of neuromuscular capacity versus current …

2021

IntroductionHigh-load resistance training has shown positive effects in pain and function in lower limb tendinopathies. However, some authors suggest that current exercise programmes produce an increase in tolerance to load and exercise in general but without fixing some existing issues in tendinopathy. This may indicate the need to include training aspects not currently taken into account in the current programmes. The main objective of this study will be to compare the effect of a common exercise protocol for the three predominant lower limb tendinopathies (Achilles, patellar and gluteal), based on an individualised control of the dose and training of specific aspects of the neuromuscular…

Évaluer les effets des stages pour publics "en difficulté", des problèmes qui ne sont pas seulement d'ordre méthodologique ... réflexions à partir d'…

1996

How to assess the impact of courses aimed at problem-people : a discussion of a case-study In the context of high unemployment, a considerable course market has developped but their impact on finding a job remains quite uncertain. This paper provides an evaluation of a course aimed at problem job seekers, carried out in Bourgogne (middle-east region). Course attendance is most likely to be linked to job hunting and the setting up of more elaborate career plans. It looks as if other psychological changes are negligeable. Moreover, this assessment raises the question of the possible evil effects of such development on a more general level.

Évaluer les effets des stages pour publics "en difficulté" : réflexions à partir d'une étude de cas

1995

Physical Fitness Evaluation of School Children in Southern Italy: A Cross Sectional Evaluation

2018

The aim of this work was to evaluate the fitness levels of different physical components in schoolchildren in southern Italy and identify age-related effects of physical performance. One hundred and fifty-four schoolchildren with ages ranging between 6 and 10 years (age 8.1 ± 1.45 years; 33.70 ± 10.25 kg; 131.50 ± 13.60 cm) were recruited for the investigation. Each scholar underwent a fitness-test battery composed of five elements. A Hand-Grip Strength Test to assess the strength of the hand muscles, a Standing Broad Jump Test to assess lower body explosive strength, a Sit-Up Test to exhaustion to evaluate abdominal muscular endurance, a 4 × 10-m Shuttle Run Test to assess agility, and a 2…