Search results for "VALUATION"

Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.

2006

Gaining knowledge on the metabolism of a drug, the enzymes involved and its inhibition or induction potential is a necessary step in pharmaceutical development of new compounds. Primary human hepatocytes are considered a cellular model of reference, as they express the majority of drug-metabolising enzymes, respond to enzyme inducers and are capable of generating in vitro a metabolic profile similar to what is found in vivo. However, hepatocytes show phenotypic instability and have a restricted accessibility. Different alternatives have been explored in the past recent years to overcome the limitations of primary hepatocytes. These include immortalisation of adult or fetal human hepatic cel…

Clinical and magnetic resonance imaging predictors of disease progression in multiple sclerosis: a nine-year follow-up study.

2014

Objective: The objective of this paper is to identify clinical or magnetic resonance imaging (MRI) predictors of long-term clinical progression in a large cohort of multiple sclerosis (MS) patients. Methods: A total of 241 relapsing–remitting (RR) MS patients were included in a nine-year follow-up (FU) study. The reference MRIs were acquired at baseline (BL) as part of a multicenter, cross-sectional, clinical-MRI study. Volumetric MRI metrics were measured by a fully automated, operator-independent, multi-parametric segmentation method. Clinical progression was evaluated as defined by: conversion from RR to secondary progressive (SP) disease course; progression of Expanded Disability Status…

Anxiety and subjective quality of life preoperatively and 4 months after reduction mammaplasty.

2005

Abstract Objective The aim of this study was to evaluate the development of anxiety, psychological distress, and subjective quality of life on the basis of the criteria of satisfaction and expectations in a group of women who had undergone reduction mammaplasty for cosmetic reasons. Method The population consisted of 20 women who had requested breast reduction treatment [mean age, 34.70 (±10.94)] for cosmetic reasons. After being informed of the purpose of the study and after giving their written consent, the subjects took part in a psychological examination conducted at two different times (T1, initial medical consultation; T2, 4 months after surgery). At each of these stages, the psycholo…

Controlled education of patients after stroke (ceops)-nurse-led multimodal and long-term interventional program involving a patient''s caregiver to o…

2018

Background Setting up a follow-up secondary prevention program after stroke is difficult due to motor and cognitive impairment, but necessary to prevent recurrence and improve patients’ quality of life. To involve a referent nurse and a caregiver from the patient’s social circle in nurse-led multimodal and long-term management of risk factors after stroke could be an advantage due to their easier access to the patient and family. The aim of this study is to compare the benefit of optimized follow up by nursing personnel from the vascular neurology department including therapeutic follow up, and an interventional program directed to the patient and a caregiving member of their social circle,…

Functional Evaluation of Patients with Implanted Pacemakers

1980

Because of the knowledge that his life is dependent on the pacemaker and due to the uncertainty of some clinical results, the paced patient needs a guide to return to society.

Trust and mistrust when students read multiple information sources about climate change

2011

Abstract The present study investigated how undergraduates judged the trustworthiness of different information sources that they read about climate change. Results showed that participants ( N  = 128) judged information from textbook and official documents to be more trustworthy than information from newspapers and a commercial agent. Moreover, participants put most emphasis on content and least emphasis on date of publication when judging document trustworthiness. When judging the trustworthiness of the textbook, they emphasized criteria differently than when evaluating other types of documents. Results also indicated that readers low in topic knowledge were more likely to trust less trust…

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Bu…

2020

Background\ud \ud Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 on the burden of cirrhosis and its trends since 1990, by cause, sex, and age, for 195 countries and territories.\ud \ud \ud \ud Methods\ud \ud We used data from vital registrations, vital registration samples, and verbal autopsies to estimate mortality. We modelled prevalence of total, compensated, and decompensated cirrhosis on the bas…

Real-life evaluation of a rapid extraction-free SARS-CoV-2 RT-PCR assay (COVID-19 PCR Fast-L) for the diagnosis of COVID-19.

2021

Ocena wiarygodności internetowych serwisów wybranych polskich wyższych uczelni niepublicznych

2019

Celem artykułu jest dokonanie i przedstawienie oceny wiarygodności internetowych serwisów wybranych polskich wyższych uczelni niepublicznych. Koncepcja, metody badań: Sięgając do definicji terminów związanych z pojęciem wiarygodność odniesiono je do serwisów internetowych. Na tej podstawie stworzono konceptualne ramy oceny wiarygodności dla takich serwisów. Ramy te posłużyły do oceny wiarygodności internetowych serwisów wybranych wyższych uczelni niepublicznych w Polsce z wykorzystaniem metody sondażowej i oryginalnego narzędzia. Ranking wiarygodności badanych serwisów internetowych utworzono wykorzystując metodę TOPSIS. Wyniki i wnioski: W artykule pokazano, że zestaw cech i kryteriów używ…

Technical-economical evaluation for distributed storage applications. An Italian case study for a medium-scale public facility

2014

Time-of-use energy cost management involves the use of storage by customers to reduce their electricity bills. This can be accomplished by charging the storage during off-peak time periods, when electricity energy prices are low, and discharging it during times when on-peak energy prices are applied. This article addresses the question whether it is economically viable to install medium-scale distributed storage devices in the power system designed to lower the electricity cost for a customer-side application, assuming flexible electricity tariffs. The technical/economical evaluation is carried out referring to Lithium ion (Li-ion), Sodium Sulphur (NaS) and Vanadium Redox Battery (VRB) tech…