Search results for "VAST"

Talouspoliittisen päätöksenteon vuorovaikutteisuus ja sen yksilölle tarjoamat strategiset mahdollisuudet : tapaustutkimus Hans Henrik Boijen toiminna…

2003

Conflicting conceptualisations of ‘democracy’ in the German Bundestag during the anti-nuclear demonstrations, 1995-2001

2018

A vigorous anti-nuclear movement emerged in Germany in the mid 1990s, when spent nuclear fuel elements began to be transported to the interim storage facility in Gorleben, Lower Saxony. Resistance to nuclear transportation continued to grow in strength throughout the 1990s. The protests expressed people’s distrust and lack of confidence in political institutions and decision-making processes. In the German Bundestag, these events relating to Gorleben caused significant political struggles over the principles and meanings of German democracy. Parliamentarians voiced competing counterarguments about the legitimacy of these demonstrations, on the one hand, and the legitimacy of the nuclear ene…

Hauskasti puvuttomina : burleskin esteettisen vastarinnan traditio ja ilmiö Suomessa

2011

Tutkielmassani tarkastelen burleskin nykyilmiötä suhteessa sen historiallisiin juuriin, tyyliin ja traditioon esteettisen vastarinnan näkökulmasta etsien siitä vastakulttuurisia yhdessä nauramisen elementtejä. Tutkin, mitä historiallisten burleskien ja karnevalistisuuden piirteistä nykyilmiö yhä kantaa mukanaan, ja miten nykyburleski uudenlaisena, yhteisöllisenä, yksilöllisenä, heterogeenisenä, uudistavana ja uudistuvana esteettisen vastakulttuurin muotona liittyy erilaisten strategioiden kautta osaksi burleskin traditiota. Näkökulmani on useimpien aihetta käsittelevien tutkimusten naisnäkökulmasta poiketen laajemmin sukupuolen representaatioita, murroksia ja tulkintoja, sekä inhimillistä n…

Effect of hypolipidemic treatment on emerging risk factors in mixed dyslipidaemia: a randomized pilot tria

2013

Background The effects of different hypolipidemic treatment strategies on emerging atherosclerosis risk factors remain unknown. Materials and methods This is a prespecified analysis of a prospective, randomized, open-label, blinded end point (PROBE) study (ClinicalTrials.gov identifier: NCT01010516). Patients (n = 100) with mixed dyslipidaemia on a standard statin dose who had not achieved lipid targets were randomized to switch to the highest dose of rosuvastatin (40 mg/day) or to add-on-statin extended release nicotinic acid (ER-NA)/laropiprant (LRPT) or to add-on-statin micronized fenofibrate for a total of 3 months. Results Following 3 months of treatment, low-density lipoprotein (LDL) …

Lovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaks.

2006

Abstract Purpose: 3-hydroxy-3-methylglutaryl CoA reductase inhibitors (statins) are frequently used lipid-lowering drugs. Moreover, they are reported to exert pleiotropic effects on cellular stress responses, proliferation, and apoptosis. Whether statins affect the sensitivity of primary human cells to ionizing radiation (IR) is still unknown. The present study aims at answering this question. Experimental Design: The effect of lovastatin on IR-provoked cytotoxicity was analyzed in primary human umbilical vein endothelial cells (HUVEC). To this end, cell viability, proliferation, and apoptosis as well as DNA damage–related stress responses were investigated. Results: The data show that lova…

The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardio…

2013

Background: We assessed the influence of atorvastatin on selected indicators of an inflammatory condition, left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy (DCM). Methods. We included 68 DCM patients with left ventricular ejection fraction (LVEF) ≤40% treated optimally in a prospective, randomized study. They were observed for 5 years. Patients were divided into two groups: patients who were commenced on atorvastatin 40 mg daily for two months followed by an individually matched dose of 10 or 20 mg/day (group A), and patients who were treated according to current recommendations without statin therapy (group B). Results: After 5-year follow-u…

Neurosteroidogenesis in Rat Retinas

2002

Neurosteroids (steroids synthesized in the CNS) function by modulating neurotransmission. To establish an experimental model for investigation of neurosteroid synthesis and regulation, independent of blood-borne steroids, we examined the steroidogenic activity of isolated rat retinas. We identified progesterone, pregnenolone, dehydroepiandrosterone, desoxycorticosterone, 3 alpha,5 alpha-tetrahydrodesoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone, 17-hydroxyprogesterone, and 17-hydroxypregnenolone together with their esterified forms. As pregnenolone is the precursor of all steroids, its formation was studied in detail as an index of a steroid-synthesizing tissue. Pregnenolon…

Reunoillakin on tilaa

2018

The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide

2002

Ras-homologous GTPases are involved in the regulation of genotoxic stress-induced gene expression and cell death. Since they need C-terminal isoprenylation for correct intracellular localization and function, we investigated whether depletion of cells from isopren precursor moieties using the HMG-CoA reductase inhibitor lovastatin affects cellular sensitivity to DNA damaging drugs. Here we show that lovastatin renders cells highly resistant to the tumor-therapeutic compound doxorubicin. Desensitization by lovastatin was reverted by co-treatment with GGPP indicating that inhibition of protein geranylgeranylation is involved in acquired doxorubicin resistance. Lovastatin does not influence ce…

Reminders of responsibility : Journalism ethics codes in Western Europe

2022

Journalistic codes of ethics articulate conventions of professionalism as it is understood in Western democracies. Codes of ethics combine theoretical and applied ethics, defining the duties (e.g., service of the public, respect for human dignity, etc.) and offering practical instructions for information gathering, processing, and publishing. Codes of ethics do not solve ethical dilemmas but oblige journalists toward moral reasoning and give advice for making the right decisions. The codes of ethics created for traditional media have become insufficient in the current digital media era. The internet is global, as is the public, and increasingly, also the practice of journalism. The global i…