Search results for "VAST"
showing 10 items of 918 documents
History in corporate social responsibility : Reviewing and setting an agenda
2018
The integration of historical reasoning and corporate social responsibility (CSR) theorising has recently received remarkable cross-disciplinary attention by business historians and CSR scholars. But has there been a meaningful interdisciplinary conversation? Motivated by this question that presumes significant limitations in the current integration, I survey existing research for the purpose of sketching and shaping historical CSR studies, ie an umbrella that brings together diverse approaches to history and CSR theorising. Drawing from the recent efforts to establish historical methodologies in organisation studies, I first reconcile discrepant disciplinary and field-level traditions to c…
No egļu skujām iegūto poliprenolu nozīme atorvastatīna izraisītu muskuļu darbības traucējumu novēršanā žurkām
2015
Statīni, kā seruma lipīdus reducējoši līdzekļi, spēj mazināt koronāro un cerebrovaskulāro slimību progresiju. Statīni, inhibējot HMG-CoA reduktāzi, samazina holesterīna un arī poliprenolu līmeni, kas varētu veicināt muskuļu sāpju, miopātijas un rabdomiolīzes attīstību. Darba mērķis ir novērtēt no egļu skujām izdalīto poliprenolu, atorvastatīna, šo vielu kombinācijas efektus dažādos ar motoro funkciju analizējošos farmakoloģiskos testos. Darba rezultāti rāda, ka satvēriena spēka un trakcijas testā atorvastatīns 80 mg/kg samazināja žurku muskuļu spēku. Satvēriena testā poliprenoli 20 mg/kg un trakcijas testā poliprenoli 1,10,20 mg/kg protektēja atorvastatīna izraisīto muskuļu spēka samazināju…
Inbreeding does not alter the response to an experimental heat wave in a freshwater snail
2019
Global climate change affects natural populations of many species by increasing the average temperature and the frequency of extreme weather events (e.g. summer heat waves). The ability of organisms to cope with these environmental changes can, however, depend on their genetic properties. For instance, genetic load owing to inbreeding could alter organisms’ responses to climate change-mediated environmental changes but such effects are often overlooked. We investigated the effects of an experimental heat wave (25°C versus 15°C) on life history (reproduction, size) and constitutive immune defence traits (phenoloxidase-like and antibacterial activity of haemolymph) in relation to inbreeding b…
Training programme for novice physical activity instructors using Teaching Personal and Social Responsibility (TPSR) model : a programme development …
2021
Previous research indicates that programmes employing Hellison?s Teaching Personal and Social Responsibility (TPSR) model in physical activity have had a positive impact on youth development by increasing participants? positive values, autonomy, life skills, and prosocial behaviour. Despite encouraging results of the effects of TPSR-based programmes, there remains lack of research on the effective content of these programmes, and their implementation and evaluation. The current protocol article describes the development of a TPSR-based instructor training programme and a plan for an intervention study in which novice instructors learn to understand and apply the TPSR model in practice. The …
Organisaation vihreä työkalu : Green Office -ympäristöjärjestelmän vaikutukset organisaatiossa
2010
Ilmastonmuutos herättää keskustelua kansalaisissa ja nykyään myös entistä enemmän organisaatioissa. Kustannuksia syntyy, kun ympäristövaikutuksia ja sitä kautta ilmastonmuutosta pyritään hidastamaan, mutta huomattavasti vähemmän kuin ilmastonmuutoksen seurauksista voi pahimmillaan syntyä, ellei asiaan puututa ajoissa. Ympäristöjärjestelmä on yksi keino ottaa ympäristövastuu kokonaisvaltaisesti organisaatiossa huomioon. Lisäksi sidosryhmien painostus, kiristyvät lait ja asetukset sekä kilpailuedun tavoittelu ohjaavat organisaatioita ympäristöjärjestelmien käyttöönottoon. Niin kutsuttu kevennetty ympäristöjärjestelmä voi olla ISO 14001 -standardia tai EMAS-järjestelmää sopivampi ratkaisu toim…
Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells.
2014
Abstract Background Resistance of cancer cells towards chemotherapeutics represents a major cause of therapy failure. The objective of our study was to evaluate cellular defense strategies in response to the novel vacuolar H+-ATPase inhibitor, archazolid B. Experimental approach: The effects of archazolid B on T24 bladder carcinoma cells were investigated by combining “omics” technologies (transcriptomics (mRNA and miRNA) and proteomics). Free cholesterol distribution was determined by filipin staining using flow cytometry and fluorescence microscopy. Flow cytometry was performed for LDLR surface expression studies. Uptake of LDL cholesterol was visualized by confocal microscopy. SREBP acti…
Fluvastatin stabilizes the blood–brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains
2006
Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme-A reductase and the downstream mevalonate pathway is in part responsible for the beneficial effects that statins exert on the cardiovascular system. In this study we aimed at analysing the stabilizing effects of fluvastatin on the blood-brain barrier (BBB) integrity, using an in vitro co-culture model of ECV304 and C6, or primary bovine endothelial cells and rat astrocytes. Fluvastatin dose-dependently (1-25 micromol/l) increased barrier integrity as analysed by measurements of transendothelial electrical resistance (TEER). This effect (117.4+/-2.6% at 25 micromol/l) was significantly reduced by the nitric oxide (NO) synthase inhibitor L…
Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro.
2008
Abstract Glutamate is an important excitatory amino acid in the central nervous system. Under pathological conditions glutamate levels dramatically increase. Aim of the present study was to examine whether the HMG-CoA inhibitor fluvastatin prevents glutamate-induced blood-brain-barrier (BBB) disruption. Measurements of transendothelial electrical resistance (TEER) were performed to analyze BBB integrity in an in vitro co-culture model of brain endothelial and glial cells. Myosin light chain (MLC) phosphorylation was detected by immunohistochemistry, or using the in-cell western technique. Intracellular Ca 2+ and reactive oxygen species (ROS) levels were analyzed using the fluorescence dyes …
Avoin ongelmista - ongelma avoimuudesta? : arvonluonnin diskurssit integroiduissa raporteissa
2015
Tutkimuksen tavoitteena oli lisätä ymmärrystä integroidusta raportoinnista ja syventää ymmärrystä arvonluonnin käsitteestä. Työn teoreettinen viitekehys rakentui vuosikertomuksiin, yhteiskuntavastuuseen ja integroituun raportointiin liittyvästä tutkimuskirjallisuudesta. Työn aineistona käytettiin seitsemän pohjoismaisen rakennus- ja infrastruktuurialan integroitua raporttia vuosilta 2012–2013. Työn metodologisena otteena käytettiin kolmeen tasoon jaettua kriittistä diskurssianalyysiä, jossa analyysi alkaa tekstuaaliselta tasolta ja siirtyy tulkinnallisen analyysin jälkeen kriittisen analyysin tasolle. Kriittisellä tasolla tarkastellaan arvonluontiin liittyviä valtarakenteita ja niiden ongel…