Search results for "VAST"
showing 10 items of 918 documents
La simvastatina riduce le lipoproteine aterogene in pazienti con coronaropatia prematura: effetti delle statine “beyond-cholesterol”
2002
L'istituzione dei Liberi consorzi di Comuni e delle Città metropolitane in Sicilia, ovvero della specialità vagheggiata
2018
L'istituzione dei liberi Consorzi di Comuni e delle città metropolitane ha impegnato l'Assemblea regionale nella precedente legislatura, senza che sia stata prodotta una disciplina organica, in grado di dare attuazione all'art. 15 dello Statuto tenendo conto anche dei vincoli alla potestà legislativa esclusiva della Regione. Di qui le pronunce della Corte costituzionale. Il saggio esamina la relativa problematica.
Keskustelukumppanin kehuminen suomalaisessa keskustelussa
2013
Artikkelissa tarkastellaan suomalaisen arkikeskustelun kehuja kolmen peruskysymyksen kautta: 1) millaisia kehut ovat rakenteeltaan, 2) miten kehut otetaan vastaan ja 3) millaisissa tilanteissa kehuja esitetaan ja mita niilla tehdaan? Tutkimus on metodiltaan keskustelunanalyyttinen: kehuja analysoidaan osana aitojen keskustelujen toiminnallista kudosta. Kehu maaritellaan tutkimuksessa vastaanottajaan tavalla tai toisella kohdistuvaksi myonteiseksi arvioksi. Kehu voi arvioida vastaanottajaa monella tavalla: kehuttavana voi olla esimerkiksi puhekumppanin luonne, hanen toimintansa tietyssa tilanteessa tai vaatetus, hiukset tai asunto. Aineistona on seka nauhoitetuista arkikeskusteluista poimitt…
The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.
2012
Liver is the main detoxifying organ and therefore the target of high concentrations of genotoxic compounds, such as environmental carcinogens and anticancer drugs. Here, we investigated the usefulness of lovastatin, which is nowadays widely used for lipid lowering purpose, as a hepatoprotective drug following the administration of the anthracycline derivative doxorubicin in vivo. To this end, BALB/c mice were exposed to either a single high dose or three consecutive low doses of doxorubicin. Acute and subacute hepatotoxicities were analyzed with or without lovastatin co-treatment. Lovastatin protected the liver against doxorubicin-induced acute pro-inflammatory and pro-fibrotic stress respo…
Computer Science Outreach Workshop and Interest Development: A Longitudinal Study
2018
This longitudinal study investigates the impact of an extra-curricular programming workshop in student interest development in computer science. The workshop was targeted at 12–18-year old youngsters. A survey was sent to all previous participants with a known home address; 31.5% responded the survey (n = 197). This data was then combined with pre-workshop survey data, and analyzed with mixed methods. Positive development of interest was discovered for 57% of the respondents, of which nearly all attributed their interest increase to the workshop at least partly (92%). Qualitative inspection revealed that the workshop provided three anchors that facilitated students’ reengagement with progra…
Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases
2018
Abstract There is insufficient evidence to support screening of various tick-borne diseases (TBD) related microbes alongside Borrelia in patients suffering from TBD. To evaluate the involvement of multiple microbial immune responses in patients experiencing TBD we utilized enzyme-linked immunosorbent assay. Four hundred and thirty-two human serum samples organized into seven categories followed Centers for Disease Control and Prevention two-tier Lyme disease (LD) diagnosis guidelines and Infectious Disease Society of America guidelines for post-treatment Lyme disease syndrome. All patient categories were tested for their immunoglobulin M (IgM) and G (IgG) responses against 20 microbes assoc…
Mikrokokoistetut leviämisvastus- ja nelipisteanturimittaukset puolijohderakenteen varauksenkuljettajien syvyysjakaumien määrittämisessä
2013
Entistä pienemmät puolijohderakenteet vaativat analyysityökaluilta erittäin hyvää herkkyyttä, jonka on myös kehityttävä rakenteiden vaatimusten mukaisesti -- muussa tapauksessa kehitys voi hidastua hyvin paljon ilman kunnollista tietoa valmistusmenetelmien tuloksista. Yksi oleellinen osa rakenteiden analysoimisessa on tieto seostusatomien ja varauksenkuljettajien pitoisuuksista rakenteen syvyyssuunnassa, eli syvyysjakauma. Vuosikymmeniä syvyysjakauman mittaukseen on käytetty leviämisvastusmittausta (SRP, engl. Spreading Resistance Profiling), ja nelipisteanturimittausta (4PP, engl. Four Point Probe) on käytetty kuvaamaan koko syvyysjakauman vaikutusta sähköisessä kontaktissa. Molempien tekn…
Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells
2011
Lovastatin (Lov), bisphosphonates (BP) and metformin (Met) are widely used drugs, having in common that they interfere with the mevalonate pathway (MP). The MP generates isoprene moieties required for the function of regulatory GTPases controlling cell proliferation and survival. Here, we addressed the question whether MP inhibitors interfere with the anti-tumor efficacy of anticancer drugs. We comparatively analyzed the effect of equitoxic doses of Lov, BP and Met on cell viability, cell cycle progression, apoptosis and DNA damage response (DDR) of human osteo- and fibrosarcoma cells exposed to doxorubicin or cisplatin. We found that Lov, BP and Met modulated the anticancer drug sensitivit…
Molecular signaling in muscle is affected by the specificity of resistance exercise protocol
2010
Mammalian target of rapamycin and mitogen-activated protein kinase (MAPK) signaling pathways have been highlighted as important for muscle adaptations and thus, they may distinguish adaptations to different exercises. Typically, resistance exercise designed for muscle hypertrophy has moderate intensity (60-80% of one repetition maximum, 1 RM) while one prioritizing maximal strength with minor hypertrophy has a higher intensity (≥90% of 1 RM). Eight untrained men (28.4 ± 3.7 years) conducted two different bilateral leg press exercise protocols: hypertrophic (5 × 10 RM) and pure maximal strength (15 × 1 RM) in a counterbalanced, cross-over design with 1 week between exercises. Vastus laterali…