Search results for "VAST"
showing 10 items of 918 documents
Alcune considerazioni e prospettive sul ruolo della pianificazione territoriale per la valuitazione strutturale e strategica in un processo partecipa…
2005
All'interno della procedura per la formazione del Piani territoriali di coordinamento provinciale viene proposta una metodologia per la valutazione e programmazione strutturale e strategica dei servizi d'area vasta in una visione policentrica all'interno di parchi. La procedura di valutazione della domanda e dell'offerta e quindi degli scenari di programmazione territoriale vengono strutturati in una copianificazione multilivello che coinvolge secondo i principi di sussidiarietà la programmazione regionale e le scelte localizzative a livello locale all'interno di ambiti intercomunali di ottimizzazione.
A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates
2020
A proof-of-concept study shows the generation of an immunogenic hexavalent Coxsackie B virus vaccine that prevents disease.
Genetic diagnosis of familial hypercholesterolemia in a South European outbreed population: influence of low-density lipoprotein (LDL) receptor gene …
2001
The aims of this study were to examine the presence of mutations in the low-density lipoprotein receptor gene among subjects clinically diagnosed with familial hypercholesterolemia and to analyze whether the molecular diagnosis helps to predict the response to simvastatin treatment in our familial hypercholesterolemia population. Fifty-five probands and 128 related subjects with familial hypercholesterolemia were studied. Genetic diagnosis was carried out following a three-step protocol based on Southern blot and PCR-single strand conformational polymorphism analysis. A randomized clinical trial with simvastatin was conducted in 42 genetically diagnosed subjects with familial hypercholester…
The role of negative and positive forms of power in supporting CSR alignment and commitment between large firms and SMEs
2018
Do large firms exert power to shape the CSR behavior of their SME partners?” We answer this question by proposing a model built on the stakeholder theory and the shareholder theory, and go on to explain how this impact influences the commitment of the SME towards their large partner. The model highlights the central role that different forms of power exercised by the large firm play in the process. A survey of 291 SMEs confirms the key hypotheses, including the mediating role of reward power. The effects of coercive power are noteworthy and they illustrate the complex and competing forces at play in influencing CSR behavioral change in SMEs. The research makes a novel contribution to practi…
Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo.
2009
Abstract Background and purpose HMG-CoA-reductase inhibitors (statins) are widely used lipid-lowering drugs. Moreover, they have pleiotropic effects on cellular stress responses, proliferation and apoptosis in vitro . Here, we investigated whether lovastatin attenuates acute and subchronic ionizing radiation-induced normal tissue toxicity in vivo . Materials and methods Four hours to 24h after total body irradiation (6Gy) of Balb/c mice, acute pro-inflammatory and pro-fibrotic responses were analyzed. To comprise subchronic radiation toxicity, mice were irradiated twice with 2.5Gy and analyses were performed 3weeks after the first radiation treatment. Molecular markers of inflammation and f…
The Pain of Granting Otherness : Interoception and the Differentiation of the Other / Der Schmerz der Gewährung von Andersheit : Interozeption und di…
2017
SummaryThis article examines the foundations of social experience from a psychoanalytic perspective. In current developmental psychology, social cognition debate, and phenomenology of empathy, it is widely assumed that the self and the other are differentiated from the outset, and the basic challenge is accordingly taken to consist in explaining how the gap between the self and the other can be bridged. By contrast, in the psychoanalytic tradition, the central task is considered to lie in explaining how such a gap is established in the first place. My article develops this latter idea. I focus on the infant’s early experience of care, show how the presence of the caregiver can be interprete…
The illusion of contact: Insights from Winnicott’s 1952 letter to Klein
2021
Using Winnicott’s theory, this article produces an account of the individual’s relation to a given conceptual framework. Whereas Winnicott’s ideas have been almost exclusively discussed in developmental and psychopathological contexts, the present article extends Winnicott’s theory and applies it to the problem of interpersonal understanding. Taking a lead from one of Winnicott’s letters to Klein, the article investigates the problem of expressing one’s idiosyncratic insights in the confines of a given conceptual framework. The article examines Winnicott’s theory of compliance and creativity, discusses the plea that Winnicott makes to Klein, analyses the encounter with a “dead language”, an…
Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiat…
2014
Cigarette smoking contributes to epithelial-mesenchymal transition (EMT) in COPD small bronchi as part of the lung remodeling process. We recently observed that roflumilast N-oxide (RNO), the active metabolite of the PDE4 inhibitor roflumilast, prevents cigarette smoke-induced EMT in differentiated human bronchial epithelial cells. Further, statins were shown to protect renal and alveolar epithelial cells from EMT. To analyze how RNO and simvastatin (SIM) interact on CSE-induced EMT in well-differentiated human bronchial epithelial cells (WD-HBEC) from small bronchi in vitro. Methods: WD-HBEC were stimulated with CSE (2.5%). The mesenchymal markers vimentin, collagen type I and α-SMA, the e…
Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium
2016
AIMS: Our aims were to evaluate the distribution of troponin I concentrations in population cohorts across Europe, to characterize the association with cardiovascular outcomes, to determine the predictive value beyond the variables used in the ESC SCORE, to test a potentially clinically relevant cut-off value, and to evaluate the improved eligibility for statin therapy based on elevated troponin I concentrations retrospectively.METHODS AND RESULTS: Based on the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, we analysed individual level data from 10 prospective population-based studies including 74 738 participants. We investigated the value of adding troponin …
"Kumpi on vaarallisempaa, porno vai romanttinen viihde?": Fifty Shades Of Grey -trilogian vastaanotto ja sen vaikutukset nykykulttuurissa
2016
Opinnäytetyö tutkii Fifty Shades of Grey -trilogiaa reseptiotutkimuksen kautta. Tutkielma analysoi pääasiassa internetissä julkaistuja lukijoiden tekstejä ja muita vastaanottoa käsitteleviä tekstejä. Tutkielma pyrkii myös selvittämään millainen vaikutus trilogialla on nykykulttuuriin ja sen erotisoitumiseen.