Search results for "VAST"
showing 10 items of 918 documents
UML Artefacts for a Blockchain-enabled Platform for Fairtrade
2021
Fairtrade-certified products have successfully entered the mainstream distribution channels mostly in developed countries, and these products are now sold in famous supermarket chains. Nonetheless, the packaging and labeling of products as “Fairtrade” commands premium pricing in the marketplace. How much of this, however, is valid and justified? Despite the reputable certification mechanisms for quality assurance, mass media reports suggest that much of the “surplus value” goes to the accreditation agencies themselves instead of the producers. This article proposes an agenda to set this right with a blockchain platform that provides “trust-free” assurances of verifiable labeling. Using an A…
Concurrent endurance and strength training : neuromuscular, cardiorespiratory and hormonal effects of the exercise order in previously untrained and …
2015
The aim of the present thesis was two-fold. First, to investigate physiological adaptations to concurrent endurance and strength training performed in the same session with different exercise orders (i.e. commencing training with endurance or strength, respectively; E+S vs. S+E) in previously untrained men (n=42) (study 1). Second, to examine physiological adaptations when strength training was always performed immediately after endurance running in the same session (E+S) compared to endurance training alone (E) in recreational endurance runners (n=30) (study 2). In study 1, training consisted of 2 - 3 weekly combined endurance cycling and mixed hypertrophic and maximal strength training se…
Muscle-Tendon Interaction During Human Dolphin-Kick Swimming
2019
Without high impact forces, it is not clear how humans can utilize tendon elasticity during low-impact activities. The purpose of the present study was to examine the muscle-tendon behavior together with the electromyographic (EMG) activities of the vastus lateralis (VL) muscle during the human dolphin-kicking. In a swimming pool, each subject (n = 11) swam the 25 m dolphin-kicking at two different speeds (NORMAL and FAST). Surface EMGs were recorded from the VL and biceps femoris (BF) muscles. Simultaneous recordings of the knee joint angle by electro-goniometer and of the VL fascicle length by ultrasonography were used to calculate the muscle-tendon unit and tendinous length of VL(L-MTU a…
Kuluttajaboikotit ja cancel-kulttuuri
2022
Organisaatiot, brändit ja yhteisöt ovat viime aikoina törmänneet yhä nopeampaan ja monikanavaisempaan kuluttajaboikotointiin ja sen aiheuttamiin viestinnällisiin haasteisiin. Tässä niin kutsutussa kansanomaisessa käänteessä, joka sosiaalisen median myötä on tuonut keskiöön tavallisten ihmisten vaikutusvallan ohi instituutioiden, piilee organisaatioilla aikaisempaa suurempi riski joutua boikotin kohteeksi. Boikotoinnin eri muodot: ostoboikotti, perinteinen boikotti ja epäsuora boikotti ovat kaikki vaikuttavia toimintatapoja tuotteiden ja palveluiden kysynnälle. Boikotoinnin uusina ilmentyminä ovat viime aikoina yleistyneet cancel- ja woke-aloitteet, jotka voidaan nähdä yksilöiden uudenlaisen…
Hashtagin kaappaaminen Twitterissä : huumoria, kritiikkiä ja huutelua
2016
Sosiaalinen media tuo organisaatiot ja yleisöt yhteiselle areenalle, jossa organisaatioiden on keksittävä uusia tapoja saadakseen yleisöjen huomion sekä pitääkseen viestinsä pinnalla ja jossa yleisöillä on mahdollisuus kyseenalaistaa organisaatioita. Tämän tutkimuksen tavoitteena oli selvittää tilannetta, jossa yleisö kaappaa organisaation Twitter- kampanjan hashtagin ja kääntää kampanjan organisaatiota vastaan. Tutkimuksessa selvitetään, millainen prosessi hashtagin kaappaaminen on ja millaisia kaappauksia hashtagilla on tutkimalla kahvilaketju Starbucksin maaliskuussa 2015 lanseeraaman racetogether-kampanjan hashtagia. Tutkimusaineistoksi kerättiin tuhat #racetogether-hashtagilla merkitty…
Measurement of haemodynamics of exercising and non-exercising vastus lateralis muscle with hybrid diffuse optics
2016
We present simultaneous diffuse correlation spectroscopy (DCS) and time resolved spectroscopy (TR NIRS) measurements on exercising and non-exercising vastus lateralis muscle. We discuss the results at two different exercise levels.
Ezetimibe, cardiovascular risk and atherogenic dyslipidaemia.
2010
Ezetimibe is a selective cholesterol absorption inhibitor with an excellent side-effect profile, able to reduce low-density lipoprotein (LDL) cholesterol by 15-25% from baseline in monotherapy and on top of statins and fibrates. Yet, it seems that ezetimibe produces quantitative rather than qualitative changes in LDL, with small net effects on atherogenic dyslipidaemia. This is supported by findings from the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study on atherosclerosis progression, where the addition of ezetimibe to simvastatin in patients with heterozygous familial hypercholesterolaemia did not affect the mean change in carotid int…
Effects of statins, fibrates, rosuvastatin, and ezetimibe beyond cholesterol: the modulation of LDL size and subclasses in high-risk patients.
2007
Increasing evidence suggests that the quality-rather than just the quantity-of low-density lipoproteins (LDLs) exerts a great influence on cardiovascular risk. LDLs comprise multiple subclasses with discrete size and density, and different physicochemical composition, metabolic behaviors, and atherogenicity. Individuals generally cluster into 2 broad subgroups. Most have a predominance of large LDLs, and some have a higher proportion of small particles. Small, dense LDLs are good predictors of cardiovascular events and progression of coronary artery disease. Their predominance has been accepted as an emerging cardiovascular risk factor by the National Cholesterol Education Program Adult Tre…
Design, synthesis, biological evaluation and molecular modelling of substituted pyrrolo[2,1-a]isoquinolinone derivatives: discovery of potent inhibit…
2021
We report here the design, synthesis and biological evaluation of a new series of substituted pyrrolo[2,1-a]isoquinolin-3-one derivatives, some of which have strong inhibitory activity against both AChE and BChE enzymes. The design of these new inhibitors was carried out taking rivastigmine as the starting structure. Thus, on the basis of an exhausting molecular modeling study using combined techniques (docking, dynamic molecular simulations and QTAIM calculations), we obtained new ligands possessing stronger inhibitory effects than rivastigmine, the reference compound. QTAIM analysis gave us detailed information about the molecular interactions stabilizing the different ligand–enzyme compl…
The Effects of Resistance Training on Physical Fitness and Neuromotor-Cognitive Functions in Adults With Down Syndrome
2022
Adults with Down syndrome are an underserved population at high risk for a host of different pathologies from aging and lack of activity.PurposeTo examine the effects of a 10-week resistance training program on measures of motor behavior, cognitive function, mood, and physical fitness.MethodsParticipants (n = 11) were men and women clinically diagnosed with Down syndrome (age: 25.8 ± 6.4 years; height: 151.5 ± 8.3 cm; weight: 67.5 ± 13.0 kg; IQ: 58.3 ± 19.7 units). After familiarization of testing procedures, subjects performed The Arizona Cognitive Test Battery for Down Syndrome, TGMD-2, lower and upper body strength assessments, and body composition via DXA testing, while parental guardia…