Search results for "VDAC2"

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Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy

2019

The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and additionally, recent evidence shows that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary-open angle glaucoma patients (POAG) compared to healthy controls. Synthetically antibody-derived peptides can modulate various effector functions of the immune system and act as antimicrobial or antiviral molecules. In an ex vivo adolescent glaucoma model, this study, for the first time, demonstrates that polyclonal-derived complementarity-determining regions (CDRs) can significantly increase the survival rate …

<i>Sus scrofa domestica</i>lcsh:MedicineRetinal ganglionEpitopeArticleSus scrofa domestica03 medical and health scienceschemistry.chemical_compound0302 clinical medicineImmune systemMedicine030304 developmental biology0303 health sciencesHTRA2synthetic CDR peptidesbusiness.industrylcsh:RautoimmunityRetinalGeneral MedicineProtein ubiquitinationCell biologyglaucomachemistryneuroprotectionSignal transductionbusinessVDAC2030217 neurology & neurosurgeryEx vivoJournal of Clinical Medicine

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PEPhysical Sciences and Engineering
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LSLife Sciences
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SHSocial Sciences and Humanities
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