Search results for "VEGFR2"
showing 3 items of 3 documents
Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation
2018
Autophagy and exosome secretion play important roles in a variety of physiological and disease states, including the development of age‐related macular degeneration. Previous studies have demonstrated that these cellular mechanisms share common pathways of activation. Low oxidative damage in ARPE‐19 cells, alters both autophagy and exosome biogenesis. Moreover, oxidative stress modifies the protein and genetic cargo of exosomes, possibly affecting the fate of surrounding cells. In order to understand the connection between these two mechanisms and their impact on angiogenesis, stressed ARPE‐19 cells were treated with a siRNA‐targeting Atg7, a key protein for the formation of autophagosomes.…
Ramucirumab in elderly patients with hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib in REACH and REACH-2.
2020
Background & Aims: Limited data on treatment of elderly patients with hepatocellular carcinoma (HCC) increase the unmet need. REACH and REACH-2 were global phase III studies of ramucirumab in patients with HCC after prior sorafenib, where patients with alpha-fetoprotein (AFP) ≥400 ng/mL showed an overall ssurvival (OS) benefit for ramucirumab. These post-hoc analyses examined efficacy and safety of ramucirumab in patients with HCC and baseline AFP ≥ 400 ng/mL by three prespecified age subgroups (<65, ≥65 to <75 and ≥75 years). Methods: Individual patient data were pooled from REACH (baseline AFP ≥400 ng/mL) and REACH-2. Kaplan-Meier and Cox proportional hazards regression methods …
Análisis inmunohistoquímico de mediadores moleculares implicados en angiogénesis LDH5 y VEGFR2/pKDR en pacientes con cáncer colorrectal avanzado: det…
2017
Tema. El esquema de tratamiento de primera línea estándar más utlizado para los pacientes diagnosticados de adenocarcinoma colorectal avanzado es en la actualidad la combinación de Oxaliplatino, Fluoropirimidinas y Bevacizumab. No todos los pacientes se benefician de igual manera, siendo necesarios identificar marcadores moleculares capaces de predecir el pronóstico y la posibilidad de respuesta. Objetivos. El objetivo de nuestro estudio es determinar el papel pronóstico y predictivo de la expresión inmunohistoquímica de dos proteínas implicadas en la angiogénesis y adaptación metabólica a la hipoxia tumoral: LDH5 y VEGFR/pKDR, en pacientes tratados con Oxaliplatino y Fluoropirimidinas con …