Search results for "VID"
showing 10 items of 14131 documents
Experimental evolution of genome architecture and complexity in an RNA virus
2016
Introducción La evolución de la arquitectura del genoma – las dimensiones y la organización del material hereditario de un organismo – es poco conocida. Existe una variación asombrosa en la arquitectura genómica entre diferentes organismos. Los virus tienden a tener genomas pequeños, con un mínimo de secuencias intergénicas y típicamente con genes solapantes, los cuales se cree son una forma de compresión del genoma que permite al virus incrementar su número de proteínas sin aumentar su tamaño. Los procariotas tienen genomas compactos, pero con secuencias intergénicas más largas que los virus, y los genes con solapamientos largos son escasos. Los eucariotas presentan una amplia gama de tama…
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
2021
The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-domina…
Internalization of novel non-viral vector TAT-streptavidin into human cells
2007
BMC Biotechnology, 7 (1)
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
Viruscat
2021
VIRUSCAT: CATÀLEG DE VIRUS ASSOCIATS A MALALTIES EN HUMANS VIRUSCAT: CATALOG OF VIRUSES ASSOCIATED WITH HUMAN DISEASES
STAT1 and Its Crucial Role in the Control of Viral Infections
2022
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs. STAT1 activates the transcription of hundreds of genes, some of which have been well characterized for their antiviral properties. STAT1 gene deletion in mice and complete STAT1 deficiency in humans both cause rapid death from severe infections. STAT1 plays a key role in the immunoglobulin class-switch recombination through the upregulation of T-bet; it also plays a key role in the production of T-bet+ memory B cells that contribute to tissue-resident humoral memory…
SARS-CoV-2 envelope protein topology in eukaryotic membranes
2020
Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Nt lum /Ct cyt ). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and ho…
Caracterización del viroma en plasma de donantes de sangre
2022
El desarrollo de la metagenómica ha impulsado el descubrimiento de un número notable de nuevas secuencias virales, lo que ha permitido conocer la composición de las comunidades virales de múltiples ambientes, entre los que se incluye el cuerpo humano. El viroma humano se caracteriza por presentar una enorme heterogeneidad, en cada localización corporal existe un ambiente determinado, lo que se refleja en una composición muy diversa de las comunidades de virus y bacterias presentes. En concreto, el plasma sanguíneo se caracteriza por albergar diferentes virus, incluso en individuos aparentemente sanos, como los donantes de sangre. Para caracterizar los virus presentes en muestras de plasma, …
Uzņēmējspēju attīstīšanas ieviešana "Uz zināšanām balstītas ekonomikas" kontekstā vispārējās vidējās izglītības mācību priekšmetā "Ekonomika"
2015
Bakalaura darbs Uzņēmējspēju attīstīšanas ieviešana „uz zināšanām balstītas ekonomikas” kontekstā vispārējās vidējās izglītības mācību priekšmetā „Ekonomika” izstrādāts, lai izvirzītu priekšlikumus ekonomikas izglītības īstenošanai vispārējās vidējās izglītības līmenī Latvijā. Mūsdienu ekonomikas centrā ir izglītots cilvēkkapitāls. Pamata zināšanas ekonomikā ir nepieciešamas ikvienam sabiedrības loceklim, lai tas varētu kļūt par „gudru” darba ņēmēju, darba devēju un „gudru” patērētāju. Autore veica „uz zināšanām balstītas ekonomikas” teorētisko aspektu analīzi, šī brīža ekonomikas izglītības analīzi Eiropā kopumā un Norvēģijā un Latvijā atsevišķi. Pētījumā secināta nepieciešamība ieviest La…