Search results for "VIRUS DISEASE"
showing 10 items of 1907 documents
SARS-CoV-2 Infection in Healthcare Professionals and General Population During “First Wave” of COVID-19 Pandemic: A Cross-Sectional Study Conducted i…
2021
On December 31, 2019, an outbreak of lower respiratory infections was documented in Wuhan caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the beginning, SARS-CoV-2 has caused many infections among healthcare workers (HCWs) worldwide. Aims of this study were: a. to compare the distribution among the HCWs and the general population of SARS-CoV-2 infections in Western Sicily and Italy; b. to describe the characteristics of HCWs infected with SARS-CoV-2 in the western Sicilian healthcare context during the first wave of the epidemic diffusion in Italy. Incidence and mean age of HCWs infected with SARS-CoV-2 were comparable in Western Sicily and in the whole Ita…
Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score
2021
The British journal of surgery 108(11), 1274-1292 (2021). doi:10.1093/bjs/znab183
Physical activity using social media during the COVID-19 pandemic: the perceptions of sports science students
2021
Abstract During the period of the COVID-19 lockdown, sports organizations and companies had to look for new ways to connect with their customers by offering physical activity (PA) alternatives to do at home. This study explores the perceptions of 175 undergraduate sports science students regarding their social media (SM) and PA patterns during the first Spanish COVID-19 lockdown period (March to May 2020). From their homes, the students completed an ad hoc online questionnaire. The data was analyzed using SPSS 23.0 software to perform descriptive and inferential analysis (t-test). The results show that the participants used SM during the COVID-19 lockdown to visualize or practice PA, percei…
New Older Users’ Attitudes Toward Social Networking Sites and Loneliness: The Case of the Oldest-Old Residents in a Small Italian City
2021
Older adults make little use of social networking sites (SNS). SNS has become essential for maintaining social contacts and countering loneliness in the current era marked by the Covid-19 pandemic. This study explores the attitudes of the oldest-old on SNS after attending a training course on SNS use. The study’s goals are to investigate their personal experiences, choices of use and to survey their views on the usefulness of SNS and its effects on mitigating loneliness for older people. The interviews were conducted in the context of the “Ageing in a Networked Society—Social Experiment Study.” The participants, who were randomly selected for the course on SNS use, agreed to be interviewed…
It’s Beyond Our Group ZPD
2021
This study is a replication of Upper (1974). Our results are identical. We too have been unable to focus and accomplish our writing goals since the beginning of the global pandemic. We are certainly not alone, and we would like to recognize all of our colleagues who have also had to take on additional responsibilities at work and at home over the past year that have made writing nearly impossible.
Lessons from Remote School and Work
2021
In autumn 2021, Covid-19 still has effect on our daily living and our possibilities to conduct everyday life practices such as work and studies. Current realities of ‘new normality’, based on remote work and restrictions of social activities, for example, are grounded on the vast changes that occurred when the pandemic began. In this text we take a look back to the period of school closures in Finland, and their effect on families’ daily practices related to children’s well-being and school work. We explore the impacts of remote school to learning opportunities to find ways to utilize the new, good practices of remote school also in the future. At the same time, we emphasize the significanc…
Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with…
2017
Summary Background We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decompensation while approval of these regimens was pending in Italy. Methods In this prospective observational study, we collected data from a compassionate use nationwide programme from March 17, 2014, to May 28, 2015. Patients with HCV genotype 1 infection and cirrhosis at high risk of decompensation were given coformulated ombitasvir (25 mg), …
Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults
2015
Objective: The prevalence of overweight and obesity is increasing among HIV-infected patients. Whether standard antiretroviral drug dosage is adequate in heavy individuals remains unresolved. We assessed the virological and immunological responses to initial efavirenz (EFV)-containing regimens in heavy compared to normal-weight HIV-infected patients. Design: Observational European cohort collaboration study. Methods: Eligible patients were antiretroviral-naive with documented weight prior to EFV start and follow-up viral loads after treatment initiation. Cox regression analyses evaluated the association between weight and time to first undetectable viral load ( 50 copies/ml) after initial s…
Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95
2013
The potential cardiovascular (CV) toxicity associated with combined antiretroviral therapy (cART) has been attributed mainly to the nucleoside reverse transcriptase inhibitors abacavir and didanosine. However, the other two components of cART--non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs)--may also be implicated, either directly or by influencing the action of the other drugs. This study evaluates the acute direct effects of the NNRTIs efavirenz and nevirapine and one of the most widely employed PIs, lopinavir, on leucocyte-endothelium interactions, a hallmark of CV disease.Drugs were analysed in vitro in human cells (interactions of peripheral blood…
Pharmacokinetic interaction between efavirenz and ketoconazole in rats
2009
It is well known that efavirenz and ketoconazole act as an inducer and inhibitor of CYP3A4, respectively. As a result of these actions, co-administration of these drugs may result in changes in the pharmacoki- netic parameters of one or both of them. 2. Duodenum-cannulated rats have been used to compare the effect of intraduodenal (KC i.d. ) and intrave- nous administration of ketoconazole (KC i.v. ) on the pharmacokinetics of efavirenz after intraduodenal administration, as well as the potential effect of efavirenz as a CYP450 inducer on ketoconazole phar - macokinetic profile. 3. While KC i.v. did not show any significant effect on efavirenz pharmacokinetic profile, KC i.d. increased sig-…