Search results for "VIRUS DISEASE"
showing 10 items of 1907 documents
Island Geographies of Separation and Cohesion: The Coronavirus (COVID-19) Pandemic and the Geopolitics of Kalaallit Nunaat (Greenland).
2020
Abstract Kalaallit Nunaat (Greenland) is an Arctic highly autonomous subnational island jurisdiction (SNIJ) of Denmark, its former coloniser. The coronavirus (COVID‐19) pandemic of 2020 has influenced both Kalaallit Nunaat’s relations with the outside world and relations between people and places within the territory. The Kalaallit Nunaat government’s response to the pandemic, including both internal and external travel bans and restrictions on movement, has focused on eradicating the disease from the territory. This strategy, however, is challenged both by the SNIJ’s economic reliance on Denmark and by the Danish government’s own strategy of mitigating the disease. This paper explores the …
All that glitters is not gold. The rise of gaming in the COVID-19 pandemic
2020
Abstract The COVID-19 pandemic has led to an unprecedented situation, with incalculable health, social, and economic consequences. At the start of the outbreak, the financial markets collapsed, although not all sectors suffered equally. The gaming and eSports industry is one of those that has suffered the least from the fall in the markets. Millions of people locked up at home, bored, stressed, and anguished, gave gaming and eSports companies growing prominence throughout the first half of 2020. This prominence has elicited interest in analyzing which variables can influence the returns in an industry in better financial health than many others. Using a logit–probit model, this research aim…
Política monetaria en tiempos de pandemia: evaluación y propuesta del Helicóptero Monetario
2020
La pandemia del Covid-19 ha provocado una de las crisis más importantes desde la Gran Depresión. Ante esto, es necesaria una mayor coordinación entre la política monetaria y las políticas fiscales. En este artículo, se ha analizado el Helicóptero Monetario como posible respuesta a la crisis y como complemento a las medidas adoptadas. Tras presentar evidencia histórica de los efectos del Helicóptero Monetario, examinar los distintos ejemplos propuestos en la literatura, y evaluar sus fortalezas y debilidades, se ha articulado una propuesta para la eurozona a través del Banco Central Europeo (BCE) en coordinación con el grupo del Banco Europeo de Inversiones (BEI)
The impact of social capital and collaborative knowledge creation on e-business proactiveness and organizational agility in responding to the COVID-1…
2020
The purpose of this study is to explore the role of social capital and collaborative knowledge creation in achieving e-business proactiveness in responding to the COVID-19 crisis An online survey was used to collect data from industries that had to continue working during the crisis, such as the pharmaceutical and cleaning materials sectors The sample consisted of 198 managers The findings show that social capital and collaborative knowledge creation have a significant role in achieving e-business proactiveness in responding to the pandemic The results also show the positive impact of collaborative knowledge creation and e-business proactiveness on organizational agility during the crisis T…
Teaching in times of COVID-19: determinants of teachers' educational technology use
2021
We conduct a large and nationwide survey among German teachers to investigate the determinants of teachers' adaption to an increased use of educational technology during the COVID-19 school closure...
Determinants of COVID-19 Vaccine Rollouts and Their Effects on Health Outcomes
2022
Background Vaccination against the coronavirus disease (SARS-CoV-2) is understood to be the key way out of the COVID-19 pandemic. Limited evidence exists on the determinants of vaccine rollouts and their health effects at the country level. Objective Examine the determinants of COVID-19 vaccine rollouts and their effects on health outcomes. Methods Ordinary least squares regressions with standard errors clustered at the country level for Cross-section and Panel daily data of vaccinations and various health outcomes (new COVID-19 cases, fatalities, intensive care unit (ICU) admissions) for an unbalanced sample of about 200 countries during the period 16 December 2020 to 20 June 2021. Results…
Twenty Years of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Time to Reevaluate their Toxicity
2011
Twenty years of effective clinical application have consolidated non-nucleoside reverse transcriptase inhibitors (NNRTI) as essential components of the Highly Active Antiretroviral Therapy (HAART) employed in the treatment of Human Immunodeficiency Virus (HIV). However, as the disease has come under control, there has been growing emphasis on the long-term adverse effects induced by this chronic pharmacological therapy. Although traditionally considered to be safe and well-tolerated drugs, there is mounting evidence that associates NNRTI with the onset of cutaneous reactions, neuropsychiatric symptoms, hepatotoxicity, metabolic disturbances and gastrointestinal toxicity. Though the clinical…
Future Perspectives in NNRTI-Based Therapy: Bases for Understanding Their Toxicity
2011
Continuous administration of the drugs included under the term Highly Active Antiretroviral Therapy (HAART) has turned AIDS into a chronic disease, at least in developed countries (Panos et al., 2008). The initial development of these drugs was particularly rapid and focused on clinical efficacy before all other considerations. However, as the disease has come under control, there has been growing emphasis on the long-term adverse effects associated with this therapy. The first drug for the treatment of HIV infection, zidovudine (AZT), was approved in 1987. The number of other antiretroviral drugs already approved for use or under development continues to grow, and the primary aim of resear…
Differences in Perceived Occupational Stress by Demographic Characteristics, of European Emergency Medical Services Personnel during the COVID-19 Vir…
2021
Objectives: The outbreak of the COVID-19 pandemic has brought commercial, social, and economic consequences in every country that has experienced substantial SARS-CoV-2 infection rates. The complete change in the environment that took place due to the outbreak of the pandemic can lead to stressful situations, especially among healthcare personnel. Material and methods: The research were conducted during the COVID-19 pandemic between the 27 March 2020 and the 20 April 2020. The research included 1984 employees of emergency medical systems in seven European countries. An internet-based questionnaire format was adopted for the study (ΩMc-Donald >
Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents indu…
1993
The phosphodiesterase inhibitor pentoxifylline (POX), which is known to have pharmacological effects in animal models of multiorgan failure and endotoxin-mediated shock, was tested for its immunosuppressive potential on T lymphocyte activation in vitro and in vivo. POX was found to have a profound inhibitory effect on both mitogen- and antigen-induced proliferation of CD4+ T cells in vitro. This inhibitory activity of the drug could be reproduced by treating T lymphocytes with cAMP analogues during stimulation. Responses of repeatedly in vitro stimulated cells were much more strongly inhibited by the drug and by cAMP analogues than responses of fresh resting lymphocytes. Furthermore, POX co…