Search results for "VKA"

The Novel Oral Anticoagulants for Acute Venous Thromboembolism: Is Warfarin Dead?

2017

The direct oral anticoagulants (DOACs) have been compared with parenteral anticoagulants and vitamin K antagonists (VKAs) for the treatment of venous thromboembolism (VTE) in several robust studies. DOACs have shown similar efficacy in preventing recurrent VTE and significant reductions in critical site (intracranial) bleeding, fatal bleeding, major and nonmajor bleeding. Warfarin and other VKAs are not dead as treatment modalities for VTE. A better way to describe the current situation is to use a boxing expression, “down but not out.” VKAs and parenteral anticoagulants still have a role to play in the management of VTE in several clinical settings. In indications where DOACs can be used, …

Cancer patients requiring interruption of long-term warfarin because of surgery or chemotherapy induced thrombocytopenia: The use of fixed sub-therap…

2012

No data are available regarding the management of cancer patients requiring interruption of long-term vitamin-K antagonist (VKA) therapy. For this purpose, we tested the efficacy and safety of fixed doses of low-molecular weight heparin (LMWH) in substitution of VKA because of invasive procedures or chemotherapy-induced thrombocytopenia. In cancer patients on VKA, therapy was discontinued 5 ± 1 days before surgery or chemotherapy. Heparin was given at prophylactic dosage in patients at low risk and at fixed subtherapeutic doses (3,800 or 4,000 UI anti-FXa, b.i.d.) in those at high-risk for thrombosis. LMWH was reinitiated 12 hr after surgery and VKA the day after. In patients receiving chem…

Residual vein thrombosis for assessing duration of anticoagulation after unprovoked deep vein thrombosis of the lower limbs: the extended DACUS study.

2011

Abstract The safest duration of anticoagulation after idiopathic deep vein thrombosis (DVT) is unknown. We conducted a prospective study to assess the optimal duration of vitamin K antagonist (VKA) therapy considering the risk of recurrence of thrombosis according to residual vein thrombosis (RVT). Patients with a first unprovoked DVT were evaluated for the presence of RVT after 3 months of VKA administration; those without RVT suspended VKA, while those with RVT continued oral anticoagulation for up to 2 years. Recurrent thrombosis and/or bleeding events were recorded during treatment (RVT group) and 1 year after VKA withdrawal (both groups). Among 409 patients evaluated for unprovoked DVT…

Antithrombotic Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or with Percutaneous Coronary Intervention …

2019

Background: The safety and efficacy of antithrombotic regimens may differ between patients with atrial fibrillation who have acute coronary syndromes (ACS), treated medically or with percutaneous coronary intervention (PCI), and those undergoing elective PCI. Methods: Using a 2×2 factorial design, we compared apixaban with vitamin K antagonists and aspirin with placebo in patients with atrial fibrillation who had ACS or were undergoing PCI and were receiving a P2Y 12 inhibitor. We explored bleeding, death and hospitalization, as well as death and ischemic events, by antithrombotic strategy in 3 prespecified subgroups: patients with ACS treated medically, patients with ACS treated with PCI,…

Real-World Data of Anticoagulant Treatment in Non-valvular Atrial Fibrillation

2022

AimsTo assess the impact of anticoagulant treatment on risk for stroke and all-cause mortality of patients with atrial fibrillation using real-world data (RWD).MethodsPatients with prevalent or incident atrial fibrillation were selected throughout a study period of 5 years. Stroke, transitory ischemic attack, hemorrhagic stroke, and all-cause mortality were identified in the claims of the electronic health records (EHRs). Subjects were classified according to the anticoagulant treatment in four groups: untreated, vitamin K antagonists (VKAs), New Oral Anticoagulants (NOACs), and antiplatelet (AP). Risk of events and protection with anticoagulant therapy were calculated by Cox proportional h…

Lūgšanu krelles kristietības tradīcijā

2019

Darbs ir par lūgšanu krellēm kristietības tradīcijā un lūgšanu kreļļu materiālo un garīgo aspektu. Pētījuma mērķis ir izprast to nozīmi lūgšanu praksē dažādās kristīgajās konfesijās. Tika apskatītas lūgšanas, lūgšanu kreļļu lietošanas attīstība un savstarpēja mijiedarbība, kā arī tautas dievbijība un baznīcas mācības mijiedarbība. Uzmanība pievērsta baznīctēvu izstrādātām metodēm garīgo vingrinājumu un lūgšanu kreļļu pielietojumam. Darba izveidei veiktas intervijas, literatūras apkopojums un analīze par lūgšanu kreļļu lietojumu kristietībā. Rezultātā, netiek apstiprināta tēze, ka lūgšanu kreļļu nozīme kristietībā ir vienlīdz svarīga kā garīgā, tā arī materiālā aspektā, jo lūgšanu kreļļu būt…

Antivitamin K Drugs in Stroke Prevention

2014

Among the different subtypes of ischaemic strokes, almost 20 % are of cardiac origin. Different are the causes of cardioembolic stroke, but the most common is the atrial fibrillation, a supraventricular arrhythmia. Appropriate use of antiplatelet drugs and anticoagulants after transient ischaemic attack (TIA) or ischaemic stroke depends on whether the underlying cause is cardioembolic or of presumed arterial origin. Adequate antiplatelet therapy is recommended for secondary prevention after cerebral ischaemia of presumed arterial origin, whether for patients with TIA and ischaemic stroke of cardiac origin, mainly due to atrial fibrillation. Vitamin K antagonists (VKAs) are highly effective …

Osobliwosti profesinoj pidgotowki fachiwciw socjalnoj sfery w Ukraini

2018

In the statistics, the actual nutrition of the training equipment of the social sphere. The analysis of the results of the further training of fahіvtsіv, scho held on the basis of the NPU and the names of MP Drahomanov. Awarded in the form of children a yak by a methodical-practical workshop, including a field of training for students in the internship by students of the field of technical skills for the development of professional competencies of social issues of social sciences in the field of art and business, for a new professional foundation for a new career for a new professional for professional development.

PIVKAII Utility in Diagnosis and Post-therapeutic Monitoring of Hepatocellular Carcinoma

Background: Protein induced by vitamin K absence (PIVKA-II), also known as des-gamma-carboxyprothrombin, has been described in relation to HCC being released in association with vitamin K deficiency in the presence of HCC. Serum alpha-fetoprotein (AFP) is the traditional biomarker for HCC detection and follow up but it doesn’t have high sensitivity and specificity. Therefore, there is great interest in identifying new more powerful biomarkers. Materials and methods: One hundred and fourteen subjects were divided into four groups: Group 1 included 58 patients (38M, 20 F) with HCC, mean age 73.5; Group 2 included 38 patients (28M, 10F) with liver cirrhosis (LC), mean age 63.7; Group 3 include…