Search results for "VOLUME"

Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients

2021

Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2- advanced or metastatic breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim of our study was to describe the kinetics of circulating neutrophils from real-life palbociclib-treated patients. A population pharmacokinetic (popPK) model was first constructed to describe palbociclib pharmacokinetic (PK). Individual PK parameters obtained were then used in the pharmacokinetic/pharmacodynamic (PK/PD) model to depict the relation between palbociclib concentrations and absolute neutrophil counts (ANC). The models were built with a population of 143 patients. Palbociclib samples were routinely collec…

IL volume piastrinico medio nei pazienti con febbre mediterranea familiare in età pediatrica

2014

What really causes large price changes?

2003

We study the cause of large fluctuations in prices in the London Stock Exchange. This is done at the microscopic level of individual events, where an event is the placement or cancellation of an order to buy or sell. We show that price fluctuations caused by individual market orders are essentially independent of the volume of orders. Instead, large price fluctuations are driven by liquidity fluctuations, variations in the market's ability to absorb new orders. Even for the most liquid stocks there can be substantial gaps in the order book, corresponding to a block of adjacent price levels containing no quotes. When such a gap exists next to the best price, a new order can remove the best q…

Etude numérique de la convection forcée turbulente dans un dissipateur thermique composé de plusieurs rangées d'ailettes de différentes formes

2016

In this thesis, we present an numerical study of turbulent forced convection in a heat sink provided with a transverse baffle in the bypass. The first model is composed of plates fins and the second consists of adding pin fins between the plates fins. The governing equations, based on the k- SSt turbulence model, are disscredized and solved by the finite volume method and the SIMPLE algorithm. Dynamic results are presented in terms of velocity fields, profiles of the axial velocities in selected sections and pressure drop. The thermal study is presented in terms of temperature fields and the distribution of Nusselt number. A ratio between the thermal and dynamic performances is presented to…

EEG smadzeņu aktivitātes novērtējums trīs-dimensiju attēlu uztverē

2021

Darbs ir uzrakstīts angļu valodā uz 30 lapaspusēm. Tas satur 9 attēlus, 1 tabula un 26 atsauces uz literatūras avotiem. Tā kā trīsdimensiju tehnoloģijas strauji attīstās, pētījumos nepieciešams izvērtēt iekārtas un to mijiedarbību ar cilvēku. Pētījuma mērķis ir novērtēt uzvedības un neirofizioloģiskās iezīmes cilvēkiem, kuri veic uzdevumu izmantojot divas dažādas vizualizācijas: volumetrisko un stereoskopisko. Izmantojot elektroencefalogrāfiju tika reģistrēta smadzeņu aktivitāte un analizēti iegūtie potenciāli un neirālās svārstības. Spēcīgu dziļuma uztveres ietekmi ar abām vizualizācijas tehnoloģijām novēroja tikai vēlīnos uztveres procesos paura garozas reģionā. Turklāt ātrāks reakcijas l…

Numerical and experimental study of hydrostatic displacement machine

2012

This paper presents a simulation tool to determine the structural deflections and corresponding leakage flow in a hydrostatic displacement motor. The simulation tool is applied to a new motor principle that is categorized as an extreme low-speed high-torque motor with dimensions that calls for attention to the volumetric efficiency. To counteract structural deflections the motor is equipped with compensation pressure volumes that may be used to limit the leakage flow across the end faces of the circular rotor. This leakage flow is investigated by solving Reynolds equation for the pressure distribution across both end faces. The fluid pressure is combined with structural calculations in a fl…

Classification of diabetes-related retinal diseases using a deep learning approach in optical coherence tomography

2019

Background and objectives: Spectral Domain Optical Coherence Tomography (SD-OCT) is a volumetric imaging technique that allows measuring patterns between layers such as small amounts of fluid. Since 2012, automatic medical image analysis performance has steadily increased through the use of deep learning models that automatically learn relevant features for specific tasks, instead of designing visual features manually. Nevertheless, providing insights and interpretation of the predictions made by the model is still a challenge. This paper describes a deep learning model able to detect medically interpretable information in relevant images from a volume to classify diabetes-related retinal d…

Theoretical Analysis of Factors Influencing Recovery of Ventilation Distributions from Inert Gas Washout Data

1990

For the quantitative analysis of intraregional ventilation inhomogeneities, one classically applies the inert gas washout method [7,24] in which an inert gas of negligible solubility in blood and tissue is washed into the lungs. After washin is complete, the inspiratory inert gas fraction is set to a smaller value and the time course of the mixed endexpiratory inert gas fraction during the subsequent inert gas washout is recorded. The determinants of this time course are: The endexpiratory alveolar volume at the instant of change in inspiratory inert gas fraction, the anatomical dead space, the gas exchange ratio, the respiratory frequency, the in- and expiratory tidal volumes, and the inho…

Synergistic and Antagonistic Effects of Combined Subzero Temperature and High Pressure on Inactivation of Escherichia coli

2006

ABSTRACT The combined effects of subzero temperature and high pressure on the inactivation of Escherichia coli K12TG1 were investigated. Cells of this bacterial strain were exposed to high pressure (50 to 450 MPa, 10-min holding time) at two temperatures (−20°C without freezing and 25°C) and three water activity levels (a w ) (0.850, 0.992, and ca. 1.000) achieved with the addition of glycerol. There was a synergistic interaction between subzero temperature and high pressure in their effects on microbial inactivation. Indeed, to achieve the same inactivation rate, the pressures required at −20°C (in the liquid state) were more than 100 MPa less than those required at 25°C, at pressures in t…

Analysis of Aggregated Bot and Human Traffic on E-Commerce Site

2014

A significant volume of Web traffic nowadays can be attributed to robots. Although some of them, e.g., search-engine crawlers, perform useful tasks on a website, others may be malicious and should be banned. Consequently, there is a growing need to identify bots and to characterize their behavior. This paper investigates the share of bot-generated traffic on an e-commerce site and studies differences in bots' and humans' session-based traffic by analyzing data recorded in Web server log files. Results show that both kinds of sessions reveal different characteristics, including the session duration, the number of pages visited in session, the number of requests, the volume of data transferre…