Search results for "VP3"

showing 3 items of 3 documents

Mutational analyses of YqjA, a Tvp38/DedA protein of E. coli

2015

AbstractMembrane proteins of the DedA/Tvp38 protein family are involved in membrane integrity and virulence of pathogenic organisms. However, the structure and exact function of any member of this large protein family are still unclear. In the present study we analyzed the functional and structural properties of a DedA homolog. Purified YqjA variants from Escherichia coli are detectable in different oligomeric states and specific homo-interaction of YqjA monomers in the membrane were confirmed by formation of a disulfide bond in the C-terminal transmembrane helix. Moreover, alanine scanning mutagenesis exhibited different interaction sites crucial for YqjA activity vs. dimer formation.

Protein familyDNA Mutational AnalysisBiophysicsVirulencelac operonmedicine.disease_causeBiochemistryProtein Structure SecondaryTvp38Structural BiologyEscherichia coliGeneticsmedicineOligomerizationFunctionMolecular BiologyEscherichia coliAlanineChemistryEscherichia coli ProteinsCell MembraneMutagenesisMembrane ProteinsGene Expression Regulation BacterialCell BiologyAlanine scanningTransmembrane domainMembrane proteinBiochemistryDedAMembrane proteinMutationProtein MultimerizationFEBS Letters
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Apoptosis: a relevant tool for anticancer therapy.

2006

Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment. Defective apoptosis represents a major causative factor in the development and progression of cancer. The majority of chemotherapeutic agents, as well as radiation, utilize the apoptotic pathway to induce cancer cell death. Resistance to standard chemotherapeutic strategies also seems to be due to alterations in the apoptotic pathway of cancer cells. Recent knowledge on apoptosis has provided the basis for novel targeted therapies that exploit apoptosis to treat cancer. These new target include those acting in the ext…

Programmed cell deathSettore MED/06 - Oncologia MedicaSurvivinAntineoplastic AgentsApoptosisLigandsInhibitor of Apoptosis ProteinsBortezomibTNF-Related Apoptosis-Inducing Ligandchemistry.chemical_compoundSulindacExisulindNeoplasmsSurvivinmedicineAnimalsHumansbusiness.industryBortezomibapoptosis TRAIL/Apo2L apoptin/VP3 ONYX015 Bortezomib exisulind survivinCancerReceptors Death DomainHematologymedicine.diseaseBoronic AcidsNeoplasm ProteinsOncologyProteasomechemistryApoptosisPyrazinesCancer cellCancer researchCapsid ProteinsbusinessMicrotubule-Associated Proteinsmedicine.drug
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Genome characterisation of two Ljungan virus isolates from wild bank voles (Myodes glareolus) in Sweden

2015

Ljungan virus (LV) (family Picornaviridae, genus Parechovirus) is a suspected zoonotic pathogen with associations to human disease in Sweden. LV is a single-stranded RNA virus with a positive sense genome. There are five published Ljungan virus strains, three isolated from Sweden and two from America, and are classified into four genotypes. A further two strains described here were isolated from wild bank voles (Myodes glareolus) caught in Vastmanlands county, Sweden in 1994. These strains were sequenced using next generation pyrosequencing technology on the GS454flx platform. Genetic and phylogenetic analysis of the obtained genomes confirms isolates LV340 and LV342 as two new putative mem…

Microbiology (medical)Genes ViralGenotypeGS454ParechovirusGenome ViralMicrobiologyGenomeEvolution MolecularPhylogeneticsUntranslated Regionspositive selectionGenotypeevolutionMyodes glareolusGeneticsAnimalsSelection GeneticMolecular BiologyEcology Evolution Behavior and SystematicsPhylogenyGeneticsSwedenPicornaviridae InfectionsbiologyPhylogenetic treeArvicolinaeta1183RNA virusLjungan virusbiology.organism_classificationVirologyInfectious DiseasesLjungan virusArvicolinaeVP3ParechovirusNucleic Acid ConformationRNA Viralta1181Infection, Genetics and Evolution
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