Search results for "VTA"
showing 5 items of 5 documents
Opposite motor responses elicited by ethanol in the posterior VTA: The role of acetaldehyde and the non-metabolized fraction of ethanol
2013
Recent electrophysiological evidence suggests that ethanol simultaneously exerts opposite effects on the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) through two parallel mechanisms, one promoting and the other reducing the GABA release onto VTA DA neurons. Here we explore the possible behavioural implications of these findings by investigating the role displayed by acetaldehyde (the main metabolite of ethanol) and the non-metabolized fraction of ethanol in motor activity of rats. We analyse the appearance of motor activation or depression after intra-VTA administration of ethanol in rats subjected to different pharmacological pre-treatments designed to preferential…
Systemic administration of D-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats.
2010
Although recently published studies seem to confirm the important role displayed by acetaldehyde (ACH), the main metabolite of ethanol, in the behavioral effects of ethanol, the origin of ACH is still a matter of debate. While some authors confer more importance to the central (brain metabolism) origin of ACH, others indicate that the hepatic origin could be more relevant. In this study we have addressed this topic using an experimental approach that combines local microinjections of ethanol into the ventral tegmental area (VTA) (which guarantees the brain origin of the ACH) to induce motor activation in rats together with systemic administration (i.p.) of several doses (0, 12.5, 25 and 50 …
The LepR-mediated leptin transport across brain barriers controls food reward
2018
Objective Leptin is a key hormone in the control of appetite and body weight. Predominantly produced by white adipose tissue, it acts on the brain to inhibit homeostatic feeding and food reward. Leptin has free access to circumventricular organs, such as the median eminence, but entry into other brain centers is restricted by the blood–brain and blood–CSF barriers. So far, it is unknown for which of its central effects leptin has to penetrate brain barriers. In addition, the mechanisms mediating the transport across barriers are unclear although high expression in brain barriers suggests an important role of the leptin receptor (LepR). Methods We selectively deleted LepR in brain endothelia…
Barns egne stemmer i mekling – En kvalitativ studie av barns erfaringer i obligatorisk mekling etter foreldres samlivsbrudd/skilsmisse
2017
Masteroppgave psykisk helsearbeid ME504 - Universitetet i Agder 2017 Children`s participation in mediation after parent`s brake-up/divorce is a political priori area. Our focus on the importance of preventive work gave us interest in investigating this theme further. The aim was to clarify children`s experiences from participation in mandatory mediation. We focused on how the children`s voices were weighted when the arrangement of care was made, and how the children wanted to be met in mediation. Our research-questions were: «How do children experience their voices being weighted in mandatory mediation after parent`s brake-up/divorce»? and «Which wishes of change in mediation do they tell a…
Konstruksjonen av EØS i norske nettaviser
2016
Masteroppgave samfunnskommunikasjon- Universitetet i Agder, 2016 Det europeiske økonomiske samarbeidsområde (EØS) er Norges tilknytning til EU. Avtalen som sikrer Norge deltakelse i EUs indre marked har vært og er fortsatt et debattert tema hvor det hersker motsetningsfylte meninger om norsk deltakelse. Avtalen i seg selv fremstår som et nasjonalt kompromiss som gjør Norge stadig mer delaktig i den europeiske integrasjonsprosessen. I et journalistisk politisk debattklima som blir stadig mer personifisert, og hvor nettavisene konkurrerer om klikk og sidevisninger, forsøker denne studien å se nærmere på hvordan EØS kommuniseres i norske nettaviser og hva som kjennetegner kommunikasjonen. Gjen…