Search results for "Valuation"
showing 10 items of 2494 documents
New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
2019
The American Society for Pharmacology and Experimental Therapeutics has revised the Instructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to data analysis (including statistical analysis) and reporting but do not tell investigators how to design and perform their experiments. Their overall focus is on greater granularity in the description of what has been done and found. Key recommendations include the need to differentiate between preplanned, hypothesis-testing, and exploratory experiments or studies; explanations of whether key elements of study design, such as sample size and …
Uncertainty evaluation in power measurements with commercial data acquisition boards
2011
The paper deals with the metrological characterization of a digital wattmeter developed by using a personal computer, a shunt, two commercial data acquisition boards and commercial software. The uncertainty of the active power measurements is assessed individually characterizing the voltage channel, the current channel and the phase displacement measurement between the two channels. In particular, the uncertainty on the voltage and current rms measurements is evaluated by using an already proposed approach based on the Monte Carlo method and on the usage of five parameters, while the uncertainty on the phase angle is experimentally estimated. In order to validate the proposed approach for t…
The Model of Possible Web Data Retrieval
2015
In the Dempster-Shafer's theory of evidence, for incorporating uncertainty, the valuation assigns to the data tables the degrees of belief for these data. Firstly, we are looking for the answers to the following questions. Is there a valuation-based system in which combination and marginalization operate on valuations? Has this system prosperities analogical to the t-norm system? In the t-norm system of the valuation for the specific database attributes configuration can be described the algebra of possible data set in which can be interpreted the Information Retrieval Logic.
A Distributed approach to the Remote Control and Programming Improvement
2006
The remote control of industrial plants through networks is becoming very important nowadays but it involves several issues that can degrade the performance and usability of the remote plant. This paper presents a distributed architecture improving a remote programming system which allows users to control and to program a plant remotely. The control system is based on a client/server architecture with many user interfaces that control the plant. The remote programming language is a mix of Java and client/server protocol in order to simplify the developing and to avoid the protocol/language translation. In order to obtain more efficiency, the program is developed in the client side and it is…
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
2014
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment …
Valuation of Barrier Options in a Black-Scholes Setup with Jump Risk
1999
This paper discusses the pitfalls in the pricing of barrier options approximations of the underlying continuous processes via discrete lattice models. These problems are studied first in a Black-Scholes model. Improvements result from a trinomial model and a further modified model where price changes occur at the jump times of a Poisson process. After the numerical difficulties have been resolved in the Black-Scholes model, unpredictable discontinuous price movements are incorporated.
A recurrent deep neural network model to measure sentence complexity for the Italian Language
2019
Text simplification (TS) is a natural language processing task devoted to the modification of a text in such a way that the grammar and structure of the phrases is greatly simplified, preserving the underlying meaning and information contents. In this paper we give a contribution to the TS field presenting a deep neural network model able to detect the complexity of italian sentences. In particular, the system gives a score to an input text that identifies the confidence level during the decision making process and that could be interpreted as a measure of the sentence complexity. Experiments have been carried out on one public corpus of Italian texts created specifically for the task of TS…
How do policies for efficient energy use in the household sector induce energy-efficiency innovation? : An evaluation of European countries
2017
Abstract Research on innovation induced by climate-mitigation policy has been focused predominantly on the supply side of the energy system. Despite considerable climate-mitigation potential on the demand side, less attention is given to the innovation effect of policies addressing the household sector. Based on a comprehensive data set, including 550 policy measures over 30 years (1980–2009) and covering 21 European countries, we find—based on econometric estimations—that policies targeting efficient energy use in the household sector significantly increase the number of patented energy-efficiency inventions. A comparison of the different policy types reveals a particularly strong influenc…
ADM : A Density And Priority Levels Aware Protocol For Broadcasting In Vehicular Ad-Hoc Networks
2014
The broadcasting communication mode is widely used in Vehicular Ad~hoc Networks (VANETs). It is used for sending emergency messages, road-traffic information or to help routing protocols to determine routes. This communication mode is known to be hard to achieve efficiently since it depends on the network density. Indeed, broadcasting methods may cause network congestion if they are not well designed. This paper introduces a novel Autonomic Dissemination Method (ADM) which delivers messages in accordance with given message classes and network density levels. The proposed approach is based on two steps: an offline optimization process and an online adaptation to the network characteristics. …