Search results for "Values"
showing 10 items of 1365 documents
Why should We Bother? Ethical and Social Issues in Individualized Medicine
2006
Individualized medicine, methodologically rooted in pharmacogenetics and pharmacogenomics, is now venturing into clinical application. Prescribing the right drug in the right dose to the right patient according to specific health needs and individual characteristics is a core mission of individualized medicine. The intrinsic values of this mission are so self-evident that--at first glance--the ethical and social issues raised by individualized medicine seem to be negligible. However, the translation of pharmacogenetics and pharmacogenomics into clinical routine not only requires the collection and evaluation of large amounts of individual genetic data, but also heralds the need for further …
Cytotoxic Bufadienolides from the Leaves of Melianthus major
2020
Melianthus major is a medicinal plant endemic to South Africa. Its leaf extract led to the isolation of five new bufadienolides, 2β-acetoxy-3,5-di-O-acetylhellebrigenin (1), 2β-acetoxy-3-O-acetylhellebrigenin (2), 2β-acetoxy-14-deoxy-15β,16β-epoxymelianthugenin (4), 2β-acetoxy-14-deoxy-15β,16β-epoxymelianthusigenin (5), and 2β-hydroxymelianthusigenin (6), and four known analogues. The structures of the compounds were elucidated using NMR and HRESIMS data analyses. The relative configurations were defined by single-crystal X-ray crystallography and NOESY correlations. The isolated compounds exhibited strong cytotoxicity against MCF-7 breast cancer cells and sensitive CCRF-CEM and multidrug-r…
Connecting Berry's phase and the pumped charge in a Cooper pair pump
2003
The properties of the tunnelling-charging Hamiltonian of a Cooper pair pump are well understood in the regime of weak and intermediate Josephson coupling, i.e. when $E_{\mathrm{J}}\lesssim E_{\mathrm{C}}$. It is also known that Berry's phase is related to the pumped charge induced by the adiabatical variation of the eigenstates. We show explicitly that pumped charge in Cooper pair pump can be understood as a partial derivative of Berry's phase with respect to the phase difference $\phi$ across the array. The phase fluctuations always present in real experiments can also be taken into account, although only approximately. Thus the measurement of the pumped current gives reliable, yet indirec…
Temperature dependence of the toxic effects of phenytoin on peripheral neuromuscular function of the rat tail.
1990
We studied the acute effects of a single dose of phenytoin (250 mg/kg) on peripheral neuromuscular function. The evoked muscle action potentials of the dorsal segmental muscles in the rat tail, and the conduction velocity of the dorsal nerve trunk which innervates them, were measured before and after the intraperitoneal injection of phenytoin. The experiments were performed at different temperatures, 27 (physiological tail temperature), 36 and 37 degrees C (physiological central temperature) in different groups of animals. The amplitudes of the evoked muscle action potentials in the treated groups showed no significant modifications at 27 degrees C, at 36 degrees C a small nonsignificant de…
Los rasgos de la ética del humor: Una propuesta a partir de autores contemporáneos
2013
I emphasize some of the contributions of contemporary authors that deal with the issue of humor from an ethical perspective, mainly: Ronald de Sousa, Joseph Boskin, John Morreall, Simon Critchley and Vittorio Hosle. Starting from their thoughts I defend that the «ethics of humor» has, at least, the following features: it helps us to recognize the ethical values in which we really believe, it detects the ethically incorrect humor that maintains stereotypes, it promotes the development of virtues, it criticize the vices of the society contributing to build a more ethical society, and justifies with adequate reasons the laughing that tries to improve ethically our society.
On the equivalence between the Scheduled Relaxation Jacobi method and Richardson's non-stationary method
2017
The Scheduled Relaxation Jacobi (SRJ) method is an extension of the classical Jacobi iterative method to solve linear systems of equations ($Au=b$) associated with elliptic problems. It inherits its robustness and accelerates its convergence rate computing a set of $P$ relaxation factors that result from a minimization problem. In a typical SRJ scheme, the former set of factors is employed in cycles of $M$ consecutive iterations until a prescribed tolerance is reached. We present the analytic form for the optimal set of relaxation factors for the case in which all of them are different, and find that the resulting algorithm is equivalent to a non-stationary generalized Richardson's method. …
Extension of the Launay Quantum Reactive Scattering Code and Direct Computation of Time Delays.
2019
Scattering computations, particularly within the realm of molecular physics, have seen an increase in study since the development of powerful quantum methods. These dynamical processes can be analyzed via (among other quantities) the duration of the collision process and the lifetime of the intermediate complex. We use the Smith matrix Q = -iℏS†dS/dE calculated from the scattering matrix S and its derivative with respect to the total energy. Its real part contains the state-to-state time delays, and its eigenvalues give the lifetimes of the metastable states [ Smith Phys. Rev. 1960 , 118 , 349 - 356 ]. We propose an extension of the Launay HYP3D code [ Launay and Le Dourneuf Chem. Phys. Let…
Solution for an arbitrary number of coupled identical oscillators.
1992
We propose a solution to the problem of solving the Schr\"odinger equation for an arbitrary number of identical one-dimensional harmonically coupled oscillators raised by Fan Hong-yi [Phys. Rev. A 42, 4377 (1990)]. The relationship between the Fock spaces associated with the uncoupled and coupled oscillators is given as well as the coordinate representation of the eigenstates. In view of further applications, the Lie algebraic properties of the model are examined, and the generalization to three spatial dimensions is made.
Preparation of macroscopically distinguishable superpositions of circular or linear oscillatory states of a bidimensionally trapped ion
2000
A simple scheme for the generation of two different classes of bidimensional vibrational Schrodinger cat-like states of an isotropically trapped ion is presented. We show that by appropriately adjusting an easily controllable parameter having a clear physical meaning, the states prepared by our procedure are quantum superpositions of either vibrational axial angular momentum eigenstates or Fock states along two orthogonal directions.
A nonlinear eigenvalue problem for the periodic scalar p-Laplacian
2014
We study a parametric nonlinear periodic problem driven by the scalar $p$-Laplacian. We show that if $\hat \lambda_1 >0$ is the first eigenvalue of the periodic scalar $p$-Laplacian and $\lambda> \hat \lambda_1$, then the problem has at least three nontrivial solutions one positive, one negative and the third nodal. Our approach is variational together with suitable truncation, perturbation and comparison techniques.