Search results for "Variable"

Estimates for the first and second Bohr radii of Reinhardt domains

2004

AbstractWe obtain general lower and upper estimates for the first and the second Bohr radii of bounded complete Reinhardt domains in Cn.

Split-Way CVTs: Parametric Analysis and Design

The thesis provides a parametric analytical method for the analysis and design of power-split continuously variable transmissions, which represent the state of the art for heavy-duty vehicles and hybrid electric cars. The functioning of any driveline is described by mean of a simple set of kinematic parameters, regardless of the constructive scheme. The calculation of the control torques remains straightforward even when both inertial effects and mechanical losses are taken into account. A simple design procedure is described and generalized in order to address any order of driveline, including multimode transmissions. The final layout is generated additively, without the need to analyze hu…

Analysis of complex singularities in high-Reynolds-number Navier-Stokes solutions

2013

AbstractNumerical solutions of the laminar Prandtl boundary-layer and Navier–Stokes equations are considered for the case of the two-dimensional uniform flow past an impulsively-started circular cylinder. The various viscous–inviscid interactions that occur during the unsteady separation process are investigated by applying complex singularity analysis to the wall shear and streamwise velocity component of the two solutions. This is carried out using two different methodologies, namely a singularity-tracking method and the Padé approximation. It is shown how the van Dommelen and Shen singularity that occurs in solutions of the Prandtl boundary-layer equations evolves in the complex plane be…

Symptoms and the body: Taking the inferential leap

2017

The relationship between the conscious experience of physical symptoms and indicators of objective physiological dysfunction is highly variable and depends on characteristics of the person, the context and their interaction. This relationship often breaks down entirely in the case of "medically unexplained" or functional somatic symptoms, violating the basic assumption in medicine that physical symptoms have physiological causes. In this paper, we describe the prevailing theoretical approach to this problem and review the evidence pertaining to it. We then use the framework of predictive coding to propose a new and more comprehensive model of the body-symptom relationship that integrates ex…

Probabilistic inference of approximations

2006

We consider probabilistic inductive inference of Godel numbers of total recursive functions when the set of possible errors is allowed to be infinite, but with bounded density. We have obtained hierarchies of classes of functions identifiable with different probabilities up to sets with fixed density. The obtained hierarchies turn out to be different from those which we have in the case of exact identification.

Black German identities

2009

This study examines the reliability and validity of a German version of the Multidimensional Inventory of Black Identity (MIBI) in a sample of 170 Black Germans. The internal consistencies of all subscales are at least moderate. The factorial structure of the MIBI, as assessed by principal component analysis, corresponds to a high degree to the supposed underlying dimensional structure. Construct validity was examined by analyzing (a) the intercorrelations of the MIBI subscales and (b) the correlations of the subscales with external variables. Predictive validity was assessed by analyzing the correlations of three MIBI subscales with the level of intra-racial contact. All but one predictio…

Comparative evaluation of three semi-quantitative radiographic grading techniques for knee osteoarthritis in terms of validity and reproducibility in…

2008

OBJECTIVE: The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods of knee osteoarthritis (OA), both on semiflexed and extended views. METHODS: In data obtained from trials and cohorts, X-rays were graded using Kellgren and Lawrence (KL), the OA Research Society International (OARSI) joint space narrowing score, and measurement of joint space width (JSW). JSW was analyzed as a categorical variable. Construct validity was assessed through logistic regression between X-ray stages and Western Ontario and McMaster Universities OA Index. Inter-observer reliability was assessed in 50 subjects for extended views by weighted kappa. Intra-obser…

Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other…

2008

Contains fulltext : 69677.pdf (Publisher’s version ) (Closed access) A major goal of genetic studies of attention deficit hyperactivity disorder (ADHD) is to identify individual characteristics that might help segregate the disorder's inherent heterogeneity. [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] recently reported a potentially important association between two dopamine-related risk polymorphisms (DRD4 variable number tandem repeat (VNTR) in exon 3 and DAT1 VNTR in the 3' UTR) and lowered IQ in ADHD. The objective of the current study was to replicate the [Mill et al. (2006); Arch Ger Psychiatry 63:462-469] findings in a clinical sample and to extend the analysis to a large ra…

Inheritance and variable expression in Rubinstein-Taybi syndrome.

2010

Familial Rubinstein-Taybi syndrome (RTS) is very rare. Here we report on the 6th and 7th case of inherited RTS. Family 1 presents with incomplete or mild RTS over three generations; a 13-year-old girl (proband 1) with mild but typical facial features and learning disabilities, her very mildly affected mother (proband 2), and the maternal grandmother (proband 3). Family 2 includes three females with classical RTS (probands 4-6) and their father (proband 7) with broad thumbs and halluces. Proband 5 also had a brain tumor (ganglioglioma) at the age of 3 years. In probands 1-3, direct sequencing identified a novel CREBBP missense mutation, c.2728A > G (predicting p.Thr910Ala), that was absent i…

Incretin-Based Therapies Role in COVID-19 Era: Evolving Insights

2020

The current coronavirus disease 2019 (COVID-19) pandemic has led the scientific community to breach new frontiers in the understanding of human physiology and disease pathogenesis. It has been hypothesized that the human dipeptidyl peptidase 4 (DPP4) enzyme receptor may be a functional target for the spike proteins of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Since DPP4-inhibitors are currently used for the treatment of patients with type-2 diabetes (T2DM), there is currently high interest in the possibility that these agents, or incretin-based therapies (IBTs) in general, may be of benefit against the new coronavirus infection. Diabetes is associated with increased COV…