Search results for "Variable"
showing 10 items of 1674 documents
Variable-order reference-free variant discovery with the Burrows-Wheeler Transform
2020
Abstract Background In [Prezza et al., AMB 2019], a new reference-free and alignment-free framework for the detection of SNPs was suggested and tested. The framework, based on the Burrows-Wheeler Transform (BWT), significantly improves sensitivity and precision of previous de Bruijn graphs based tools by overcoming several of their limitations, namely: (i) the need to establish a fixed value, usually small, for the order k, (ii) the loss of important information such as k-mer coverage and adjacency of k-mers within the same read, and (iii) bad performance in repeated regions longer than k bases. The preliminary tool, however, was able to identify only SNPs and it was too slow and memory con…
Determinantes de la estructura de vencimiento de la deuda en las empresas no cotizadas de los sectores industrial y de la construcción en Colombia de…
2017
Este artículo de reflexión explora, analiza y formula evidencias empíricas en torno a las variables determinantes del plazo del endeudamiento (corto plazo) de las empresas no cotizadas de los sectores industrial y de la construcción en Colombia para el periodo de 2008 a 2014. De acuerdo con el procesamiento de la información contable y financiera anual de las empresas de estos sectores que están reportadas en el Sistema de Información y Reporte Empresarial (Sirem) de la Superintendencia de Sociedades, se construye una base de datos con dos paneles desbalanceados para cada sector. Posteriormente, dicha información es modelada estocásticamente, estimándose las variables para cada sector por m…
Relationship between score and coaches’ verbal behavior
2013
Calpe V, Guzman J, Grijalbo C. Relationship between score and coaches’ verbal behaviour. J. Hum. Sport Exerc. Vol. 8, No. Proc3, pp. S728-S737, 2013. The way the coach act the most during the development of the game is meanwhile verbal behaviour directed to their players (Moreno et al., 2000), being it influenced by his own cognitions, motivations, and emotions, together with players behaviours and playing situation (Borrie, 1996; Smoll & Smith, 1989). The aim of this study was to analyse the relationship between a situational variable, the score during the game, and verbal behaviour of handball coaches in competitive situation. To do this, five coaches were analysed in five games. Two vari…
Molecular Basis for the Interaction of the Hepatitis B Virus Core Antigen with the Surface Immunoglobulin Receptor on Naive B Cells
2001
ABSTRACTThe nucleocapsid of the hepatitis B virus (HBV) is composed of 180 to 240 copies of the HBV core (HBc) protein. HBc antigen (HBcAg) capsids are extremely immunogenic and can activate naive B cells by cross-linking their surface receptors. The molecular basis for the interaction between HBcAg and naive B cells is not known. The functionality of this activation was evidenced in that low concentrations of HBcAg, but not the nonparticulate homologue HBV envelope antigen (HBeAg), could prime naive B cells to produce anti-HBc in vitro with splenocytes from HBcAg- and HBeAg-specific T-cell receptor transgenic mice. The frequency of these HBcAg-binding B cells was estimated by both hybridom…
Measuring Observable Quantum Contextuality
2016
Contextuality is a central property in comparative analysis of classical, quantum, and supercorrelated systems. We examine and compare two well-motivated approaches to contextuality. One approach (“contextuality-by-default”) is based on the idea that one and the same physical property measured under different conditions (contexts) is represented by different random variables. The other approach is based on the idea that while a physical property is represented by a single random variable irrespective of its context, the joint distributions of the random variables describing the system can involve negative (quasi-)probabilities. We show that in the Leggett-Garg and EPR-Bell systems, the two …
Monogamy Inequality for Distributed Gaussian Entanglement
2007
We show that for all n-mode Gaussian states of continuous variable systems, the entanglement shared among n parties exhibits the fundamental monogamy property. The monogamy inequality is proven by introducing the Gaussian tangle, an entanglement monotone under Gaussian local operations and classical communication, which is defined in terms of the squared negativity in complete analogy with the case of n-qubit systems. Our results elucidate the structure of quantum correlations in many-body harmonic lattice systems.
Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tum…
2021
Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the target of interest, site-specific conjugation of these functional groups is preferred. Here, we optimized site-specific conjugation of both a chelator for binding of a radiometal and a photosensitizer to epidermal growth factor receptor (EGFR) binding VHH 7D12. We characterized this dual-labeled VHH for nuclear imaging and targeted photodynamic therapy of EGFR-expressing tumors. Abstract Variable domains of heavy chain only antibodies (VHHs) are valu…
Immunohistochemical evaluation of growth fractions in human breast cancers using monoclonal antibody Ki-67.
1991
We performed immunohistochemical analyses of 568 breast/cancer specimens using Ki-67, a monoclonal antibody specific for a nuclear antigen present in proliferating cells. The specimens were divided into three groups (I-III) according to the proportion of Ki-positive cells detected. These findings were compared with features of tumor extension as well as with certain prognostic variables. There was no detectable correlation between Ki-67 reactivity and either tumor size or node involvement. In contrast, a statistically significant correlation was found between Ki-67 reactivity and tumor grading, in that G-I tumors had small growth fractions, while a high proportion of G-III tumors exhibited …
Hyperspectral UAV-Imagery and photogrammetric canopy height model in estimating forest stand variables
2017
Remote sensing using unmanned aerial vehicle (UAV) -borne sensors is currently a highly interesting approach for the estimation of forest characteristics. 3D remote sensing data from airborne laser scanning or digital stereo photogrammetry enable highly accurate estimation of forest variables related to the volume of growing stock and dimension of the trees, whereas recognition of tree species dominance and proportion of different tree species has been a major complication in remote sensing-based estimation of stand variables. In this study the use of UAV-borne hyperspectral imagery was examined in combination with a high-resolution photogrammetric canopy height model in estimating forest v…
Abstract PO-35: Prognostic significance of MYC, BCL2, and BCL6 colocalization at single-cell resolution in DLBCL
2020
Abstract MYC, BCL2, and BCL6 are commonly used markers for immunohistochemistry of Diffuse large B-cell lymphomas (DLBCL). Coexpression of MYC and BCL2 in particular constitutes a subgroup of “double expressor lymphomas” (DEL) with a distinct poor clinical outcome. However, it is not known if MYC and BCL2/BCL6 coexpression occurs in the same cell or in different cells within the tumor, as traditional immunohistochemistry (IHC) is limited by the number of markers that can be simultaneously assessed within formalin-fixed, paraffin-embedded (FFPE) samples. We set out to discover the clinical significance of MYC, BCL2, and BCL6 colocalization at single-cell resolution using multiplexed quantita…