Search results for "Vasorelaxation"

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Vasoactive properties of antihypertensive lactoferrin-derived peptides in resistance vessels: Effects in small mesenteric arteries from SHR rats

2017

Aims: Bovine lactoferrin (LF) hydrolysates and peptides identified thereof have shown antihypertensive effects in rat models, mainly but not exclusively by angiotensin-converting enzyme inhibition. In this study we aimed to assess the vasoactive effects and mechanisms of an ultrafiltered (< 3 kDa) pepsin LF hydrolysate (LFH) and a heptapeptide identified in a LF hydrolysate produced by yeast proteolysis (DPYKLRP) in peripheral resistance arteries from spontaneously hypertensive rats (SHRs). Main methods: We used a myograph system for isometric tension recording in isolated small mesenteric arteries from SHRs. Direct vasoactive effects of LFH (30–100 μg/mL) and DPYKLRP (30–100 μM) were asses…

Male0301 basic medicinemedicine.medical_specialtyProtein HydrolysatesAntihypertensive effectsBlood PressureLactoferrin-derived peptidesIn Vitro TechniquesGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesSpontaneously hypertensive ratIn vivoRats Inbred SHRInternal medicinemedicineAnimalsGeneral Pharmacology Toxicology and PharmaceuticsPhenylephrineMesenteric arteriesAntihypertensive AgentsSpontaneously hypertensive rat030109 nutrition & dieteticsDose-Response Relationship Drugbiologybusiness.industryMesenteric arteryVasorelaxationGeneral MedicineAction mechanismMesenteric ArteriesVasodilationLactoferrinEndocrinologymedicine.anatomical_structureHypertensionbiology.proteinVascular ResistanceCyclooxygenaseSodium nitroprussidebusinessOligopeptidesAcetylcholinemedicine.drugMyograph
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