Search results for "Vector"
showing 10 items of 2660 documents
Application of molecular topology to the prediction of potency and selection of novel insecticides active against malaria vectors
2005
Abstract A study on the basis of molecular topology has been carried out to predict the potency of insecticides active against malaria vectors (Culex) as well as to select novel compounds potentially active on those vectors. The results, performed over two sets of compounds, namely hormone-like and ‘common’ or wide-spectra insecticides, demonstrate that the adequate combination of topological charge indices and simple topological-geometric indices, yield very good results in both, the prediction of potency and the selection of new insecticides. Further development should be addressed in the future; however, the achievement described here is extremely encouraging.
Predictive modeling of aryl hydrocarbon receptor (AhR) agonism
2020
Abstract The aryl hydrocarbon receptor (AhR) plays a key role in the regulation of gene expression in metabolic machinery and detoxification systems. In the recent years, this receptor has attracted interest as a therapeutic target for immunological, oncogenic and inflammatory conditions. In the present report, in silico and in vitro approaches were combined to study the activation of the AhR. To this end, a large database of chemical compounds with known AhR agonistic activity was employed to build 5 classifiers based on the Adaboost (AdB), Gradient Boosting (GB), Random Forest (RF), Multilayer Perceptron (MLP) and Support Vector Machine (SVM) algorithms, respectively. The built classifier…
Lévy walks and scaling in quenched disordered media.
2010
We study L\'evy walks in quenched disordered one-dimensional media, with scatterers spaced according to a long-tailed distribution. By analyzing the scaling relations for the random-walk probability and for the resistivity in the equivalent electric problem, we obtain the asymptotic behavior of the mean square displacement as a function of the exponent characterizing the scatterers distribution. We demonstrate that in quenched media different average procedures can display different asymptotic behavior. In particular, we estimate the moments of the displacement averaged over processes starting from scattering sites, in analogy with recent experiments. Our results are compared with numerical…
Lévy flights in an infinite potential well as a hypersingular Fredholm problem.
2016
We study L\'evy flights {{with arbitrary index $0< \mu \leq 2$}} inside a potential well of infinite depth. Such problem appears in many physical systems ranging from stochastic interfaces to fracture dynamics and multifractality in disordered quantum systems. The major technical tool is a transformation of the eigenvalue problem for initial fractional Schr\"odinger equation into that for Fredholm integral equation with hypersingular kernel. The latter equation is then solved by means of expansion over the complete set of orthogonal functions in the domain $D$, reducing the problem to the spectrum of a matrix of infinite dimensions. The eigenvalues and eigenfunctions are then obtained numer…
Solving fractional Schroedinger-type spectral problems: Cauchy oscillator and Cauchy well
2014
This paper is a direct offspring of Ref. [J. Math. Phys. 54, 072103, (2013)] where basic tenets of the nonlocally induced random and quantum dynamics were analyzed. A number of mentions was maid with respect to various inconsistencies and faulty statements omnipresent in the literature devoted to so-called fractional quantum mechanics spectral problems. Presently, we give a decisive computer-assisted proof, for an exemplary finite and ultimately infinite Cauchy well problem, that spectral solutions proposed so far were plainly wrong. As a constructive input, we provide an explicit spectral solution of the finite Cauchy well. The infinite well emerges as a limiting case in a sequence of deep…
Pion electroproduction, partially conserved axial-vector current, chiral Ward identities, and the axial form factor revisited
2003
We reinvestigate Adler's partially conserved axial-vector current relation in the presence of an external electromagnetic field within the framework of QCD coupled to external fields. We discuss pion electroproduction within a tree-level approximation to chiral perturbation theory and explicitly verify a chiral Ward identity referred to as the Adler-Gilman relation. We critically examine soft-momentum techniques and point out how inadmissable approximations may lead to results incompatible with chiral symmetry. As a result we confirm that threshold pion electroproduction is indeed a tool to obtain information on the axial form factor of the nucleon.
The spin-dependent structure function of the proton g1p and a test of the Bjorken sum rule
2010
Abstract The inclusive double-spin asymmetry, A 1 p , has been measured at COMPASS in deep-inelastic polarised muon scattering off a large polarised NH3 target. The data, collected in the year 2007, cover the range Q 2 > 1 ( GeV / c ) 2 , 0.004 x 0.7 and improve the statistical precision of g 1 p ( x ) by a factor of two in the region x 0.02 . The new proton asymmetries are combined with those previously published for the deuteron to extract the non-singlet spin-dependent structure function g 1 NS ( x , Q 2 ) . The isovector quark density, Δ q 3 ( x , Q 2 ) , is evaluated from a NLO QCD fit of g 1 NS . The first moment of Δ q 3 is in good agreement with the value predicted by the Bjorken su…
Exclusive radiative decays of W and Z bosons in QCD factorization
2015
We present a detailed theoretical analysis of very rare, exclusive hadronic decays of the electroweak gauge bosons V=W, Z from first principles of QCD. Our main focus is on the radiative decays V->M+gamma, in which M is a pseudoscalar or vector meson. At leading order in an expansion in powers of Lambda_{QCD}/m_V the decay amplitudes can be factorized into convolutions of calculable hard-scattering coefficients with the leading-twist light-cone distribution amplitude of the meson M. Power corrections to the decay rates arise first at order (Lambda_{QCD}/m_V)^2. They can be estimated in terms of higher-twist distribution amplitudes and are predicted to be tiny. We include one-loop O(alpha…
An experimental study of γγ → hadrons at LEP
1993
An analysis of γγ interactions has been performed using untagged hadronic data obtained by the ALEPH detector at LEP. The data show at low transverse momentum (pt) are well reproduced by a model based on the vector meson dominance mechinism (VDM). At high pt thrust the presence of hard scattering processes is demonstrated. This component is well described in shape and normalization by a QCD calculation.
Linear Wave Equations and Effective Lagrangians for Wigner Supermultiplets
1995
The relevance of the contracted SU(4) group as a symmetry group of the pion nucleon scattering amplitudes in the large $N_c$ limit of QCD raises the problem on the construction of effective Lagrangians for SU(4) supermultiplets. In the present study we suggest effective Lagrangians for selfconjugate representations of SU(4) in exploiting isomorphism between so(6) and ist universal covering su(4). The model can be viewed as an extension of the linear $\sigma$ model with SO(6) symmetry in place of SO(4) and generalizes the concept of the linear wave equations for particles with arbitrary spin. We show that the vector representation of SU(4) reduces on the SO(4) level to a complexified quatern…