Search results for "Ventral"

Salsolinol and ethanol-derived excitation of dopamine mesolimbic neurons: new insights

2013

Evidence supporting the essential role of brain-derived ethanol metabolites in the excitation of dopamine (DA) midbrain neurons has multiplied in the last 10–15 years. The pioneer and influential behavioral studies by CM Aragon and colleagues (see Correa et al., 2012 for a complete review) and more recent data (Sanchez-Catalan et al., 2009; Marti-Prats et al., 2010, 2013) have repeatedly demonstrated the crucial role displayed by acetaldehyde (ACD) in the locomotor and other behavioral responses elicited by ethanol. Although these experiments mainly used an indirect measure (exploratory locomotion) as an index of the excitation of DA neurons in the ventral tegmental area (VTA), results stro…

Thalamic Network Oscillations Synchronize Ontogenetic Columns in the Newborn Rat Barrel Cortex

2013

Neocortical areas are organized in columns, which form the basic structural and functional modules of intracortical information processing. Using voltage-sensitive dye imaging and simultaneous multi-channel extracellular recordings in the barrel cortex of newborn rats in vivo, we found that spontaneously occurring and whisker stimulation-induced gamma bursts followed by longer lasting spindle bursts were topographically organized in functional cortical columns already at the day of birth. Gamma bursts synchronized a cortical network of 300-400 µm in diameter and were coherent with gamma activity recorded simultaneously in the thalamic ventral posterior medial (VPM) nucleus. Cortical gamma b…

The Interaction of Person-Affect-Cognition-Execution (I-PACE) model for addictive behaviors: Update, generalization to addictive behaviors beyond int…

2019

We propose an updated version of the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, which we argue to be valid for several types of addictive behaviors, such as gambling, gaming, buying-shopping, and compulsive sexual behavior disorders. Based on recent empirical findings and theoretical considerations, we argue that addictive behaviors develop as a consequence of the interactions between predisposing variables, affective and cognitive responses to specific stimuli, and executive functions, such as inhibitory control and decision-making. In the process of addictive behaviors, the associations between cue-reactivity/craving and diminished inhibitory control contribute to th…

The Argument Dependency Model

2015

This chapter summarizes the architecture of the extended Argument Dependency Model (eADM), a model of language comprehension that aspires toward neurobiological plausibility. It combines design principles from neurobiology with insights on cross-linguistic diversity. Like other current models, the eADM posits that auditory language processing proceeds along two distinct streams in the brain emanating from auditory cortex: the antero-ventral and postero-dorsal streams. Both streams are organized hierarchically and information processing takes place in a cascaded fashion. Each stream has functionally unified computational properties congruent with its role in primate audition. While the dorsa…

Letter: Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor…

2017

Colours of quality: structural (but not pigment) coloration informs about male quality in a polychromatic lizard

2014

Chromatic signals result from the differential absorption of light by chemical compounds (pigment-based colours) and/or from differential scattering of light by integument nanostructures (structural colours). Both structural and pigment-based colours can be costly to produce, maintain and display, and have been shown to convey information about a variety of individual quality traits. Male wall lizards, Podarcis muralis, display conspicuously coloured ventral and lateral patches during ritualized inter- and intrasexual displays: ventral colours (perceived as orange, yellow or white by humans) are pigment based, while the ultraviolet (UV)-blue of the outer ventral scales (OVS), located along …

Author response: Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo

2014

Anomalies in Sepiolinae hectocotylization

1997

Four cases of anomalies of the copulatory arm in Sepiolinae (Cephalopoda: Sepiolidae) are reported. In one case (Sepietta oweniana), both dorsal arms were modified resulting in double hecocotylization. In another specimen probably of the same species the copula-tory apparatus was formed by two fleshy multilobed formations situated on the dorsal and ventral side of the arm base. In one specimen of Rondeletiola minor the copulatory apparatus was inversely positioned on the arm base, and in one Sepioh intermedia specimen the inner free portion of the wrinkled tubercle was markedly enlarged.

Cross-reinstatement between 3,4-methylenedioxypyrovalerone (MDPV) and cocaine using conditioned place preference.

2019

Abstract 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) considered to be a cocaine-like psychostimulant. The substitution of an established illicit drug as cocaine with an NPS is a pattern of use reported among drug users. The aim of this study was to investigate the relationship between cocaine and MDPV in the reinstatement of the conditioned place preference (CPP) paradigm, in order to establish whether there is cross-reinstatement between the two psychostimulants. Four experimental groups of male OF1 mice were subjected to the CPP paradigm: MDPV-MDPV, Cocaine-Cocaine, Cocaine-MDPV, and MDPV-Cocaine. The first drug refers to the substance with which the animal…

Pre-Clinical Studies with D-Penicillamine as a Novel Pharmacological Strategy to Treat Alcoholism: Updated Evidences

2017

Ethanol, as other drugs of abuse, is able to activate the ventral tegmental area dopamine (VTA-DA) neurons leading to positively motivational alcohol-seeking behavior and use, and, ultimately to ethanol addiction. In the last decades, the involvement of brain-derived acetaldehyde (ACD) in the ethanol actions in the mesolimbic pathway has been widely demonstrated. Consistent published results have provided a mechanistic support to the use of ACD inactivating agents to block the motivational and reinforcing properties of ethanol. Hence, in the last years, several pre-clinical studies have been performed in order to analyze the effects of the sequestering ACD agents in the prevention of ethano…