Search results for "Vertebrate"

The immune mediators in echinoderms as souce of novel AMPs against microbial biofilms

2012

Screening of fractions from marine sponges and other invertebrates to identify new lead compounds with anti-tumor activity in lymphoma models

2020

Diffuse large B-cell lymphoma (DLBCL) is the commonest type of lymphomas, accounting for 30%-40% of new cases each year. Despite the big improvements achieved in the treatment, still 25–40% of patients still succumb due to refractory or relapsed disease. This highlights the need of new drugs for this cancer. The marine environment has recently been recognized as a source of anti-cancer compounds, as demonstrated by different marine drugs approved by different regulatory agencies (trabectedin, cytarabine, eribulin, plitidepsin) or as components of antibody drug conjugates for lymphoma patients (monomethyl auristatin E in polatuzumab vedotin and brentuximab vedotin). Here, we present a large …

Cloning of Two Putative Ecdysteroid Receptor Isoforms from Tenebrio Molitor and their Developmental Expression in the Epidermis during Metamorphosis

1997

Using the Drosophila EcR-B1 cDNA as a probe, we have cloned the putative ecdysteroid receptor from the mealworm Tenebrio molitor. We have isolated two cDNAs with different 5' termini that contain a complete open reading frame. These two cDNAs encode two proteins with distinct N-terminal regions corresponding to two isoforms. The coleopteran receptor is obviously related to the ecdysteroid receptor of other insects, but shares only 89% and 61% amino acid identities with the DNA-binding and ligand-binding domains of the Drosophila receptor, respectively. Its expression pattern has been examined in the epidermis during the last larval instar and pupal stage of T. molitor, in correlation with t…

Temporal patterns in immune responses to a range of microbial insults (Tenebrio molitor).

2008

8 pages; International audience; Much work has elucidated the pathways and mechanisms involved in the production of insect immune effector systems. However, the temporal nature of these responses with respect to different immune insults is less well understood. This study investigated the magnitude and temporal variation in phenoloxidase and antimicrobial activity in the mealworm beetle Tenebrio molitor in response to a number of different synthetic and real immune elicitors. We found that antimicrobial activity in haemolymph increased rapidly during the first 48h after a challenge and was maintained at high levels for at least 14 days. There was no difference in the magnitude of responses …

Phylogeography and demographic inference in Nacella (Patinigera) concinna (Strebel, 1908) in the western Antarctic Peninsula

2011

10 pages; International audience; Endemic to Antarctic ecosystems, the limpet Nacella (Patinigera) concinna (Strebel, 1908) is an abundant and dominant marine benthic invertebrate of the intertidal and shallow subtidal zone. In order to examine the phylogeographic pattern and historical demography of the species along the western Antarctic Peninsula, we amplified 663 bp of the mitochondrial DNA cytochrome oxidase subunit I of 161 N. concinna specimens from five localities, as well as two specimens from South Georgia and Sub-Antarctic Marion Island. As two different morphotypes, one characterized by an elevated shell in the intertidal and the other by a flat one in the subtidal, have been re…

New insights into the gut microbiome in loggerhead sea turtles Caretta caretta stranded on the Mediterranean coast

2019

Caretta caretta is the most common sea turtle species in the Mediterranean Sea. The species is threatened by anthropomorphic activity that causes thousands of deaths and hundreds of strandings along the Mediterranean coast. Stranded turtles are often cared for in rehabilitation centres until they recover or die. The objective of this study was to characterize the gut microbiome of nine sea turtles stranded along the Sicilian coast of the Mediterranean Sea using high-throughput sequencing analysis targeting V3–V4 regions of the bacterial 16S rRNA gene. Stool samples were collected from eight specimens hosted in the recovery centre after a few days of hospitalization (under 7) and from one ho…

Coastal Evolution in a Mediterranean Microtidal Zone: Mid to Late Holocene Natural Dynamics and Human Management of the Castellò Lagoon, NE Spain

2016

We present a palaeoenvironmental study of the Castelló lagoon (NE Spain), an important archive for understanding long-term interactions between dynamic littoral ecosystems and human management. Combining geochemistry, mineralogy, ostracods, diatoms, pollen, non-pollen palynomorphs, charcoal and archaeo-historical datasets we reconstruct: 1) the transition of the lagoon from a marine to a marginal environment between ~3150 cal BC to the 17th century AD; 2) fluctuations in salinity; and 3) natural and anthropogenic forces contributing to these changes. From the Late Neolithic to the Medieval period the lagoon ecosystem was driven by changing marine influence and the land was mainly exploited …

Antitumoral compounds from vertebrate sister group: A review of Mediterranean ascidians

2020

Among the diseases that afflict the human population, cancer is one for which many drug treatments are not yet known or effective. Moreover, the pharmacological treatments used often create serious side effects in sick patients and for this reason, it is essential to find effective and less harmful treatments. To date, marine biodiversity is a real source of metabolites with antitumoral activity and among invertebrates' ascidians have been the main source to obtain them. Mediterranean area is the richest in biodiversity and contains several ascidian species used in drugs development during the years. However, many more Mediterranean ascidian species have not been studied and could be a sour…

Microplastics ingestion by the exotic fish Gambusia holbrooki in two Mediterranean coastal lagoons

2020

Gambusia holbrooki es un pequeño pez Poecílido, de origen norteamericano que fue introducido a principios del siglo XX en humedales de la Península Ibérica para el control biológico de los mosquitos. Actualmente presenta poblaciones en muchos humedales y está considerada como una de las principales especies invasoras en la península. Estos peces se alimentan principalmente de invertebrados, pero son también susceptibles de ingerir y acumular residuos de microplásticos que presentan tamaños similares al tamaño de algunas de sus presas habituales. En el presente estudio analizamos los contenidos del tracto gastrointestinal de ejemplares adultos de esta especie, procedentes de dos lagunas cost…

Invertebrate community responses to emerging water pollutants in Iberian river basins

2014

Abstract Chemical pollution is one of the greatest threats to freshwater ecosystems, especially in Mediterranean watersheds, characterized by periodical low flows that may exacerbate chemical exposure. Different groups of emerging pollutants have been detected in these basins during the last decade. This study aims to identify the relationships between the presence and levels of prioritary and emerging pollutants (pesticides, pharmaceutical active compounds—PhACs, Endocrine Disrupting Compounds EDCs and Perfluorinated Compounds—PFCs) and the invertebrate community in four Mediterranean basins: the Ebro, the Llobregat, the Jucar and the Guadalquivir. Structural (species composition and densi…