Search results for "Vial"
showing 10 items of 408 documents
Discharge data series of Begura de Salma River (Mallorca, Spain): January 2015-October 2018
2020
Here we provide the data set obtained as described in detail in Estrany et al. (2020, doi:10.5194/nhess-2019-304); a brief description is presented below. A hydrometric gauging station is located where the Begura de Salma River enters Sant Llorenç des Cardassar, a village located in the northeastern part of Mallorca island (Spain). The station was built by the water authority in the 1970s. After years of abandonment, in 2015 the MEDhyCON Research Group installed within the gauge house a Hobo Water Level U20L-04, which measures the water stage by 1-minute readings, accumulating 15-minute average values. The station is located at the very beginning of the concrete channel that takes the river…
Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.
1998
We have synthesized analogues of two naturally occurring antiinflammatory marine compounds, manoalide and cacospongionolide B, containing a pyranofuranone moiety which is considered the pharmacophoric group. The two compounds, and hence their analogues, differ in the presence or absence in the dihydropyran ring of an hemiacetal function which was considered essential to irreversibly inactivate phospholipase A 2 (PLA 2 ). The two series of compounds were tested for their inhibitory effects on secretory PLA 2 belonging to the groups I, II, and III, and the activities were found to be similar in both series, irrespective of the presence or absence of the additional hemiacetal function. In addi…
Equivariant Triviality of Quasi-Monomial Triangular $$\mathbb{G}_{a}$$-Actions on $$\mathbb{A}^{4}$$
2014
We give a direct and self-contained proof of the fact that additive group actions on affine four-space generated by certain types of triangular derivations are translations whenever they are proper. The argument, which is based on explicit techniques, provides an illustration of the difficulties encountered and an introduction to the more abstract methods which were used recently by the authors to solve the general triangular case.
On i-topological spaces: generalization of the concept of a topological space via ideals
2006
[EN] The aim of this paper is to generalize the structure of a topological space, preserving its certain topological properties. The main idea is to consider the union and intersection of sets modulo “small” sets which are defined via ideals. Developing the concept of an i-topological space and studying structures with compatible ideals, we are concerned to clarify the necessary and sufficient conditions for a new space to be homeomorphic, in some certain sense, to a topological space.
Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period
2011
Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Methods: Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300–500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room …
An ex-vivo model for transsynovial drug permeation of intraarticular injectables in naive and arthritic synovium
2021
Abstract Estimation of joint residence time of a drug is a key requirement for rational development of intraarticular therapeutics. There is a great need for a predictive model to reduce the high number of animal experiments in early stage development. Here, a Franz-cell based porcine ex-vivo permeation model is proposed, and transsynovial permeation of fluorescently-labeled dextrans in the range of potential drug candidates (10–150 kDa), as well as a small molecule (fluorescein sodium) and charged dextran derivates, have been determined. In addition, a lipopolysaccharide (LPS) -induced synovitis model was assessed for inflammatory biomarker levels and its effect on permeation of the solute…
Influence of surface processes and initial topography on lateral fold growth and fold linkage mode
2015
Elongation of randomly distributed fold segments and their potential linkage are important for hydrocarbon exploration because it can greatly influence the morphology of the reservoir and both migration and accumulation of hydrocarbons in antiformal traps. Here we study the effects of surface processes and the presence of a topographic slope on the different linkage modes that can occur, and how these parameters affect the required horizontal offset for perturbations to link. The proposed numerical model represents a sedimentary cover detached over a much weaker basal decollement layer. The upper surface is modified by mass redistribution, which is achieved by a combination of fluvial and h…
A multidisciplinary approach to the evaluation of the mechanism that triggered the Cerda landslide (Sicily, Italy).
2005
Abstract The present paper describes a multidisciplinary approach to the evaluation of a seismically triggered landslide that occurred in the Cerda area (Italy) on September 6, 2002, about 1 h after an earthquake took place in the south Tyrrhenian Sea. The study was focused on an analysis of the role of the seismic input in triggering the landslide, in view of the evidence that no other mass movement was recorded in the adjacent areas despite geological and geomorphological spatial homogeneity. The studied area is located on a slope of the western flank of the Fiume Imera Settentrionale (Northern Sicily), which is made up of clayey–arenitic rocks. The slope inclines gently but is not unifor…
Management of Alluvial Forests Included in Natura 2000 91E0* Habitat Type in Maramureş Mountains Nature Park
2015
Abstract The Natura 2000 habitat type 91E0* Alluvial forests of Alnus glutinosa and Fraxinus excelsior (Alno-Padion, Alnion incanae, Salicion albae) include three subtypes of forests. In the Maramureș Mountains Nature Park (MMNP) the alluvial forests are represented by Alnus incana forest situated on the banks of mountain rivers. Starting from 2007, 70% of the MMNP is also a Natura 2000 site of community interest. In the standard form for the site are listed 18 Natura 2000 habitat types, but that of alluvial forests 91E0* is not listed either due to an error or lack of available research data. Our study seeks to provide information regarding this high conservation value habitat such as: str…
Endothelin-1 modulates the expression of adhesion molecules on fibroblast-like synovial cells (FLS)
1996
Endothelin-1 is known to possess various biological properties. In the present study we have investigated the effects of Endothelin-1 (Et-1) on the expression of adhesion molecules ICAM-1, VCAM-1 and CD-44 by fibroblast-like synoviocytes. Cultured fibroblast-like synoviocytes were treated with Et-1 in the absence or presence of C1306, a specific endothelin-A-receptor antagonist. Cell surface expression of ICAM-1, VCAM-1 and CD-44 was determined by immunofluorescence studies, Cyto-ELISA and FACS-analysis. ICAM-1, VCAM-1 and CD-44 were constitutively expressed on cultured FLS. After incubation with Et-1 the expression of ICAM-1, VCAM-1 and CD-44 increased. The level of expression of adhesion …