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showing 10 items of 5786 documents
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
2015
International audience; Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T…
The hidden burden of severe asthma: from patient perspective to new opportunities for clinicians
2020
Severe asthma is an important topic in respiratory diseases, due to its high impact on morbidity and mortality as well as on health-care resources. The many challenges that still exist in the management of the most difficult-to-treat forms of the disease, and the acknowledgement of the existence of unexplored areas in the pathophysiological mechanisms and the therapeutic targets represent an opportunity to gather experts in the field with the immediate goals to summarize current understanding about the natural history of severe asthma and to identify gaps in knowledge and research opportunities, with the aim to contribute to improved medical care and health outcomes. This article is a conse…
Role of Biological Sex in the Cardiovascular-Gut Microbiome Axis
2022
There has been a recent, unprecedented interest in the role of gut microbiota in host health and disease. Technological advances have dramatically expanded our knowledge of the gut microbiome. Increasing evidence has indicated a strong link between gut microbiota and the development of cardiovascular diseases (CVD). In the present article, we discuss the contribution of gut microbiota in the development and progression of CVD. We further discuss how the gut microbiome may differ between the sexes and how it may be influenced by sex hormones. We put forward that regulation of microbial composition and function by sex might lead to sex-biased disease susceptibility, thereby offering a mechani…
Shakespeare, Art and Artifice: An Interview with Stuart Sillars
2019
Ahead of the publication of his forthcoming book, Shakespeare Seen: Image, Performance and Society (Cambridge, 2018), Stuart Sillars sat down for an interview with Perry McPartland. The discussion revisited a number of topics that Sillars has explored in his various publications on Shakespeare, including Shakespeare’s aesthetic strategies of transformation, the relationship his work takes to the visual, and the uses to which Shakespeare puts aesthetic artifice. The interview was conducted in two parts over a very nearly adequate Skype connection in the summer of 2018.
Sport participation and loneliness in adolescents: the mediating role of perceived social competence
2013
Published version of an article in the journal: Current Psychology. Also available from the publisher at: http://dx.doi.org/10.1007/s12144-013-9174-5 Young people perceive loneliness as a distressing emotional experience associated with sadness and boredom. Also, feelings of loneliness may be associated with psychosocial and emotional problems during adolescence. The aim of this study was to investigate whether perceived social competence mediated the cross-sectional relationship between sport participation and loneliness in young people when controlling for age, sex, shyness, and non-organized physical activity. This cross-sectional study consisted of 2,055 pupils (995 boys and 1,060 girls…
Learning to read for the first time as adult immigrants in Finland : Reviewing pertinent research of low-literate or non-literate learners’ literacy …
2018
Against the backdrop of increasing global humanitarian migration to highly literate countries and the resulting necessity and challenge to provide language and literacy education to non-literate or low-literate adult second language (L2) learners, this article calls for more research on a new population of late literacy learners, particularly in Finland. The article begins by outlining the pressing necessity for research on this special group of L2 learners who has traditionally been ignored by Second Language Acquisition (SLA) research. It will then go on to illuminate essential components of developing reading literacy, drawing on relevant previous research on pre-literates. Further, the …
Improving the Use of Simulation in Nursing Education: Protocol for a Realist Review
2020
BackgroundNursing education has evolved in line with societal needs, and simulation-based learning (SBL) is increasingly being used to bridge the gap between practice and education. Previous literature reviews have demonstrated the effectiveness of using SBL in nursing education. However, there is a need to explore how and why it works to expand the theoretical foundation of SBL.ObjectiveThis review aims to understand how, why, and in what circumstances the use of simulation affects learning as part of the bachelor’s program in nursing.MethodsA realist review will be conducted in accordance with the realist template for a systematic review. In particular, we will identify and explore the un…
Unethical but not illegal: Uncovering the persuasive messages leveraged by providers of the “real” online social impressions
2018
Due to the drastically elevated prominence of social networking sites (SNS), online social impressions such as views, comments, followers, subscribers, likes, and dislikes have become a valuable currency that translates to popularity, credibility, and even financial gains. Aside from machine-generated impressions, a growing industry known as crowdturfing utilizes human workers to provide “real” social impressions as-a-service. Although crowdturfing platforms are often seen as a clear example of deceptive conduct, they justify their business by leveraging well-crafted persuasive strategies and ethical appeals. Given the increasingly significant role of online impressions on shaping people’s …
Developing doctoral students' / researchers’ understanding of the journal peer-review process
2021
A growing body of knowledge has confirmed that the journal peer-review process is an integral part of the scientific publication process and provides demonstrable benefits to journal editors and authors. This study aims to develop doctoral students’ understanding of the journal peer-review process and highlight the most common errors and pitfalls reviewers identify in novice authors’ manuscripts, which could lead to rejection. A qualitative content analysis research method was used to analyse the primary data as experience collected from senior researchers, editors and associate editors. Among the major contributions of this study is an interactive diagram that provides an overview of the j…
“Congratulations, you’re on TV!”: Middle-space performances of live tweeters during the FIFA World Cup
2018
Social television has transformed the traditional role of the television viewers by providing ‘ordinary people’ access to the public stage. This article describes how public access to television affected the dialogues of Finnish tweeters on Twitter during the massive media event of the FIFA World Cup. Through the lens of digital conversation analysis, the study shows how the media publicity of tweets changed the direction of the interaction between tweeters and transformed their roles vis-à-vis the television show, making one of them into a ‘media flasher’ and the others viewers of his or her performance. The publicity was constructed as important through noticings, congratulations, and com…