Search results for "Virtual"
showing 10 items of 1485 documents
CHA on CDK2: a way to identify the best pharmacophore model for the virtual screening of new inhibitors
2018
Cyclin-dependent kinase-2 (CDK2) is a member of serine/threonine protein kinases family. It plays an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidences indicate that excessive expression of CDK2 should cause abnormal cell cycle regulation. Therefore, CDK2 has been considered a potential therapeutic target for cancer therapy. In this work, we used a modelling approach that incorporates flexibility based on extensive MD simulations of protein−ligand complexes into structure-based pharmacophore modeling and virtual screening to identify new CDK2 inhibitors. One-hundred and forty-nine CDK2-inhibit…
Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors
2013
Cyclooxygenase (COX) is a key enzyme in the biosynthetic pathway leading to the formation of prostaglandins, which are mediators of inflammation. It exists mainly in two isoforms COX-1 and COX-2. The conventional nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects because they inhibit both isoforms. Recent data demonstrate that the overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that the inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer. Agents that inhibit COX-2 while sparing COX-1 represent a new attractive therapeutic deve…
Application of Molecular Topology to the Prediction of the Reaction Yield and Anticancer Activity of Imidazole and Guanidine Derivatives
2013
In this study molecular topology based QSAR has been applied to predict the reaction yield and anticancer activity of 18 imidazole and guanidine derivatives. Four properties were evaluated, namely reaction yield, anti prostatic-cancer activity, anti breast-cancer activity and anti lung-cancer activity. The four models have been validated by both internal and cross validation, and also by randomness tests. The results obtained are in full agreement with the experimental results and confirm the precision, accuracy and robustness of the method followed. After carrying out a virtual screening upon such models, new imidazole and guanidine derivatives with potential anticancer activity are propos…
Le reti della buona morte
2017
Il saggio indaga le modalità di rappresentazione della morte a partire da siti internet dedicati e ai "gadget" in vendita on line per il corredo funerario
Impact of the knowledge society in the university and in scientific communication
2014
Over the last two decades, as a result of the introduction and intensive use of technologies for information and general knowledge, especially from the internet, the university is living in a process of complete transformation that affects it´s academic and organizational structures as well as the conception of educational methodology. The ICTs have demonstrated a need to establish coherent institutional strategies in their use and application, along with the possibility to expand the sphere of institutional action, in regards to general access to higher education. All of this shows an existing change from a model of education based on the transmission of knowledge, that was rather limited …
Mejoras basadas en heurísticas para la percepción de estímulos en simuladores de realidad virtual y realidad aumentada
2023
Los simuladores tratan de hacer creer a los usuarios que están viviendo una situación ajena a su realidad. Habitualmente los sentidos estimulados por los simuladores son el visual, el auditivo y el táctil, este último mediante la instalación de elementos con los que el usuario interactúa, como un volante, un joystick o incluso una cabina de control completa. Otros sentidos, como el olfato, la propiocepción o el vestibular (sentido del movimiento), suelen estimularse menos habitualmente. De todos los sentidos, la presente tesis doctoral se focaliza en el sentido del movimiento. La manera habitual de introducir estímulos de movimiento en usuarios de simuladores es mediante plataformas de movi…
A gearbox model for processing large volumes of data by using pipeline systems encapsulated into virtual containers
2020
Software pipelines enable organizations to chain applications for adding value to contents (e.g., confidentially, reliability, and integrity) before either sharing them with partners or sending them to the cloud. However, the pipeline components add overhead when processing large volumes of data, which can become critical in real-world scenarios. This paper presents a gearbox model for processing large volumes of data by using pipeline systems encapsulated into virtual containers. In this model, the gears represent applications, whereas gearboxes represent software pipelines. This model was implemented as a collaborative system that automatically performs Gear up (by using parallel patterns…
Designing a Low-Fat Food Packaging: Comparing Consumers’ Responses in Virtual and Physical Shopping Environments
2021
This paper aims to test to what extent emotional responses towards a low-fat product presented virtually converge with emotional responses toward this product when presented physically. Second, we want to probe if low-order emotions (physiological/unconscious responses) and high-order emotions (cognitive/conscious responses) converge to explain healthy product choices. To this end, 83 young participants were engaged in our experiment. Two packaging design variables were manipulated with the help of a real company (the color and the message), so that six different packages were created. Two different buying contexts were simulated: A virtual context and a physical context. Physiological resp…
The influence of virtual reality in e-commerce
2019
[EN] The development of virtual reality (VR), together with other technological innovations will shape the future of e-retailing. This research studies the effectiveness of different VR formats and devices in a virtual store environment, namely V-commerce. This study proposes and test a conceptual model that analyses the relations between sense of presence, brand recall and purchase intention, while also going deeper into their antecedents. Our findings suggest differences in purchase intention depending on VR format and device used. No differences are shown in sense of presence and affect by VR format and device. Our tested model suggests a dual route of influence of VR on consumers' purch…
Vers une instrumentalisation généralisée du lien communautaire en ligne : la montée en puissance du Community Management
2014
International audience; L’apparition et le développement du processus de socialisation en ligne se conçoit plus que jamais à l’intérieur de logiques marketing et marchandes : d’une part, le développement économique des réseaux sociaux se construit sur l’activité communicationnelle entre les usagers et crée de la valeur ; d’autre part, la puissance capitalistique des opérateurs du Web 2.0 permet de fournir aux usagers des plateformes d’échanges performantes, évolutives et conviviales qui assoient le développement du processus de socialisation lui-même (création et échanges de contenus, construction d’appartenances, constructions de solidarités et de réciprocités, etc.). Ainsi, c’est le déplo…