Search results for "Virtual"

Servizi bancari essenziali: il conto corrente

2022

The work proposes an analysis of the various tools that can be invoked to bridge some frictions of the credit system in areas where the banking "service" is characterized by essentiality, such as in the case of bank account. The inefficiency of the traditional code regulations emerges with particular evidence when the recourse to banking intermediation is imposed by specific rules functionality to public interests, as in case of imposed virtual currency payments. The incidence of the cost of the service, often not adequately remunerated by the price, can cause an indiscriminate selection of customers, permitted by contractual rules that authorize the end of the relationship without requirin…

Una chiesa scomparsa “dentro della nuova, assai più magnifica”. Progetti e ricostruzioni della cattedrale di Mdina tra Medioevo ed Età Moderna

2023

A corpus of drawings attributable to the seventeenth and eighteenth centuries, and preserved in the Diocesan archive of Mdina, allows us to better understand the reconstruction of the Cathedral of Malta after the earthquake of 1693, which damaged the medieval building. This had already been interested, a few years earlier, bu some works that had affected the presbytery area. The survey and project drawings, partly published but never studied in depth, offer valuable information on the medieval church and on the transformation process, on the relationship between the pre-existing buildings and the new projects. Starting from the available drawings, and with the support of documentary data an…

Social capital development of rural community based on social networking activities in Lithuania

2018

The scholar literature on simultaneous using of social capital explore knowledge and identity resources as well as actions and interactions benefiting the community through personal bonds of individuals; issues of common trust; and adapting the current understanding in new situations. In this article, we instead examine rural community influence on social capital building of adult person in a virtual community. A quantitative survey was done in 246 local rural communities in Lithuania which reflected their community activities on a virtual basis. From the data of 500 informants we found that rural community (human social network) members were also active in the virtual communities. Research…

Misura, Interpretazione, Racconto: il soffitto della Sala Magna nello Steri di Palermo

2008

Identification of Novel Anthracycline Resistance Genes and Their Inhibitors

2021

Differentially expressed genes have been previously identified by us in multidrug-resistant tumor cells mainly resistant to doxorubicin. In the present study, we exemplarily focused on some of these genes to investigate their causative relationship with drug resistance. HMOX1, NEIL2, and PRKCA were overexpressed by lentiviral-plasmid-based transfection of HEK293 cells. An in silico drug repurposing approach was applied using virtual screening and molecular docking of FDA-approved drugs to identify inhibitors of these new drug-resistant genes. Overexpression of the selected genes conferred resistance to doxorubicin and daunorubicin but not to vincristine, docetaxel, and cisplatin, indicating…

Towards Service-oriented 5G: Virtualizing the Networks for Everything-as-a-Service

2018

It is widely acknowledged that the forthcoming 5G architecture will be highly heterogeneous and deployed with a high degree of density. These changes over the current 4G bring many challenges on how to achieve an efficient operation from the network management perspective. In this article, we introduce a revolutionary vision of the future 5G wireless networks, in which the network is no longer limited by hardware or even software. Specifically, by the idea of virtualizing the wireless networks, which has recently gained increasing attention, we introduce the Everything-as-a-Service (XaaS) taxonomy to light the way towards designing the service-oriented wireless networks. The concepts, chall…

A Practical Perspective: The Effect of Ligand Conformers on the Negative Image-Based Screening.

2019

Negative image-based (NIB) screening is a rigid molecular docking methodology that can also be employed in docking rescoring. During the NIB screening, a negative image is generated based on the target protein’s ligand-binding cavity by inverting its shape and electrostatics. The resulting NIB model is a drug-like entity or pseudo-ligand that is compared directly against ligand 3D conformers, as is done with a template compound in the ligand-based screening. This cavity-based rigid docking has been demonstrated to work with genuine drug targets in both benchmark testing and drug candidate/lead discovery. Firstly, the study explores in-depth the applicability of different ligand 3D conformer…

The coffee-house: Upcycling spent coffee grounds for the production of green geopolymeric architectural energy-saving products

2023

This study investigates a possible alternative reuse of spent coffee grounds (SCG), the major residue of the brewing process, to manufacture green geopolymeric materials for innovative building applications in energy-saving construction, in line with the European Green Deal towards zero-energy building. Specimens were prepared by a combination of biomass fly ash from the Kraft paper-pulp process, as raw material (70 wt%), and SCG (up to 17.5 %), as filler. The high amount of reused bio-wastes makes the material fit the requirements for the Minimum Environmental Criteria (MEC) certification, in light of the Circular Economy (CE) approach. Sustainability is also boosted by the manufacturing p…

The mechanically-based approach to 3D non-local linear elasticity theory: Long-range central interactions

2010

Abstract This paper presents the generalization to a three-dimensional (3D) case of a mechanically-based approach to non-local elasticity theory, recently proposed by the authors in a one-dimensional (1D) case. The proposed model assumes that the equilibrium of a volume element is attained by contact forces between adjacent elements and by long-range forces exerted by non-adjacent elements. Specifically, the long-range forces are modelled as central body forces depending on the relative displacement between the centroids of the volume elements, measured along the line connecting the centroids. Further, the long-range forces are assumed to be proportional to a proper, material-dependent, dis…

Mechanically-based approach to non-local elasticity: Variational principles

2010

Abstract The mechanically-based approach to non-local elastic continuum, will be captured through variational calculus, based on the assumptions that non-adjacent elements of the solid may exchange central body forces, monotonically decreasing with their interdistance, depending on the relative displacement, and on the volume products. Such a mechanical model is investigated introducing primarily the dual state variables by means of the virtual work principle. The constitutive relations between dual variables are introduced defining a proper, convex, potential energy. It is proved that the solution of the elastic problem corresponds to a global minimum of the potential energy functional. Mo…