Search results for "Virtual"
showing 10 items of 1485 documents
An adaptive display to treat stress-related disorders: EMMA's World
2009
ABSTRACT Most of the virtual environments currently available in the field of psychological treatments were designed to solve a specific problem. Our research group has developed a versatile virtual reality system (an adaptive display) called ‘EMMA's world’, which can address a wide range of problems. It was designed to assist in clinical situations where a person has suffered a stressful experience, for example post-traumatic stress disorder, adjustment disorder, and pathological grief. To accomplish therapeutic goals, a series of emotional virtual elements are used and personalised so that they are meaningful to the user and contain the fundamental emotional elements that the person must …
EMMA: An Adaptive Display for Virtual Therapy
2007
Environments used up to now for therapeutic applications are invariable ones. Their contents can not be changed neither by the therapist nor by the patient. However, this is a technical issue that can be solved with current technology. In this paper, we describe a virtual environment that has been developed taking into account this factor. The main technical feature of the environment is that its aspect can be modified controlled by the therapist that conducts the clinical sessions depending on the emotions that the patient is feeling at each moment, and depending on the purpose of the clinical session. The environment has been applied for the treatment of post traumatic stress disorder, pa…
Virtual and Augmented Reality Applied to the Perception of the Sound and Visual Garden
2022
The COVID-19 situation has encouraged the creation of ICT-based learning environments. Difficulties in performing activities in a garden setting can be overcome by using Virtual Reality (VR) and Augmented Reality (AR). The aim of this research is to evaluate the usefulness of VR and AR as an educational resource through contextualised sensory experiences in the garden. Eighty-seven trainee teachers took part, and a mixed methodology was used, for the analysis of the sound and visual elements of the garden and for reflection on the usefulness of VR and AR. An interpretive and inferential analysis of the AR-based compositions was carried out and of the drawings of the garden created by the pa…
Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer
2021
To date, the virtual multidisciplinary tumor boards (vMTBs) are increasingly used to achieve high-quality treatment recommendations across health-care regions, which expands and develops the local MTB team to a regional or national expert network. This review describes the process of lung cancer-specific MTBs and the transition process from face-to-face tumor boards to virtual ones. The review also focuses on the project organization's description, advantages, and disadvantages. Semi-structured interviews identified five major themes for MTBs: current practice, attitudes, enablers, barriers, and benefits for the MTB. MTB teams exhibited positive responses to modeled data feedback. Virtualiz…
Virtual and arrow Temperley–Lieb algebras, Markov traces, and virtual link invariants
2021
Let [Formula: see text] be the algebra of Laurent polynomials in the variable [Formula: see text] and let [Formula: see text] be the algebra of Laurent polynomials in the variable [Formula: see text] and standard polynomials in the variables [Formula: see text] For [Formula: see text] we denote by [Formula: see text] the virtual braid group on [Formula: see text] strands. We define two towers of algebras [Formula: see text] and [Formula: see text] in terms of diagrams. For each [Formula: see text] we determine presentations for both, [Formula: see text] and [Formula: see text]. We determine sequences of homomorphisms [Formula: see text] and [Formula: see text], we determine Markov traces […
Varieties of representations of virtual knot groups in SL2(C)
2002
Abstract We study the local structure of the variety of representations of a virtual knot group in SL 2 ( C ) near an abelian representation ρ 0 . To such a representation is attached a complex number ω and there are three cases. If ω and ω −1 are not roots of the Alexander polynomial, there are only abelian representations around ρ 0 . If ω is a root and ω −1 is not, there are only reducible representations. If both ω and ω −1 are roots and certain homological conditions hold, there are irreducible representations.
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
2012
We present an integrated approach to identify and optimize a novel class of γ-secretase modulators (GSMs) with a unique pharmacological profile. Our strategy included (i) virtual screening through application of a recently developed protocol (PhAST), (ii) synthetic chemistry to discover structure–activity relationships, and (iii) detailed in vitro pharmacological characterization. GSMs are promising agents for treatment or prevention of Alzheimer’s disease. They modulate the γ-secretase product spectrum (i.e., amyloid-β (Aβ) peptides of different length) and induce a shift from toxic Aβ42 to shorter Aβ species such as Aβ38 with no or minimal effect on the overall rate of γ-secretase cleavag…
Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones
2014
Protozoan parasites have been one of the most significant public health problems for centuries and several human infections caused by them have massive global impact. Most of the current drugs used to treat these illnesses have been used for decades and have many limitations such as the emergence of drug resistance, severe side-effects, low-to-medium drug efficacy, administration routes, cost, etc. These drugs have been largely neglected as models for drug development because they are majorly used in countries with limited resources and as a consequence with scarce marketing possibilities. Nowadays, there is a pressing need to identify and develop new drug-based antiprotozoan therapies. In …
Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays
2006
QSAR (quantitative structure-activity relationship) studies of tyrosinase inhibitors employing Dragon descriptors and linear discriminant analysis (LDA) are presented here. A data set of 653 compounds, 245 with tyrosinase inhibitory activity and 408 having other clinical uses were used. The active data set was processed by k-means cluster analysis in order to design training and prediction series. Seven LDA-based QSAR models were obtained. The discriminant functions applied showed a globally good classification of 99.79% for the best model Class=-96.067+1.988 x 10(2)X0Av +9 1.907 BIC3 + 6.853 CIC1 in the training set. External validation processes to assess the robustness and predictive pow…
Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors
2019
[EN] The development and advancement of prostate cancer (PCa) into stage 4, where it metastasize, is a major problem mostly in elder males. The growth of PCa cells is stirred up by androgens and androgen receptor (AR). Therefore, therapeutic strategies such as blocking androgens synthesis and inhibiting AR binding have been explored in recent years. However, recently approved drugs (or in clinical phase) failed in improving the expected survival rates for this metastatic-castration resistant prostate cancer (mCRPC) patients. The selective CYP17A1 inhibition of 17,20-lyase route has emerged as a novel strategy. Such inhibition blocks the production of androgens everywhere they are found in t…