Search results for "Virus"
showing 10 items of 5024 documents
Habitual physical activity and heart rate variability in 12-year old children
2012
ABSTRACT Wennman, Heini 2012. Habitual physical activity and heart rate variability in 12-year old children. Department of Biology of Physical Activity, University of Jyväskylä, 92p. The study of heart rate variability (HRV) provides useful information about the function of the cardiac autonomic nervous system. The effects of many environmental factors on HRV are well known, but the associations between physical activity (PA) and HRV, especially in children, are less investigated. Higher HRV is related to health and many pathologic conditions are associated with reduced HRV. Exercise causes HRV to diminish, but improves HRV in long term. PA promotes many health related changes in energy met…
Development of baculovirus display strategies towards targeting to tumor vasculature
2006
Matilaisen väitöstutkimuksen tavoitteena oli kehittää bakulovirusta käytettäväksi geeniterapiaan syövän hoitoon. Bakulovirus on hyönteisvirus ja siten turvallisempi vaihtoehto kokeellisessa geeniterapiassa tällä hetkellä käytettäville patogeenisille viruksille tai niiden muunnelmille.Matilainen tutki myös virusten ja käytettyjen kohdennuspeptidien sisääntulomekanismeja ihmisen syöpäsoluihin. Tutkimuksessa löydettiin mahdollisesti bakuloviruksen uusi vaihtoehtoinen sisääntuloreitti. Virusten ja kohdennusmolekyylien reseptoreiden sisääntulomekanismien tutkimus ja tunteminen on edellytyksenä onnistuneiden geeninsiirtojen aikaansaamiselle ja täten myös onnistuneelle geeniterapialle.Matilainen k…
ICTV Virus Taxonomy Profile : Finnlakeviridae
2020
Finnlakeviridae is a family of icosahedral, internal membrane-containing bacterial viruses with circular, single-stranded DNA genomes. The family includes the genus, Finnlakevirus, with the species, Flavobacterium virus FLiP. Flavobacterium phage FLiP was isolated with its Gram-negative host bacterium from a boreal freshwater habitat in Central Finland in 2010. It is the first described single-stranded DNA virus with an internal membrane and shares minimal sequence similarity with other known viruses. The virion organization (pseudo T=21 dextro) and major capsid protein fold (double-β-barrel) resemble those of Pseudoalteromonas phage PM2 (family Corticoviridae), which has a double-stranded …
Recombinant nanocapsid for targeted theranostic delivery
2017
Developments in diagnostic and therapeutic delivery are trending towards molecular level targeting with nano-platforms. Targeted delivery reduces generalized distribution by localizing diagnostic and/or therapeutic (theranostic) molecules to an intended target site. The first section of this thesis proposes Hepatitis E Virus (HEV) nanocapsids as a vector to stabilize and target theranostic delivery. Derived from the capsid protein of HEV, a feco-orally transmitted virus, HEV-like particles self-assemble in to non-infectious, nanocapsids that can withstand harsh protease and pH conditions in the mucosal system. The flexible nanocapsid surface protrusion domain is amenable to substantial modi…
"Missed" Information: A Moral Failing that Erodes Efforts to Tackle the COVID-19 Pandemic.
2021
Single-cell analysis of population context advances RNAi screening at multiple levels
2012
Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…
Predictors of changing patterns of adherence to containment measures during the early stage of COVID-19 pandemic: an international longitudinal study
2023
Abstract Background Identifying common factors that affect public adherence to COVID-19 containment measures can directly inform the development of official public health communication strategies. The present international longitudinal study aimed to examine whether prosociality, together with other theoretically derived motivating factors (self-efficacy, perceived susceptibility and severity of COVID-19, perceived social support) predict the change in adherence to COVID-19 containment strategies. Method In wave 1 of data collection, adults from eight geographical regions completed online surveys beginning in April 2020, and wave 2 began in June and ended in September 2020. Hypothesized pre…
Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering an…
2021
To efficiently lower virus infectivity and combat virus epidemics or pandemics, it is important to discover broadly acting antivirals. Here, we investigated two naturally occurring polyphenols, Epigallocatechin gallate (EGCG) and Resveratrol (RES), and polyphenol-functionalized nanoparticles for their antiviral efficacy. Concentrations in the low micromolar range permanently inhibited the infectivity of high doses of enteroviruses (107 PFU/mL). Sucrose gradient separation of radiolabeled viruses, dynamic light scattering, transmission electron microscopic imaging and an in-house developed real-time fluorescence assay revealed that polyphenols prevented infection mainly through clustering of…
Valor predictivo de la carga viral de Citomegalovirus y Torquetenovirus en heces y plasma del desarrollo de enfermedad de injerto contra huésped inte…
2022
Uno de los retos clínicos más relevantes en los pacientes sometidos a trasplante alogénico de precursores hematopoyéticos (alo-TPH) es reducir el riesgo de enfermedad de injerto contra huésped (EICH). Otro de estos, es evitar la infección por Citomegalovirus (CMV) debido a su elevada morbilidad y mortalidad. En este contexto, se ha postulado una posible relación recíproca entre el riesgo de EICH y la infección por CMV, aunque existen datos contradictorios en la literatura a este respecto, especialmente al relacionar la presencia de CMV en heces, como predictor de EICH de tipo intestinal. Adicionalmente, el Torque Teno Virus (TTV) se encuentra actualmente bajo estudio debido a su íntima rela…
Torque teno virus como marcador subrogado de inmunocompetencia en el trasplante
2019
El torque teno virus (TTV), es un virus de pequeño tamaño de ADN de cadena sencilla, desnudo y capsulado perteneciente a la familia Anelloviridae con una prevalencia aproximada del 95% independiente del sexo y del estado socioeconómico y cuya carga plasmática está relacionada con la funcionalidad del sistema inmune y por tanto puede ser útil para evaluar el riesgo de eventos adversos relacionados con la inmunosupresión. El efecto del acondicionamiento sobre la ADNemia de TTV en pacientes sometidos a trasplante alogénico de precursores hematopoyéticos (alo-TPH) ocasiona un descenso de las cargas del virus que se ve acompañado por un descenso paralelo del recuento absoluto de linfocitos. Tras…