Search results for "Volt"
showing 10 items of 2187 documents
A Novel Histogram for Partial Discharge Signals in HV Insulating Systems
1986
A technique for relating measurable electrical quantities with energies dissipated inside a void in highly electrically stressed insulation is presented. It is based on measuring, for each apparent discharge level qe, the algebraic sum of the external energy pulses of all discharges having a value qe and occurring over some cycles of test voltage. Theoretical investigations show that the results of such external energy summations are equal to the energies dissipated in the void. A novel histogram is also suggested which relates the apparent discharge amplitudes with their respective energies in the void. Experimental tests were carried out under controlled conditions with samples of thermop…
Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: A “joint venture” alkaloid from arthropods and amphibians
2008
Abstract Certain amphibians provide themselves with a chemical defense by accumulating lipophilic alkaloids into skin glands from dietary arthropods. Examples of such alkaloids are pumiliotoxins (PTXs). In general, PTXs are known as positive modulators of voltage-gated sodium channels (VGSCs). Unlike other PTXs, PTX 251D does not share this characteristic. However, mice and insect studies showed that PTX 251D is highly toxic and to date the basis of its toxicity remains unknown. In this work, we searched for the possible target of PTX 251D . The toxin was therefore made synthetically and tested on four VGSCs (mammalian rNa v 1.2/β 1 , rNa v 1.4/β 1 , hNa v 1.5/β 1 and insect Para/tipE ) and…
Optimal Mass Transport on Metric Graphs
2015
We study an optimal mass transport problem between two equal masses on a metric graph where the cost is given by the distance in the graph. To solve this problem we find a Kantorovich potential as the limit of $p$-Laplacian--type problems in the graph where at the vertices we impose zero total flux boundary conditions. In addition, the approximation procedure allows us to find a transport density that encodes how much mass has to be transported through a given point in the graph, and also provides a simple formula of convex optimization for the total cost.
Polymorphism and solvates of flecainide base
2013
Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamically stable form at laboratory temperature while form IIIb is stable at higher temperatures. Flecainide form Ib absorbs water in its structure between layers and forms non-stoichiometric hydrate. Flecainide base binds with organic solvents and form monosolvates. Flecainide base form Ib crystallizes in orthorhombic crystals with lattice parameters a = 27.88 Å, b = 13.78 Å, c = 9.…
Methods for Transient Expression of Hetero-Oligomeric Ligand-Gated Ion Channels
2003
Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment.
2021
Abstract Astrocytes are key regulators of their surroundings by receiving and integrating stimuli from their local microenvironment, thereby regulating glial and neuronal homeostasis. Cumulating evidence supports a plethora of heterogenic astrocyte subpopulations that differ morphologically and in their expression patterns of receptors, transporters and ion channels, as well as in their functional specialisation. Astrocytic heterogeneity is especially relevant under pathological conditions. In experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS), morphologically distinct astrocytic subtypes were identified and could be linked to transcriptome changes dur…
Il "Candide" da Voltaire e Bernstein
2015
Il saggio ricostruisce la genesi del "Candide" di Leonard Bernstein, e la storia delle sue tante stesure e riprese: dal primo progetto teatrale del 1953-54 sino cosiddetta "Scottish Opera Version, curata da John Mauceri, del 1988. Il percorso drammaturgico dello spettacolo viene messo a confronto con le narrazioni del romanzo di Voltaire e nella seconda parte del saggio vengono affrontati anche gli aspetti musicali e compositivi dell'opera.
Why do Helvétius' writings matter? Rousseau's Notes sur De l'esprit
2016
International audience; De l’esprit was read and commented on by Rousseau, Diderot, and Voltaire, in 1758. So was De l’homme when it appeared posthumously in 1773. We will go into this series of books, marginalia, and refutations, to address the question: what exactly was widely discussed between the three authors during the 1750s? Is it ‘materialism’? Our first point is to interpret the potential distortions, re-workings or re-appropriations in Rousseau’s marginalia, known as Notes sur De l’esprit, especially here about the so-called theory of passive judgement. We will then see that there certainly is, in the discussion between Rousseau and Helvétius, a real opposition on the question of…
C'est la faute à Voltaire... Une imposture intellectuelle ?
2009
National audience