Search results for "Vorozole"

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Reinvestigation of the synthesis and evaluation of [N-methyl-11C]vorozole, a radiotracer targeting cytochrome P450 aromatase

2009

Abstract Introduction We reinvestigated the synthesis of [ N -methyl- 11 C]vorozole, a radiotracer for aromatase, and discovered the presence of an N -methyl isomer which was not removed in the original purification method. Herein we report the preparation and positron emission tomography (PET) studies of pure [ N -methyl- 11 C]vorozole. Methods Norvorozole was alkylated with [ 11 C]methyl iodide as previously described and also with unlabeled methyl iodide. A high-performance liquid chromatography (HPLC) method was developed to separate the regioisomers. Nuclear magnetic resonance (NMR) spectroscopy ( 13 C and 2D-nuclear Overhauser effect spectroscopy NMR) was used to identify and assign s…

Cancer ResearchMagnetic Resonance SpectroscopyTime FactorsAlkylationStereochemistryStereoisomerismNuclear Overhauser effectAlkylationHigh-performance liquid chromatographyArticlechemistry.chemical_compoundAromatasemedicineStructural isomerAnimalsRadiology Nuclear Medicine and imagingHydrocarbons IodinatedRadioactive TracersChromatography High Pressure LiquidChemistryBrainStereoisomerismNuclear magnetic resonance spectroscopyTriazolesPositron-Emission TomographyVorozoleMolecular MedicineFemalePapiomedicine.drugMethyl iodideNuclear Medicine and Biology

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