Search results for "WELL"
showing 10 items of 2241 documents
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
2013
Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional…
Genome-wide association scan of attention deficit hyperactivity disorder
2008
Contains fulltext : 70191.pdf (Publisher’s version ) (Closed access) Results of behavioral genetic and molecular genetic studies have converged to suggest that genes substantially contribute to the development of attention deficit/hyperactivity disorder (ADHD), a common disorder with an onset in childhood. Yet, despite numerous linkage and candidate gene studies, strongly consistent and replicable association has eluded detection. To search for ADHD susceptibility genes, we genotyped approximately 600,000 SNPs in 958 ADHD affected family trios. After cleaning the data, we analyzed 438,784 SNPs in 2,803 individuals comprising 909 complete trios using ADHD diagnosis as phenotype. We present t…
The growth of charged platelets.
2014
Growth models of charged nanoplatelets are investigated with Monte Carlo simulations and simple theory. In a first model, 2-dimensional simulations in the canonical ensemble are used to demonstrate that the growth of a single weakly charged platelet could be limited by its own internal repulsion. The short range attractive interaction in the crystal is modeled with a square well potential while the electrostatic interactions are described with a screened Coulomb potential. The qualitative behavior of this case can also be described by simply balancing the attractive crystal energy with the screened Coulomb repulsion between the crystal sites. This repulsion is a free energy term dominated b…
Canonical versus microcanonical analysis of first-order phase transitions
1998
Abstract I discuss the relation between canonical and microcanonical analyses of first-order phase transitions. In particular it is shown that the microcanonical Maxwell construction is equivalent to the equal-peak-height criterion often employed in canonical simulations. As a consequence the microcanonical finite-size estimators for the transition point, latent heat and interface tension are identical to standard estimators in the canonical ensemble. Special emphasis is placed on various ways for estimating interface tensions. The theoretical considerations are illustrated with numerical data for the two-dimensional 10-state Potts model.
Algunas reflexiones acerca de la stjue de 9 de julio de 2020 sobre los pactos novatorios en materia de cláusulas suelo
2021
The Sentence of the Court of Justice of the European Union of July 9, 2020 comes to answer the five questions that, in its preliminary question, the Court of First Instance and Instruction No. 3 of Teruel asks about the validity of the new agreements in the context of the floor clauses, establishing jurisprudential doctrine on this matter about which our Supreme Court had previously ruled in its Judgments of October 16, 2017, in the sense of considering the agreed floor clause null as a consequence of the novation agreement and, subsequently, those of April 11, 2018 and September 13, 2018 in the opposite direction, declaring that the novation agreement was valid. It is a long-awaited and in…
List of cave‐dwelling (hypogeal) species and subspecies considered as troglobites and stygobias of the Iberian Peninsula and the Balearic Islands
2022
12 p.
Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteins
1986
Conventional staining methods alone are often insufficient to make accurate histodiagnosis of malignant tumors. However, additional information about the cell type and the state of differentiation of tumor cells can be provided by several molecular markers. To be relevant diagnostically, these markers must be conservative, i.e. expressed not only in well differentiated tumors but also in poorly differentiated tumors and in metastases. These criteria are fulfilled by certain components of the cytoskeleton, notably the proteins forming the intermediate-sized filaments (IFs) and the desmosomal plaque proteins.
The emergence of Vibrio pathogens in Europe : ecology, evolution, and pathogenesis (Paris, 11-12th March 2015)
2015
Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring during episodes of unusually warm weather. Similar patterns were also observed in Vibrio-associated diseases affecting marine organisms such as fish, bivalves and corals. Basic knowledge is still lacking on the ecology and evolutionary biology of these bacteria as well as on their virulence mechanisms. Current limitations in experimental systems to study infection and the lack of diagnostic tools still prevent a better understanding of Vibrio…
Effect of blastfurnace slag addition to Portland cement for cationic exchange resins encapsulation
2013
In the nuclear industry, cement-based materials are extensively used to encapsulate spent ion exchange resins (IERs) before their final disposal in a repository. It is well known that the cement has to be carefully selected to prevent any deleterious expansion of the solidified waste form, but the reasons for this possible expansion are not clearly established. This work aims at filling the gap. The swelling pressure of IERs is first investigated as a function of ions exchange and ionic strength. It is shown that pressures of a few tenths of MPa can be produced by decreases in the ionic strength of the bulk solution, or by ion exchanges (2Na + instead of Ca 2+ , Na + instead of K + ). Then,…
Trophic ecology of the swimming crab Polybius henslowii Leach, 1820 in Galician and Cantabrian Seas: Influences of natural variability and the Presti…
2008
9 pages, 9 figures, 2 tables.-- Printed version published Nov 15, 2008.