Search results for "WELL"

Eustress and distress climates in teams: Patterns and outcomes.

2015

Monte Carlo Simulation of a Modified Chi Distribution with Unequal Variances in the Generating Gaussians. A Discrete Methodology to Study Collective …

2020

The Chi distribution is a continuous probability distribution of a random variable obtained from the positive square root of the sum of k squared variables, each coming from a standard Normal distribution (mean = 0 and variance = 1). The variable k indicates the degrees of freedom. The usual expression for the Chi distribution can be generalised to include a parameter which is the variance (which can take any value) of the generating Gaussians. For instance, for k = 3, we have the case of the Maxwell-Boltzmann (MB) distribution of the particle velocities in the Ideal Gas model of Physics. In this work, we analyse the case of unequal variances in the generating Gaussians whose distribution w…

Power struggle, submission and partnership: Agency constructions of mothers of children with ADHD diagnosis in their narrated school involvement

2014

The contemporary education paradigm highlights the interdependency of home and school expertise. This discourse analysis study examines the narrated agentive possibilities of 18 Finnish mothers of children diagnosed with ADHD to influence and be involved in their child's schooling. Mothers' strong involvement endeavor is premised on their expertise concerning ADHD, distrust of teachers' adequate knowledge of and attitude towards their child, and anxiety for their child's wellbeing. However, our analysis reveals a gap between the mothers' narrated potential agency to fight for her child's well-being and their actual capability to be involved as intended, due to unequal institutional power re…

A Life Cycle Model of XML Documents

2014

Electronic documents produced in business processes are valuable information resources for organizations. In many cases they have to be accessible long after the life of the business processes or information systems in connection with which they were created. To improve the management and preservation of documents, organizations are deploying Extensible Markup Language (XML) as a standardized format for documents. The goal of this paper is to increase understanding of XML document management and provide a framework to enable the analysis and description of the management of XML documents throughout their life. We followed the design science approach. We introduce a document life cycle model…

Aspects on XML Document Content Reuse in Organizaotins

2007

Designing the reuse of information residing in documents is more complex than for information in databases. Document content is designed for humans and organized with regard to communicational purposes for organizational work. In addition, content organization within documents is affected by the requirements of multichannel publishing and layout design for content presentation. Efficient content reuse in organizational documents requires that the ways the content is created and stored within and across documents and other content resources, such as databases, should be identified. XML provides technological means for document content reuse. The designers of XML document production need to b…

XML document-grammar comparison: related problems and applications

2011

10.2478/s13537-011-0005-1; International audience; XML document comparison is becoming an ever more popular research issue due to the increasingly abundant use of XML. Likewise, a growing interest fosters the development of XML grammar matching and comparison, due to the proliferation of heterogeneous XML data sources, particularly on the Web. Nonetheless, the process of comparing XML documents with XML grammars, i.e., XML document and grammar similarity evaluation, has not yet received the attention it deserves. In this paper, we provide an overview on existing research related to XML document/grammar comparison, presenting the background and discussing the various techniques related to th…

Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.

2017

Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but has not been specifically assessed so far. Here, we evaluated ARAF prevalence in azole-naïve COPD patients and their homes, and assessed whether CYP51A mutations were similar in clinical and environmental reservoirs. Sixty respiratory samples from 41 COPD patients with acute exacerbation and environmental samples from 36 of these patient's homes were prospectively collected. A. fumigatus was detected in respiratory samples from 11 of 41 patients (27%) and in 15 of 36 domiciles (42%). Cyp51A sequencing and selection on itraconazole medium of clinical (n = 68) and e…

Aloin delivery on buccal mucosa: ex vivo studies and design of a new locoregional dosing system

2014

Context: Chemoprevention of potential malignant disorders or cancerous lesions that affect oral mucosae requires extended duration of treatment. Locoregional delivery of natural products could represent a promising strategy for this purpose. Objective: To investigate the aptitude of aloin to permeate through, or accumulate in, the buccal mucosa and to develop a new prolonged oro-mucosal drug delivery system. Materials and Methods: Permeation/accumulation of aloin from Curacao Aloe (containing 50% barbaloin) was evaluated ex vivo, using porcine buccal mucosa as the most useful model to simulate human epithelium. Oro-mucosal matrix tablets were prepared by dispersing aloin (10% w/w) in Eudrag…

Inkjet printing methodologies for drug screening

2010

We show for the first time a contactless, low-cost, and rapid drug screening methodology by employing inkjet printing for molecular dispensing in a microarray format. Picoliter drops containing a model substrate (D-glucose)/ inhibitor (D-glucal) couple were accurately dispensed on a single layer consisting of the enzymatic target (glucose oxidase) covalently linked to a functionalized silicon oxide support. A simple colorimetric detection method allowed one to prove the screening capability of the microarray with the possibility to assay with high reproducibility at the single spot level. Measurements of the optical signal as a function of concentration and of time verified the occurrence a…

Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers

2017

In this work a new copolymer of inulin (INU) derivatized with ethylendiamine (EDA) and retinoic acid (RA), named INU-EDA-RA, was synthetized, characterized and employed to produce micelles as carriers for topical administration of corticosteroids for the potential treatment of diseases of posterior eye segment. Spectroscopic analysis confirmed a molar derivatization degree of 11.30 and 4.30% in EDA and RA, respectively. INU-EDA-RA micelles are capable of strong mucoadhesive interactions which result time-independent and stable over time but concentration depending. Moreover micelles are able to encapsulate efficiently from 3 to 13% (w/w) of lipophilic drugs, as dexamethasone, triamcinolone …