Search results for "WES"

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese

2014

PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each individual locus showed tendencies similar to determined previously in HapMap populations. Main differences concern Taiwanese and include presence of rs2277460 rare allele A not found before in Asians and absence of rs2295827 rare alleles homozygotes TT observed in all other human populations. Observed patterns of SNPs and haplotype diversity were compatible with expectation of neutral model of evolution. Linkage disequilibrium between the rs2295826 and rs2295827 was detected to be c…

High sensitivity of northern pike larvae to UV-B but no UV-photoinduced toxicity of retene

2003

In order to investigate whether increased UV-B radiation is a risk factor, a series of acute laboratory experiments was conducted with larval stages of the northern pike (Esox lucius L.), hatching in Nordic waters in May. Further, a comparative investigation on the acute phototoxicity of retene (7-isopropyl-1-methylphenanthrene), a PAH compound recently revealed to posses UV-B-induced phototoxicity in larval coregonids, was conducted with pike larvae. In semi-static experiment, larvae were pre-exposed to retene (3, 9, 30 and 82 microg/g), with relevant controls, for 24 h and then irradiated for 3 h once a day (two consecutive days) with three UV-B doses (CIE-weighted 1.0, 1.8 or 2.7 kJ/m2 p…

Heavy metal ion induction of adhesion molecules and cytokines in human endothelial cells: the role of NF-kappaB, I kappaB-alpha and AP-1.

1997

We analyzed the influence of heavy-metal ions on human umbilical vein endothelial cells (HUVEC) in comparison to proinflammatory cytokines (TNF-alpha, IL-1beta) and lipopolysaccharide (LPS). Adhesion molecule and cytokine expressions are upregulated by heavy-metal exposure. Expression of E-selectin on the cell surface was strongly induced by 1-mM concentrations of NiCl2 and CoCl2, whereas ZnCl2 and CrCl3 had no influence. Furthermore, it is shown that NiCl2 induces mRNA expression of E-selectin, intercellular adhesion molecule-1, IL-6 and IL-8 in a 1-mM concentration. The transcription factor NF-kappaB is known to be involved in the regulation of adhesion molecule expression in endothelial …

Conflict management in the international context : analyzing the role of the United Nations in the Western Sahara conflict

2017

The United Nations is the most productive international organization in resolving international world conflicts. The UN uses different techniques and approaches to resolve international conflicts, including mediation. This study analyzes the process of mediation and international conflict management from the point of view of UN efforts in the Western Sahara conflict, which has been ongoing since 1975. This study specifically focuses on the UN’s role in resolving intercultural conflict in Western Sahara and the concrete steps it has taken, such as implementation of the cease-fire, the Settlement Plan and establishing the Mission for an independence referendum in Western Sahara (MINURSO). It …

3'-Untranslated regions of oxidative phosphorylation mRNAs function in vivo, as enhancers of translation

2000

Recent findings have indicated that the 3´-untranslated region (3´-UTR) of the mRNA encoding the β-catalytic subunit of the mitochondrial H+-ATP synthase has an in vitro translation-enhancing activity (TEA) [Izquierdo and Cuezva, Mol. Cell. Biol. (1997) 17, 5255–5268; Izquierdo and Cuezva, Biochem. J. (2000) 346, 849–855]. In the present work, we have expressed chimaeric plasmids that encode mRNA variants of green fluorescent protein in normal rat kidney and liver clone 9 cells to determine whether the 3´-UTRs of nuclear-encoded mRNAs involved in the biogenesis of mitochondria have an intrinsic TEA. TEA is found in the 3´-UTR of the mRNAs encoding the α- and β-subunits of the rat H+-ATP syn…

New data on the Upper Triassic reefs of Western Sicily: stratigraphic constraints for the paleogeographic reconstruction of the Sicanian and Trapanes…

2005

Movement patterns of temperate wrasses (Labridae) within a small marine protected area

2021

The movement patterns of three commercially important wrasse (Labridae) species inside a small marine protected area (~ 0.15 km2 ) on the west coast of Norway were analysed over a period of 21 months. The mean distance between capture and recapture locations varied between 10 and 187 m, and was species and season specific. The extent of movement was not related to body size or sex. These results imply that a network of small strategically located marine protected areas can be used as management tools to protect wrasses from size- and sex-selective fishing mortality.

International Vocational Education and Training Research: An Introduction to the Special Issue

2021

The seven articles in this special issue represent a wide range of international comparative and review studies by international research teams from China, Germany, India, Russia, Switzerland and Mexico. The presented projects are part of the national program "Research on the Internationalisation of Vocational Education and Training", funded by the German Federal Ministry of Education and Research (BMBF). An adapted version of Urie Bronfenbrenner���s ecological systems theory forms the conceptual framework of the special issue. The four system levels (micro, meso, exo and macro) are addressed by one article each. The article on the microsystem level focuses on the intended and implemented c…

Historical preconditions for the development of “the right to a personal identity” in Western philosophy

2019

Any discussion on a person’s right to identity ought to start with a study of the content of a person’s identity. While ascertaining the essence of a person’s identity, the author was inclined to think that the development of a personal identity as a permanent concept was promoted by the genesis of the human dignity, individuality, autonomy and personality of a person. It is human dignity, the manifestation of which, inter alia, is to be found in the person’s identity, which forms the basis of its legal protection, transforming the identity of a person into legal value and, accordingly, creating the right of a person to identity. Thus the article provides a legally philosophical insight int…

Towards World Philosophy and a World History of Philosophy—Karl Jaspers: His Work, Calling, and Legacy

2011

Professor Wisser’s address to students during the Summer Semester of 1995 at the University of Mainz (Germany) regarding the contributions of Karl Jaspers on world philosophy, a history of world philosophy, and the value of his thought for philosophizing in general. Discussion of the semantics of seeing, hearing, and learning and what Jaspers has to offer as regards the continuous project of Bildung as contrast to other major figures in the history of Western philosophy and theology.