Search results for "WES"

Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages

2009

Objective— Cholesteryl ester transfer protein (CETP) is a target gene for the liver X receptor (LXR). The aim of this study was to further explore this regulation in the monocyte-macrophage lineage and its modulation by lipid loading and inflammation, which are key steps in the process of atherogenesis. Methods and Results— Exposure of bone marrow–derived macrophages from human CETP transgenic mice to the T0901317 LXR agonist increased CETP, PLTP, and ABCA1 mRNA levels. T0901317 also markedly increased CETP mRNA levels and CETP production in human differentiated macrophages, whereas it had no effect on CETP expression in human peripheral blood monocytes. In inflammatory mouse and human mac…

Harnessing Big Data for Communicable Tropical and Sub-Tropical Disorders: Implications From a Systematic Review of the Literature

2018

aim: According to the World Health Organization (WHO), communicable tropical and sub-tropical diseases occur solely, or mainly in the tropics, thriving in hot, and humid conditions. Some of these disorders termed as neglected tropical diseases are par- ticularly overlooked. Communicable tropical/sub-tropical diseases represent a diverse group of communicable disorders occurring in 149 countries, favored by tropical and sub-tropical conditions, affecting more than one billion people and imposing a dramatic societal and economic burden. methods: A systematic review of the extant scholarly literature was carried out, searching in PubMed/MEDLINE and Scopus. The search string used included prope…

The Impact of Artificial Intelligence on Traditional Chinese Medicine

2021

Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. Currently, artificial intelligence (AI) is rapidly expanding in many fields including TCM. AI will significantly improve the reliability and accuracy of diagnostics, thus increasing the use of effective therapeutic methods for patients. This systematic review provides an updated overview on the major breakthroughs in the field of AI-assisted TCM four diagnostic methods, syndrome differentiation, and treatment. AI-assisted TCM diagnosis is mainly based on digital data collected by modern electronic instruments, which makes TCM diagnosis more quantitative, objective, and standardized. As a result, th…

Prejudice Towards Muslims: A Study among Young People in the North-West Region of Cameroon

2020

Muslims and Christians in Cameroon have coexisted for decades within a shared context, but there are no studies that seek to understand the nature of Christian–Muslim intergroup relations within th...

Reflexive Modernization and the Disembedding of Jūdō from 1946 to the 2000 Sydney Olympics

2004

This article considers some of the sociologically significant changes to jūdō in its process of transformation from a Budō based martial art into a modern competitive spectator sport. Taking the period of time from 1946 until the Sydney Olympics, an examination is undertaken using Giddens’s notion of reflexive modernization in which key aspects of the original jūdō are disembedded or ‘lifted out’ of the practice. They are then re-embedded with western structures, practices and meanings. Central themes to emerge from this analysis are the social forces of internationalization, institutionalization and commodification of jūdō over this period, each of which contributes to a reflexive moderni…

Modeling Metaphysics: The Rise of Simulation and the Reversal of Platonism

2019

Philosophical reflection on and around Modeling and Simulation (M&S) is often focused on the ethical and epistemological implications of empirical findings or innovative methods within the field. In this paper I highlight some of the metaphysical implications of developments within M&S. I argue that the rise of simulation within and across scientific disciplines is accelerating the reversal of Platonism, whose emphasis on transcendence and reliance on hierarchical, static categories has dominated western philosophy for over two millennia. The success of M&S methodologies opens up new conceptual space for articulating a metaphysics of immanence that may provide a more adequate basis for unde…

Carbon isotope stratigraphy, magnetostratigraphy, and 40Ar/39Ar age of the Cretaceous South Atlantic coast, Namibe Basin, Angola

2014

This publication results from Projecto PaleoAngola, an international cooperative research effort among the contributing authors and their institutions, funded by the National Geographic Society, the Petroleum Research Fund of the American Chemical Society, Sonangol E.P., Esso Angola, Fundacao Vida of Angola, LS Films, Maersk, Damco, Safmarine, ISEM at SMU, The Royal Dutch Embassy in Luanda, TAP Airlines, Royal Dutch Airlines, The Saurus Institute, and the Perot Museum of Nature and Science. JS was additionally funded by Yale University and the Alfred Kordelin Foundation. We dedicate this contribution to the late Kalunga Lima, our friend and colleague in Projecto PaleoAngola. We thank Margar…

2019

Ingested soil is a major vector of organic contaminants from environment to free-ranged animals, particularly for grazing herbivores. Therefore, a better understanding of processes driving soil intake may provide new insights to limit animal exposure to contaminants and ensure safety of animal products. To maintain the supply service of livestock farming activities in contaminated areas, it is necessary to design adapted farming practices aiming at controlling the risk for human health. This study was conducted in the French West Indies, where chlordecone, an organochlorine insecticide previously used to protect banana plantation against the black weevil and banned since 1993, has polluted …

Errors and uncertainties introduced by a regional climate model in climate impact assessments: example of crop yield simulations in West Africa

2015

16 pages; International audience; The challenge of estimating the potential impacts of climate change has led to an increasing use of dynamical downscaling to produce fine spatial-scale climate projections for impact assessments. In this work, we analyze if and to what extent the bias in the simulated crop yield can be reduced by using the Weather Research and Forecasting (WRF) regional climate model to downscale ERA-Interim (European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis) rainfall and radiation data. Then, we evaluate the uncertainties resulting from both the choice of the physical parameterizations of the WRF model and its internal variability. Impact assessments w…

Parasite fauna and community structure of bathydemersal fishes: Notacanthus bonaparte (Osteichthyes), Etmopterus spinax and Deania profundorum (Chond…

2017

Resumen El mar profundo es el mayor bioma de la tierra y el menos estudiado (Ramirez-Llodra et al. 2010). Si bien inicialmente el mar profundo se consideró como un ambiente muy estable con variaciones muy leves por debajo de la termoclina permanente, los estudios realizados en las últimas décadas indican que el mar profundo es un ambiente más dinámico de lo que se pensaba (Gage 2003, Ramirez-Llodra et al. 2010). La variabilidad natural de los procesos que tiene lugar en los hábitats del mar profundo tiene su origen en diferentes factores entre los que se encuentran las corrientes horizontales de masas de agua de grandes dimensiones dirigidas por las corrientes circunglobales, las cuales pue…