Search results for "WES"
showing 10 items of 1585 documents
Aging Negatively Affects Estrogens-Mediated Effects on Nitric Oxide Bioavailability by Shifting ERα/ERβ Balance in Female Mice
2011
AIMS: Aging is among the major causes for the lack of cardiovascular protection by estrogen (E2) during postmenopause. Our study aims to determine the mechanisms whereby aging changes E2 effects on nitric oxide (NO) production in a mouse model of accelerated senescence (SAM). METHODS AND RESULTS: Although we found no differences on NO production in females SAM prone (SAMP, aged) compared to SAM resistant (SAMR, young), by either DAF-2 fluorescence or plasmatic nitrite/nitrate (NO2/NO3), in both cases, E2 treatment increased NO production in SAMR but had no effect in SAMP. Those results are in agreement with changes of eNOS protein and gene expression. E2 up-regulated eNOS expression in SAMR…
Impairment of intracellular antiviral defense with age: age-dependent changes in expression of interferon-induced and double-stranded RNA-activated 2…
1995
The 2',5'-oligoadenylate (2-5A) system is involved in the defense of mammalian cells against virus infection. In a previous study [25], we demonstrated that the activities of the enzymes which synthesize and degrade 2-5A [2-5A synthetase (2-5OAS) and 2',3'-exoribonuclease] and of the enzyme that is activated by 2-5A (ribonuclease L) change during aging and development in different tissues of rat. The age-dependent decrease in 2-5OAS activity and increase in 2-5A nuclease activity results in a decrease in the cellular 2-5A content, suggesting that the efficiency of the antiviral 2-5A system is impaired in aged rats. Here we determined the age-dependent changes in the level of mRNA coding for…
Endothelin Antagonism: Effects of FP Receptor Agonists Prostaglandin F2αand Fluprostenol on Trabecular Meshwork Contractility
2006
Purpose This study analyzes additional mechanisms behind the ocular hypotensive effect of prostaglandin F (PGF) receptor (FP receptor) agonists PGF2alpha and fluprostenol (fluprostenol-isopropyl ester [travoprost]), which reduce intraocular pressure (IOP) in patients with glaucoma probably by enhancing uveoscleral flow. The trabecular meshwork (TM) is actively involved in IOP regulation through contractile mechanisms. Contractility of TM is induced by endothelin (ET)-1, a possible pathogenic factor in glaucoma. The involvement of FP receptor agonists in the ET-1 effects on TM function was studied. Methods The effects of FP receptor agonists on contractility of bovine TM (BTM) were investiga…
Tiburones de aguas profundas en el Mioceno medio de Alicante: implicaciones para la recuperación de los ecosistemas abisales mediterráneos después de…
2017
El estudio de la localidad clásica de El Chorrillo del Mioceno Medio (Serravaliense) en la Provincia de Alicante, ha permitido la recuperación de una interesante asociación de microrestos de tiburones caracterizada por al menos siete taxones (Deania calcea, ¿Isistius triangulus, ¿Squaliolus cf. schaubi, ¿Paraetmopterus sp., Pristiophorus sp., Scyliorhinus sp. y un Squaliforme indeterminado) pertenecientes a tres órdenes diferentes (Squaliformes, Pristiophoriformes y Carcharhiniformes). Asociados a estos microrestos se han identificado también macrodientes pertenecientes a Cosmopolitodus hastalis, Isurus sp., Hemipristis serra, Odontaspis sp., Carcharhinus spp. y ¿Otodus (Megaselachus) megal…
Wesley Clair Mitchell and the “Illiberal Reformers”: A Documentary Note
2021
In this note we inquire whether Mitchell as a reformer ever expressed concern over the biological quality of individuals and whether he did somehow share the Progressive Era faith in eugenics as an instrument for improving American society’s health, welfare, and morals. This is an aspect of Mitchell’s thought that has received scant attention in the literature and that projects him into the current debate on progressivism.
First record of the enigmatic coleoid genus Longibelus from Sakhalin (Far East Russia): a contribution to our understanding of Cretaceous coleoid hab…
2021
AbstractA newly collected specimen of the enigmatic coleoid genus Longibelus is recorded from lower Turonian strata along the River Shadrinka in Sakhalin (Russian Far East). To date, this is the first record of Late Cretaceous coleoid cephalopods from the island and, in fact, from the entire Pacific coast of the Russian Federation. Lithological characteristics, coupled with published geochemical analyses (δ13C and Corg content), suggest the habitat of this coleoid taxon to have been the middle to outer (i.e. distal) shelf. Its provenance from the stratigraphical level that is known as the Scaphites Event, characterised by a mass occurrence of Scaphites and Yesoites, may be indicative of occ…
The earliest tupilakosaurid amphibian with diplospondylous vertebrae from the Late Permian of southern France
2007
5 pages; International audience; A well-preserved vertebral column from the Late Permian of Southern France (Lopingian, La Lieude Formation, Lodève Basin) is described. It is composed of diplospondylous vertebrae and is most comparable with the temnospondyl Tupilakosaurus previously known from the Early Triassic of Greenland and Russia. This new specimen therefore represents the earliest occurrence of a diplospondylous tupilakosaur, and extends the geographic range of the group to Western Europe. It is an aquatic temnospondyl that used the anguilliform undulatory mode of swimming.
The submerged syntax between Late Antiquity and the Modern Age. Sources, models, and interpretative strategies
2021
The present volume contains selected papers from the international conference on “The submerged syntax between Late Antiquity and the Modern Age. Sources, models, and interpretative strategies”, that took place in Palermo, 28-29 November 2019, hosted by the Department of Humanities at the University of Palermo. The conference was organized under the umbrella of a project of national relevance funded by the Italian Ministry of Education, University and Research, named “Parts of speech meet rhetorics: searching for syntax in the continuity between the Middle Ages and the Modern Age” (PRIN 20172F2FEZ, March 2017).
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development
2014
Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essential in the embryo proper. Loss of LRP1 leads to lethal vascular defects with lack of proper investment with mural cells of both large and small vessels. We further demonstrate that LRP1 modulates Gi-dependent sphingosine-1-phosphate (S1P) signaling and integrates S1P and PDGF-BB signaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain. Loss of LRP1 leads to a lack of S1P-dependent inhibition of RAC1 and loss of constraint of PDGF-BB-induced cell migra…
The influence of temperature on growth and proximate body composition of under yearling Lake Inari arctic char (Salvelinus alpinus (L.))
1997
The growth of underyearling Lake Inari arctic char was studied in groups of fish held at 5.9, 8.7, 12.1, 15.1 and 18.0 °C for 31 days. Growth rate increased with increasing water temperature, reached a peak at 15.1 °C, and then declined. The temperature influence on relative growth was expressed as a non-linear function. There were differences in body composition between fish reared at different temperatures: percentage water being highest at the lowest temperature, whereas energy content was highest in the fish held at the three highest temperatures. The body wet weight explained most of the variance in water content and it is suggested that this may also apply to other body constituents.