Search results for "WES"
showing 10 items of 1585 documents
Redox Proteomics of the Inflammatory Secretome Identifies a Common Set of Redoxins and Other Glutathionylated Proteins Released in Inflammation, Infl…
2015
Protein cysteines can form transient disulfides with glutathione (GSH), resulting in the production of glutathionylated proteins, and this process is regarded as a mechanism by which the redox state of the cell can regulate protein function. Most studies on redox regulation of immunity have focused on intracellular proteins. In this study we have used redox proteomics to identify those proteins released in glutathionylated form by macrophages stimulated with lipopolysaccharide (LPS) after pre-loading the cells with biotinylated GSH. Of the several proteins identified in the redox secretome, we have selected a number for validation. Proteomic analysis indicated that LPS stimulated the releas…
Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene
2001
22 pages, 7 figures, 1 table.
The Ancient Commentators of Plato and Aristotle
2009
In late antiquity the works of Plato and Aristotle were subject to intense study, which eventually led to the development of a new literary form, the philosophical commentary. Until recently these commentaries were understood chiefly as sources of information for the masters, Plato and Aristotle, they commented upon. However, in recent years, it has become increasingly acknowledged that the commentators themselves - Aspasius, Alexander, Themistius, Porphyry, Proclus, Philoponus, Simplicius and others - even though they worked in the Platonist-Aristotelian framework, contributed to this tradition in original, innovative and significant ways such that their commentaries are philosophically im…
The Triumphs? Golden Age : a comparison between three European translations of Ilicino?s Commentary.
2020
During the last part of the fifteenth and the first decades of the sixteenth centuries, the dissemination of Petrarch’s Trionfi – the so-called ‘second wave’ of Petrarchism – was characterized by the extraordinary editorial success, in Italy as well as in the rest of Western Europe, of Bernardo Ilicino’s Commento on the Trionfi. By promoting an erudite, encyclopedic, and moralizing reading of Petrarch’s poem, Ilicino’s commentary effectively became a lens through which generations of European readers approached the text. Nonetheless, the dissemination of the commentary proved not to be immune from the influence of sixteenth-century lyrical Petrarchism, which started developing almost at the…
On the Origin of Metaphors
2015
In this article I study the genesis of metaphors from an evolutionary perspective. Analyzing 414 cartoons published after the death of the cartoonists of the French satirical magazine Charlie Hebdo, I propose a metaphoric founder effect with the metaphors “PENCIL IS A WEAPON,” “PENCIL IS A CARTOONIST,” and “PENCIL IS FREEDOM,” and a subsequent metaphor drift that creates many related metaphors. Additionally, the success of these metaphors turns the pencil meme into a very efficient and fast-spreading item representing not only the work of cartoonists, but also the fundamental values of Western culture, such as freedom of expression.
Talis hominibus fuit oratio qualis vita. Nietzsche y la narración de sí
2015
Ecce Homo certainly is an unconventional autobiography. Both its structure and its contents are in fact quite different from that traditionally adopted. First, in Ecce Homo life and literary production basically coincide; second, in that book Nietzsche deals with an “I” which is not the traditional “subject” of Western philosophy. In this paper I shall argue that in Ecce Homo Nietzsche tries to develop a new kind of subjectivity. In particular, Nietzsche rejects the idea of an unchanging, absolute, substance subject, and sees it as a mobile construction, something that can be described only insofar as it “becomes what it is”, that is, as it consciously reacts to its unavoidable destiny.
Locating the Self Within the Soul – Thirteenth-Century Discussions
2008
According to the traditional picture of the history of Western philosophy the High Middle Ages was intellectually Aristotelian, dominated by the Thomist approach. To some extent, this picture was formed already in the Early Modern Era, when many important thinkers distinguished their own philosophy from that of the scholastics. The university philosophy rejected by Descartes, for example, was indeed characteristically Aristotelian, and to a considerable extent even based on a thirteenth-century interpretation of Aristotle by Thomas Aquinas. It may be true that the scholastic philosophy, superseded in the seventeenth century by new approaches, was a direct extension of certain Classical tren…
The Hepatic Expression of Vitamin D Receptor Is Inversely Associated With the Severity of Liver Damage in Genotype 1 Chronic Hepatitis C Patients
2015
BACKGROUND/AIMS: Low 25-hydroxyvitamin D serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC), and experimental evidence suggested a hepatoprotective role of vitamin D via interaction with hepatic vitamin D receptor (VDR). We assessed the hepatic expression of VDR protein and its association with liver disease severity. METHODS: Ninety-one consecutive patients with biopsy-proven G1CHC and available frozen liver tissue were evaluated. Ten subjects without chronic liver diseases and nine patients with autoimmune hepatitis served as controls. The hepatic expression of VDR protein was assessed by Western blot for quantification…
A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegene…
1991
Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA), especially proteinase 3 (C-ANCA), have proved to be a useful clinical tool to support the diagnosis or to monitor disease activity in Wegener's granulomatosis (WG). Till now, human neutrophil granulocytes have represented the major antigen source used to detect antibodies in WG by the immunofluorescence technique (IFT). We have tested serum samples of 164 patients with different connective tissue diseases (50 suffering from clinically active WG) performing IFT on a human renal cancer line (SK-RC11) and have found antibodies against the nuclear and cytoplasmic antigens in 39 patients. C-ANCA+ sera displayed a charact…