Search results for "WESTERN"
showing 10 items of 1138 documents
A Dominant Global Translation Strategy in Thai Translated Novels: The Translations of Religious Markers in Dan Brown’s Thriller Novels
2020
When translation is considered as an integral part of larger social systems (Even-Zohar 1990), the ways in which translations are produced to serve readers’ specificity could be affected. This paper examines whether there is a preference for a specific global translation strategy due to a readership that is specialized in terms of education level. Adopting Venuti’s (1995/2008) division of global translation strategies into exoticizing and domesticating translation, it examines the frequency of local translation strategies, which are part of a global translation strategy, used in translating English-Thai religious markers in Dan Brown’s Angels and Demons, The Da Vinci Code, The Lost Symbol, …
Concepts and Concept Formation in Early Modern Philosophy
2013
The Renaissance witnessed a revival of ancient and Arabic philosophical traditions, such as Platonism, Skepticism and Averroism. Renaissance syncretism was especially influential at the universities in Northern Italy, where several scholars reinterpreted Medieval Latin conceptions of intelligible species. In the sixteenth and seventeenth century, university teaching in most European universities was dominated by second scholasticism. Francisco Suarez was the most philosophically inventive, as well as most influential, among these early modern scholastics (1).
Mapping and expression pattern analysis of key components of the major histocompatibility complex class I antigen processing and presentation pathway…
2001
Renal cell carcinoma (RCC) represent approximately 5% of all cancer deaths. At the time of presentation, over 50% of the patients have already developed locally advanced or metastatic disease with five-year survival rates of less than 20%. Although relative resistant to conventional regimens, RCC are partially susceptible to T cell-based immunotherapy. To further develop this treatment modality, two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) was applied for both the mapping of the key components of the major histocompatibility complex (MHC) class I antigen processing and presentation machinery (APM) and the characterization of the constitutive and cytokine-regulated protein e…
Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent syna…
2013
A major goal in current neuroscience is to understand the causal links connecting protein functions, neural activity, and behavior. The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. Studies using conditional knock-out mice revealed necessary roles of CB1 receptor expressed in dorsal telencephalic glutamatergic neurons in synaptic plasticity and behavior, but whether this expression is also sufficient for brain functions is still to be determined. We applied a genetic strategy to reconstitute full wild-type CB1 receptor functions exclusively in dorsal telencephalic glutamatergic neurons a…
Glutathione regulates telomerase activity in 3T3 fibroblasts.
2004
Changes in telomerase activity have been associated either with cancer, when activity is increased, or with cell cycle arrest when it is decreased. We report that glutathione, a physiological antioxidant present at high intracellular concentrations, regulates telomerase activity in cells in culture. Telomerase activity increases in 3T3 fibroblasts before exponential cell growth. The peak of telomerase activity takes place 24 h after plating and coincides with the maximum levels of glutathione in the cells. When cells are treated with buthionine sulfoximine, which decreases glutathione levels in cells, telomerase activity decreases by 60%, and cell growth is delayed. Glutathione depletion in…
Roads, travelling and communication in the Polish – Lithuanian Commonwealth in the 18th century. Russian and West European visitors’ perspective
2020
W artykule przedstawiony został stan techniczny dróg lądowych i rzecznych, mostów, grobli oraz pozostałej infrastruktury komunikacyjnej w Polsce na podstawie relacji podróżników z zagranicy, w tym Rosjan. Stan oraz jakość lądowych i rzecznych środków transportu był oceniany przez cudzoziemców bardzo nisko, podobnie jak jakość usług oferowanych w przydrożnych karczmach w Polsce i na Litwie. W rezultacie podróżowanie w XVIII w. po Rzeczypospolitej mogło stanowić interesujące doświadczenie. Tak goście z Rosji, jak i z krajów zachodniej Europy natrafiali na wiele przeszkód w trakcie podróży, postrzegając przy tym kraj jako pełen paradoksów. Fatalny stan dróg, przerażające swoim standardem karcz…
Latvijas Vēstures Institūta Žurnāls, 2022, Speciālizlaidums (116)
2022
Speciālizlaidums sagatavots Valsts pētījumu programmas projekta “Indivīda, sabiedrības un valsts mijiedarbība kopējā Latvijas vēstures procesā: vērtību konflikti un kopīgu vērtību veidošanās vēsturiskos lūzumu punktos / Interaction between the individual, the society and the state in process of the history of Latvia: Conflicting values and formation of shared values during historical turning points” (Nr. VPP-IZM-2018/1-0018) ietvaros (vad. G. Zemītis)
Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis
2014
AbstractRedox control of proteins that form disulfide bonds upon oxidative challenge is an emerging topic in the physiological and pathophysiological regulation of protein function. We have investigated the role of the neuronal calcium sensor protein visinin-like protein 1 (VILIP-1) as a novel redox sensor in a cellular system. We have found oxidative stress to trigger dimerization of VILIP-1 within a cellular environment and identified thioredoxin reductase as responsible for facilitating the remonomerization of the dimeric protein. Dimerization is modulated by calcium and not dependent on the myristoylation of VILIP-1. Furthermore, we show by site-directed mutagenesis that dimerization is…
A G468-T AMPD1 mutant allele contributes to the high incidence of myoadenylate deaminase deficiency in the Caucasian population.
2002
Myoadenylate deaminase deficiency is the most common metabolic disorder of skeletal muscle in the Caucasian population, affecting approximately 2% of all individuals. Although most deficient subjects are asymptomatic, some suffer from exercise-induced myalgia suggesting a causal relationship between a lack of enzyme activity and muscle function. In addition, carriers of this derangement in purine nucleotide catabolism may have an adaptive advantage related to clinical outcome in heart disease. The molecular basis of myoadenylate deaminase deficiency in Caucasians has been attributed to a single mutant allele characterized by double C to T transitions at nucleotides +34 and +143 in mRNA enco…
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
2012
Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we developed a dual-luciferase (Renilla and Firefly) reporter system for high-throughput screening (HTS) and monitoring the efficacy of Hsp90 inhibitors in cell culture and live mice. HTS of a 30,176 small-molecule chemical library in cell culture identified a compound, N -(5-methylisoxazol-3-yl)-2-[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio]acetamide (CP9), that binds to Hsp90(α/β) an…