Search results for "WIDE"

showing 10 items of 1235 documents

Experimental observations of upstream overdeepening

2005

The issue of morphodynamic influence in meandering streams is investigated through a series of laboratory experiments on curved and straight flumes. Both qualitative and quantitative observations confirm the suitability of the recent theoretical developments (Zolezzi & Seminara 2001) that indicate the occurrence of two distinct regimes of morphodynamic influence, depending on the value of the width ratio of the channel β. The threshold value βR separating the upstream from the downstream influence regimes coincides with the resonant value discovered by Blondeaux & Seminara (1985). Indeed it is observed that upstream influence may occur only in relatively wide channels, while narrower stream…

BedformMechanics of MaterialsMechanical EngineeringOverdeepeningThe issue of morphodynamic influence in meandering streams is investigated through a series of laboratory experiments on curved and straight flumes. Both qualitative and quantitative observations confirm the suitability of the recent theoretical developments (Zolezzi & Seminara 2001) that indicate the occurrence of two distinct regimes of morphodynamic influence depending on the value of the width ratio of the channel β. The threshold value βR separating the upstream from the downstream influence regimes coincides with the resonant value discovered by Blondeaux & Seminara (1985). Indeed it is observed that upstream influence may occur only in relatively wide channels while narrower streams are dominated by downstream influence. A series of experiments has been carried out in order to check the above theoretical predictions and show for the first time evidence of the occurrence of upstream overdeepening. Two different sets of experiments have been designed where a discontinuity in channel geometry was present such that the channel morphodynamics was influenced in the upstream direction under super-resonant conditions (β >βR) and in the downstream direction under sub-resonant conditions (β <βR). Experimental results give qualitative and quantitative support to the theoretical predictions and allow us to clarify the limits of the linear analysis.MechanicsLinear analysisCondensed Matter PhysicsWidth ratioGeology
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A systematic review of SQL-on-Hadoop by using compact data formats

2016

Article also submitted for publication in Baltic J. Modern Computing (BJMC) on October 5, 2016.

Big DataSQLHDFSGeneral Computer ScienceDatabaseComputer sciencebusiness.industryBig dataAvrocomputer.software_genreParquetWorld Wide WebHadoopSystematic reviewbusinesscomputercomputer.programming_language
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A motif-independent metric for DNA sequence specificity

2011

Abstract Background Genome-wide mapping of protein-DNA interactions has been widely used to investigate biological functions of the genome. An important question is to what extent such interactions are regulated at the DNA sequence level. However, current investigation is hampered by the lack of computational methods for systematic evaluating sequence specificity. Results We present a simple, unbiased quantitative measure for DNA sequence specificity called the Motif Independent Measure (MIM). By analyzing both simulated and real experimental data, we found that the MIM measure can be used to detect sequence specificity independent of presence of transcription factor (TF) binding motifs. We…

Biologylcsh:Computer applications to medicine. Medical informaticsDNA-binding proteinGenomeBiochemistryDNA sequencingCell Line03 medical and health scienceschemistry.chemical_compound0302 clinical medicineStructural BiologyHumansTranscription factorMolecular Biologylcsh:QH301-705.5Sequence Specificity Epigenomics Bioinformatics030304 developmental biologyEpigenomicsGenetics0303 health sciencesBase SequenceSettore INF/01 - InformaticaGenome HumanApplied MathematicsMethodology ArticleDNAComputer Science ApplicationsDNA-Binding Proteinschemistrylcsh:Biology (General)lcsh:R858-859.7Human genomeDNA microarray030217 neurology & neurosurgeryDNAAlgorithmsSoftwareGenome-Wide Association StudyProtein BindingTranscription FactorsBMC Bioinformatics
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EVpedia: a community web portal for extracellular vesicles research

2014

Abstract Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more tha…

Biomedical ResearchDatabases FactualComputer scienceBioactive moleculesMedizinBioinformaticsBiochemistryMathematical SciencesUser-Computer InterfaceNon-U.S. Gov'tdatabasecomputer.programming_languagePLASMAMICROPARTICLESResearch Support Non-U.S. Gov'tbioinformaticsBiological SciencesOriginal PapersCANCERComputer Science ApplicationsIdentification (information)Cell and molecular biologyComputational MathematicsComputational Theory and MathematicsPROTEOMIC ANALYSISMEMBRANE-VESICLESEXPRESSIONStatistics and ProbabilityPROSTASOMESJavaBioinformaticsexosomesResearch SupportExtracellular vesiclesWorld Wide WebDatabasesDELIVERYInformation and Computing SciencesJournal ArticleHumansMembrane vesicleMolecular BiologyFactualEXOSOMESComputational BiologyCELLSDatabase Management SystemsExtracellular SpacecomputerSoftware
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Analysis of Production, Impact, and Scientific Collaboration on Difficult Airway Through the Web of Science and Scopus (1981-2013).

2017

Bibliometrics, the statistical analysis of written publications, is an increasingly popular approach to the assessment of scientific activity. Bibliometrics allows researchers to assess the impact of a field, or research area, and has been used to make decisions regarding research funding. Through bibliometric analysis, we hypothesized that a bibliometric analysis of difficult airway research would demonstrate a growth in authors and articles over time.Using the Web of Science (WoS) and Scopus databases, we conducted a search of published manuscripts on the difficult airway from January 1981 to December 2013. After removal of duplicates, we identified 2412 articles. We then analyzed the art…

Biomedical ResearchTime FactorsInternational CooperationScopusMEDLINEEfficiencyBibliometricsWorld Wide Web03 medical and health sciences0302 clinical medicine030202 anesthesiologyIntubation IntratrachealProduction (economics)MedicineHumans030212 general & internal medicineCooperative BehaviorDifficult airwaybusiness.industrySubject (documents)Databases BibliographicAuthorshipAnesthesiology and Pain MedicinePublishingBibliometricsInterdisciplinary CommunicationDiffusion of InnovationPeriodicals as TopicCitationbusinessAnesthesia and analgesia
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Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results f…

2021

The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010–241909 (Project EU-GEI).

Bipolar DisorderTime FactorsIntelligenceGenome-wide association studyDETERMINANTSpsychosi0302 clinical medicineInterquartile rangeSettore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat.IMPUTATIONpolygenic scorepsychosis0303 health sciencesConfoundingEuropePsychiatry and Mental healthgenome-wide association studieSchizophreniaMajor depressive disorderlipids (amino acids peptides and proteins)Case-Control Studieduration of untreated psychosisBrazilHumanAdultPsychosismedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesTime FactorAcademicSubjects/MED00810DISORDERS1ST EPISODEILLNESSPsychotic Disorderduration of untreated psychosi03 medical and health sciencesInternal medicinemedicineHumansBipolar disorderGENOME-WIDE ASSOCIATIONSettore MED/25 - PsichiatriaMETAANALYSIS030304 developmental biologyDepressive Disorder Majorbusiness.industryCOMPONENTSTREATMENT DELAYmedicine.diseaseTRANSTORNO BIPOLARschizophreniapolygenic scoresPsychotic DisordersCase-Control Studiesdupgenome-wide association studiesbusiness030217 neurology & neurosurgeryRegular ArticlesGenome-Wide Association Study
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Genome-wide homozygosity in Maremmana cattle

2017

The current availability of large numbers of single nucleotide polymorphisms (SNPs) throughout the genome makes these markers particularly suitable for the detection of patterns of genetic diversity and of genome-wide homozygosity in animal populations. The aim of this work was to estimate genetic diversity and homozygosity in the Maremmana cattle breed. We used a sample of 149 animals (males and females) geno-typed with the BovineSNP50 v2 (54K) Illumina BeadChip. After editing for call-rate >0.9 and removing SNP unassigned or on the sex chromosomes, 128 animals and 50,814 SNPs were left. We estimated the following genetic parameters: observed and expected heterozygosity (Ho and He), minor …

Bivine GenomeSettore AGR/17 - Zootecnica Generale E Miglioramento Geneticoruns of homozygosity (ROH)genome-wide homozygositySNPs Markers Bivine Genome Marremmana Breed runs of homozygosity (ROH)maremmana cattleSNPs MarkersSNP markersMarremmana BreedROH Maremmana breed SNPs autozygosity
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Performance Analysis of STBC-OFDM Systems in Temporally or Spatially Correlated Fading Channels

2010

This paper analyzes the performance of space-time block coded orthogonal frequency division multiplexing (OFDM) systems. In our analysis, we abandon the usually made assumption of quasi-static channel conditions. Instead of this, we consider the more general and realistic case that the channel envelope changes during two consecutive transmission time slots. In addition, we take the spatial correlation between sub-channels into account. We first present a general formal expression for the bit error probability (BEP), from which we find analytical solutions for the BEP not only for temporally fading channels but also for spatially correlated channels. The knowledge of the obtained analytical …

Block codeSpatial correlationComputer sciencebusiness.industryOrthogonal frequency-division multiplexingData_CODINGANDINFORMATIONTHEORYSpace–time block codeSignal-to-noise ratioFadingWidebandTransmission timeTelecommunicationsbusinessAlgorithmComputer Science::Information TheoryCommunication channel2010 IEEE Wireless Communication and Networking Conference
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Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

2016

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear(1). Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 x 10(-14)) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role …

Blood Glucose0301 basic medicinemedicine.medical_specialtyendocrine system diseasesGenome-wide association studyType 2 diabetesPolymorphism Single NucleotideWhite PeopleBody Mass Index03 medical and health sciencesQuantitative Trait HeritableInternal medicineDiabetes mellitusGeneticsmedicineHumansHypoglycemic AgentsAlleleGlycemicGlucose Transporter Type 2Glycated HemoglobinbiologyGlucose transporternutritional and metabolic diseasesmedicine.diseaseMetformin3. Good healthMetformin030104 developmental biologyEndocrinologyDiabetes Mellitus Type 2biology.proteinGLUT2Genome-Wide Association Studymedicine.drug
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Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.

2008

Background: The global prevalence of obesity and overweight is increasing rapidly among adults as well as among children and adolescents. Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity. We sequenced regions of the FTO gene to identify novel variants that are associated with obesity and related metabolic traits. Results: We screened exons 3 and 4 including exon-intron boundaries in FTO in 48 obese children and adolescents and identified three novel single nucleotide polymorphism in the fourth intronic region, (c.896 + 37A > G, c.896 + 117C > G and c.896 + 223A > G). We further genotyped c.896 + 223A > G in 962 …

Blood GlucoseMalemedicine.medical_specialtyAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentMedicine (miscellaneous)Single-nucleotide polymorphismOverweightFTO genePolymorphism Single NucleotideBody Mass IndexYoung AdultInsulin resistanceInternal medicinemedicineHumansGenetic Predisposition to DiseaseObesityChildNutrition and Dieteticsbusiness.industryInsulinGenetic Variationmedicine.diseaseObesityGenotype frequencyEndocrinologyPhenotypeFemalemedicine.symptomInsulin ResistancebusinessBody mass indexGenome-Wide Association StudyInternational journal of obesity (2005)
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