Search results for "WIDE"
showing 10 items of 1235 documents
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2013
Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…
The Monod-Wyman-Changeux allosteric model accounts for the quaternary transition dynamics in wild type and a recombinant mutant human hemoglobin
2012
International audience; The acknowledged success of the Monod-Wyman-Changeux (MWC) allosteric model stems from its efficacy in accounting for the functional behavior of many complex proteins starting with hemoglobin (the paradigmatic case) and extending to channels and receptors. The kinetic aspects of the allosteric model, however, have been often neglected, with the exception of hemoglobin and a few other proteins where conformational relaxations can be triggered by a short and intense laser pulse, and monitored by time-resolved optical spectroscopy. Only recently the application of time-resolved wide-angle X-ray scattering (TR-WAXS), a direct structurally sensitive technique, unveiled th…
On Temporal Aspects in Cross-Cultural e-Collaboration Between Finland and Japan Research Teams
2018
Time is an essential dimension in cross-cultural e-collaboration among research project teams. Understanding temporal aspects and project dynamics in cross-cultural research e-collaboration and related processes can improve team members' skills in cross-cultural communication and increase their cultural competence. The present case cultures are Finnish and Japanese, and the case universities are the University of Jyväskylä (Finland) and Keio University (Japan). Three issues are addressed in this article. First, cultural dimensions and time models in the cross-cultural e-collaboration context are discussed. Second, temporal aspects related to e-collaboration activities are introduced. Third,…
Role Scripting as a Tool to Foster Transactivity of Asynchronous Student Discussions
2021
Transactivity of student discussions is crucial in computer-supported collaborative learning (CSCL). However, CSCL learners often lack well-developed argumentation and negotiation skills, which makes it challenging for them to engage in and maintain a transactive discussion. Collaboration scripts have been implemented in CSCL contexts and have demonstrated positive effects on students' collaboration and argumentation skills. Yet, the degree of transactivity of student interactions is rarely addressed directly in CSCL research. Employing a qualitative content analysis approach, this study seeks to understand how a role script affects the transactivity of students' argumentative knowledge co-…
Semantic technologies for industry: From knowledge modeling and integration to intelligent applications
2013
Artificial Intelligence technologies are growingly used within several software systems ranging from Web services to mobile applications. It is by no doubt true that the more AI algorithms and methods are used the more they tend to depart from a pure "AI" spirit and end to refer to the sphere of standard software. In a sense, AI seems strongly connected with ideas, methods and tools that are not (yet) used by the general public. On the contrary, a more realistic view of it would be a rich and pervading set of successful paradigms and approaches. Industry is currently perceiving semantic technologies as a key contribution of AI to innovation. In this paper a survey of current industrial expe…
Association of a single nucleotide polymorphism of RANK gene with blood pressure in Spanish women
2020
Abstract In addition to governing key functions in bone metabolism and the immune system, the RANK/RANKL/OPG system plays a role in the vascular system, particularly in vascular calcification and atherosclerosis. Given that these 2 phenotypes are considered a major cause of high blood pressure (BP), in this study we analyzed the association of SNPs in RANK and OPG genes with blood pressure. An observational study was conducted of 2 SNPs in the RANK gene (rs884205 and rs78326403) and 1 in the OPG gene (rs4876869) with systolic (SBP) and diastolic blood pressure (DBP) in a cohort of 695 women. Data analysis revealed a statistically significant association between the SNP rs884205 and BP press…
A simulation of disagreement for control of rational cheating in peer review
2013
Understanding the peer review process could help research and shed light on the mechanisms that underlie crowdsourcing. In this paper, we present an agent-based model of peer review built on three entities - the paper, the scientist and the conference. The system is implemented on a BDI platform (Jason) that allows to define a rich model of scoring, evaluating and selecting papers for conferences. Then, we propose a programme committee update mechanism based on disagreement control that is able to remove reviewers applying a strategy aimed to prevent papers better than their own to be accepted (rational cheating). We analyze a homogeneous scenario, where all conferences aim to the same leve…
Brima: Low-Overhead Browser-Only Image Annotation Tool (Preprint)
2021
Image annotation and large annotated datasets are crucial parts within the Computer Vision and Artificial Intelligence this http URL the same time, it is well-known and acknowledged by the research community that the image annotation process is challenging, time-consuming and hard to scale. Therefore, the researchers and practitioners are always seeking ways to perform the annotations easier, faster, and at higher quality. Even though several widely used tools exist and the tools' landscape evolved considerably, most of the tools still require intricate technical setups and high levels of technical savviness from its operators and crowdsource contributors. In order to address such challenge…
Integration of distributed healthcare records: publishing legacy data as XML documents compliant with CEN/TC251 ENV13606
2003
To support co-operative work among health professionals and institutions it is necessary to share healthcare information about patients in a meaningful way. But, nowadays, in most hospitals health data are distributed across several information systems whose interconnection is difficult to achieve, this leads to the so-called islands of information. This paper briefly describes the architecture, design and implementation of the PANGEA system. PANGEA allows healthcare professionals to access patient information stored in heterogeneous autonomous information systems through a set of formal aggregates of health data based on the European pre-standard of Healthcare Record Architecture ENV13606 …