Search results for "WL"
showing 10 items of 4149 documents
The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions
2000
The present experiments were designed to extend previous work showing that acute intermittent (-)nicotine treatment upregulates the level of fibroblast growth factor-2 (FGF2) mRNA in several rat brain regions, by the use of the nicotinic acetylcholine receptor (nAChR) agonist ABT-594 with preferential selectivity for the alpha4beta2 nAChR subtype. ABT594 treatment led to a well-defined temporal and regional upregulation of FGF-2 mRNA. A double labelling analysis showed that the up-regulation of FGF-2 mRNA involves both neuronal and non-neuronal cells. The effects of ABT-594 on FGF-2 expression were antagonized by the preferential alpha4beta2 antagonist dihydrobetaerythroidine (DHbetaE), but…
Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity
2011
Background The hippocampus and its 5-hydroxytryptamine transmission plays an important role in depression related to its involvement in limbic circuit plasticity. Methods The analysis was made with bioluminescence resonance energy transfer, co-immunoprecipitation, in situ proximity ligation assay, binding assay, in cell western and the forced swim test. Results Using bioluminescence resonance energy transfer analysis, fibroblast growth factor receptor 1 (FGFR1)-5-hydroxytryptamine 1A (5-HT1A) receptor complexes have been demonstrated and their specificity and agonist modulation characterized. Their presence based on co-immunoprecipitation and proximity ligation assay has also been indicated…
Functional evidence of inverse agonism in vascular smooth muscle
1996
1. In the present study, depletion of internal Ca2+ stores sensitive to noradrenaline (1 microM) in rat aorta, is the signal for the entry of extracellular Ca2+, not only to refill the stores but also, in our experimental conditions, to activate the contractile proteins. This induces an increase in the resting tone that constitutes, the first functional evidence of this Ca2+ entry. 2. The fact that methoxamine (100 microM) reproduces the same processes as noradrenaline but clonidine (1 microM) does not, indicates that alpha(1)-adrenoceptor activation is related to the increase in the resting tone observed after depletion of adrenoceptor-sensitive internal Ca2+-stores. 3. Benoxathian and WB …
MANAGING INETEGRATED SYSTEMS OF INFORMATION STREAMS WITHIN AGRARIAN ENTERPRISES
2016
Managing integrated systems of information streams within agrarian enterprises / Kalinichenko А. etc. Zeszyty Naukowe Politechniki Czestochowskiej, Zarządzanie. 2016. Nr 21. P. 150–158
Tell me a story and I will tell you who you are! Lens model analyses of personality and creative writing
2010
Abstract We elucidated the accuracy of personality judgments based on creative writing by means of lens model analyses. Targets ( N = 79) wrote short stories with five predefined words. Observers rated the Big Five dimensions and general knowledge of the targets who wrote these stories. Three main findings were revealed: (a) the Big Five and general knowledge were consensually judged by observers; (b) judgments of openness to experience, agreeableness, and general knowledge were accurate; and (c) accuracies were achieved due to the correct usage of valid cues. Additionally, we replicated all results in a second sample of targets ( N = 126). Results are discussed in comparison to other are…
Examining Sources of Farmers’ Knowledge as a Premise Behind Realization of the Smart Village Conception. A Case Study of Opole Region
2019
The aim of the study is to point to the need of doing research on the system of agricultural knowledge and information as a premise behind realization of the conception of smart village in the territorial framework. Accepting the assumption that intelligent agriculture lies at the foundation of transformation of rural areas, the author indicates the role of the system of agricultural knowledge and information in the process of modernization of agricultural holdings. In the article, questionnaire-based survey research was used in relation to the sustainable development of agriculture in Opole Region. In order to assess the level of adaptation of agricultural holdings to economy based on know…
The contribution of the European Society for Soil Conservation (ESSC) to scientific knowledge, education and sustainability
2019
Soil is an integral component of the global environmental system which supports the quality and diversity of terrestrial life on Earth. Therefore, it is vital to consider the processes and impacts of soil degradation on society, especially on the provision of environmental goods and services, including food security and climate change mitigation and adaptation. Scientific societies devoted to soil science play significant roles in reducing soil degradation and promoting soil conservation by advancing scientific knowledge, education and environmental sustainability. The ESSC was founded on 4 November 1988, with the aims to: 1. Support research on soil degradation, soil protection and soil an…
Les dynamiques du périurbain dijonnais entre 1990 et 1999
2009
Un étalement urbain accompagne désormais la croissance des villes, notamment les plus grandes. Principalement expliqué par un desserrement résidentiel, il est aussi la résultante des dynamiques de centralisation de l’emploi et de spécialisation des zones d’activité à l’intérieur des aires urbaines. L’exemple dijonnais met bien en lumière ce double mouvement qui affecte les communes de sa périphérie et contribue à accroître les mobilités. Urban sprawl arises from the growth of cities, especially of the biggest cities. This urban sprawl is accounted for mainly by residential clearing. It results also from the dynamics of centralization of employment and from specialization of activity zones i…
Motivic Pattern Extraction in Symbolic Domain
2008
This chapter offers an overview of computational research in motivic pattern extraction. The central questions underlying the topic, concerning the formalization of the motivic structures, the matching strategies and the filtering of the results, have been addressed in various ways. A detailed analysis of these problems leads to the proposal of a new methodology, which will be developed throughout the study. One main conclusion of this review is that the problems cannot be tackled using purely mathematic or geometric heuristics or classical engineering tools, but require also a detailed understanding of the multiple constraints derived by the underlying cognitive context.
Implementation Challenges for Supporting Coworking Virtual Enterprises
2013
The creation of co working alliances is usually restricted to the coworkers in the same workspace. However, they might not necessarily be best partners to take advantage of a collaboration opportunity. To break the spatial constrains and find the best partners irrespective of their co working spaces location, our proposal is to represent and manage the co working alliances as virtual enterprises (VEs) and to develop a multi-agent system (MAS) that serves as Virtual Breeding Environment (VBE). In this paper we provide the basis for the future development of this system. Thus, we introduce the co working VEs distinguishing features and the initial proposals on how to implement the MAS to addr…