Search results for "WTH"
showing 10 items of 5145 documents
Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
2020
Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003-2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnanc…
Respiration and growth rates of F0 and F1 larval and juvenile European seabass Dicentrarchus labrax in response to ocean acidification and warming
2022
Ongoing climate change is leading to warmer and more acidic oceans. The future distribution of fish within the oceans depends on their capacity to adapt to these new environments. Only few studies have examined the effects of ocean acidification (OA) and warming (OW) on the metabolism of long-lived fish over successive generations. We therefore aimed to investigate the effect of OA on larval and juvenile growth and metabolism on two successive generations of European sea bass (Dicentrarchus labrax L.) as well as the effect of OAW on larval and juvenile growth and metabolism of the second generation. European sea bass is a large economically important fish species with a long generation time…
A multilevel latent growth modelling of the longitudinal changes in motivation regulations in physical education
2015
The purpose of this study was to examine individual- and classroom-level differences in the longitudinal change in motivational regulations during physical education students' transition from elementary (Grade 6) across middle school (Grades 7 to 9). A sample of 757 Finnish adolescents (M = 12.71, SD = 0.23) participated in this study. Participants of the study responded to questionnaires collected six times. A multilevel latent growth modelling approach was used to analyze the data. Results showed that motivational regulations in physical education developed at different rates during middle school. More specifically, students': (a) identified regulation increased across Grades 6 to 9; (b) …
Antecedents and Consequences of Student-Athletes’ Identity Profiles in Upper Secondary School
2020
The present study examined the identity profiles that upper-secondary-school Finnish student-athletes show, and the extent to which these profiles were associated with their athletic and academic achievements and withdrawal from sports and school. A total of 391 adolescent athletes (51% females) completed assessments of student and athletic identity four times during their time in upper secondary school. Using growth mixture modeling, three groups were identified: (a) dual identity (77%), (b) changing identity (5%), and (c) athletic identity (18%). The higher the academic achievement was at Time 1, the more likely the athletes were to show dual identity than athletic identity profile. Simil…
Trajectory subgroups of perceived emotional support from teachers : Associations with change in mastery climate and intentions to quit upper secondar…
2022
The aims of this three-wave longitudinal study were to identify and describe trajectories of perceived emotional support from teachers and investigate whether these trajectories were related to the development of intentions to quit upper secondary school via change in perceived mastery climate. Among 1379 Norwegian upper secondary school students, three trajectory subgroups were identified: stable high (84.9%), decreasing (7.8%), and low increasing (7.3%). The subgroups differed in levels of achievement ambition and academic self-concept. Further, a parallel process latent growth curve model revealed essential associations with change in intentions to quit school. Specifically, students wit…
Aspects Regarding Human Resources Management Streamlining within National and International Organizations
2014
Abstract The entire world is changing in order to achieve performance as an essential element designed to meet the needs and interests of individuals, organizations and society, as a whole. For that, it is necessary to efficiently know and use all the resources and possibilities possessed by the organization, among which human resources Management streamlining acquires new dimensions and special significances. Therefore, approaching certain theoretical aspects regarding the necessity and content of human resources Management streamlining within national and international organizations, as well as psychosocial valences in this field represent important social and objective matters, which are…
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma
2017
Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…
Cell-cycle control in cell-biomaterial interactions
2000
Current biocompatibility testing involves the demonstration of cell proliferation, which is usually interpreted as a sign of positive biocompatibility when the materials sustain cell proliferation. As the field of biomaterials research is rapidly moving toward tissue-engineered devices and hybrid organs, control of cell function has become a main topic. Cell function, which involves specific differentiation pathways, cannot be separated from cell-cycle control. The study of cell-cycle control is an important extension of routine proliferation assays and has extensive roots in developmental and tumor biology. We studied the expression of the tumour suppressor gene p53 and the proliferation-a…
p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53
2010
10 p.-5 fig.
Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation
2009
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …