Search results for "Well-being"
showing 10 items of 1190 documents
Happiness in advanced adulthood and elderly: The role of positive emotions, flourishing and mindfulness as wellbeing factors for successful ageing
2019
This study critically analyses the role of Happiness among the Portuguese elderly. The term is understood as a grouping of variables including Subjective Well-being, defined by satisfaction with life, positive and negative affects, flourishing, optimism and pessimism, positive and negative emotions, meaning of life, religiosity, Spirituality, and mindfulness. The qualities of Happiness are explored as they contribute to successful ageing and higher levels of Happiness in the elderly. We conducted a correlational study of 329 participants, aged 55 to 98 years. We used several questionnaires to gather data as a socio-demographic questionnaire, Satisfaction with Life Scale (SWLS), Positive and…
Do aging employees benefit from self-regulative strategies? : A follow-up study
2020
SOC-strategies (selection, optimization, and compensation) are crucial for well-being and adaptation throughout the life course. The workforce is aging rapidly, thus the age-conditional premises of SOC theory require attention. This study explored (1) whether older employees used SOC strategies more often (compared to younger employees), and (2) whether older employees benefited more from SOC strategies in relation to occupational well-being (job burnout, work engagement). The study was based on follow-up data including three occupational subsamples of different age (N = 1,020). There were no significant age-conditional differences in the take-up of SOC strategies. However, older (white-col…
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness…
2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions a…
Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults
2020
Abstract Background In 2016, an expert working group was convened under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and formulated consensus recommendations for the conduct of clinical trials for drugs to prevent or treat sarcopenia. Aims The objective of the current paper is to provide a 2020 update of the previous recommendations in accordance with the evidence that has become available since our original recommendations. Methods This paper is based on literature reviews performed by members of the ESCEO working group and followed up with face to face meetings organized for the whole group to make amendments and discuss…
The age and well-being “paradox”: a longitudinal and multidimensional reconsideration
2022
This paper explores qualifcations to the much-discussed paradox that although aging is associated with multiple physical and social losses, subjective well-being (SWB) is stable or increasing in later life. We explore age-related changes in cognitive, afective, and eudaimonic dimensions in three waves of data spanning up to 15 years from the Norwegian NorLAG study (N=4,944, age 40−95). We employ fxed-efect models to examine the nature and predictors of aging efects on SWB. Results indicate a general pattern of stability well into older age, but negative changes in advanced age across well-being measures. Declines in SWB are less pronounced and with a later onset for the cognitive compared w…
Work-family conflict and its relations to well-being: the role of personality as a moderating factor
2003
Contains fulltext : 63496.pdf (Publisher’s version ) (Closed access) The aim of the present study was to examine the role of the Big Five personality dimensions as possible moderating factors between two types of work–family conflicts: work interference with family (WIF); and family interference with work (FIW); and their relationship to well-being in the domains of work and family generally as well. The participants were fathers (n=296) who took part in a national family research project in the Netherlands in 1995. All fathers were employed full-time. The results showed that emotional stability moderated the relationships between WIF and job exhaustion and between WIF and depression. In ad…
Receptor Activator of NF-kB (RANK) Expression in Primary Tumors Associates with Bone Metastasis Occurrence in Breast Cancer Patients
2011
Background\ud Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG.\ud \ud Materials and Methods\ud We examined mRNA expression levels of RANKL/RANK/OPG in a publicly available microarray dataset of 295 primary breast cancer patients. We next analyzed RANK expression by immunohistochemistry in an independent series of 93 primary breast cancer specimens and investigated a possible association with clinicopathological parameters, bone recurrence and surviv…
Collecting and Using Students’ Digital Well-Being Data in Multidisciplinary Teaching
2018
This article examines how students (N=198; aged 13 to 17) experienced the new methods for sensor-based learning in multidisciplinary teaching in lower and upper secondary education that combine the use of new sensor technology and learning from self-produced well-being data. The aim was to explore how students perceived new methods from the point of view of their learning and did the teaching methods provide new information that could promote their own well-being. We also aimed to find out how to collect digital well-being data from a large number of students and how the collected big data set can be utilized to predict school success from the students’ well-being data by using machine lear…
Including an environmental quality index in a demographic model
2016
This paper presents a new well-being index which allows environmental quality to be measured through CO2 emissions, renewable energies and nuclear power. Its formula derives from a geometric mean used to calculate which things in the human production system warm the planet and which do not. This index has been introduced into a gender-defined stochastic population dynamic mathematical model which measures well-being in a country. The main variables in this model are rates of death, birth, emigration and immigration, as well as three UN indices: Human Development Index, Gender Development Index and Gender Empowerment Index. This model has been extended with variables that allow an environmen…