Search results for "Wester"

Spleen Tyrosine Kinase (SYK) in the Progression of Peritoneal Fibrosis Through Activation of the TGF-β1/Smad3 Signaling Pathway.

2019

BACKGROUND Long-term exposure to hypertonic and high glucose in peritoneal dialysis fluid can result in peritoneal fibrosis. Spleen tyrosine kinase (SYK) has a role in inflammation and fibrosis. This study aimed to investigate the role of SYK in an in vivo rat model of peritoneal fibrosis and in rat peritoneal mesothelial cells (PMCs) in vitro and to investigate the underlying mechanisms. MATERIAL AND METHODS Sprague-Dawley rats (N=24) were randomized into the sham control group (N=6); the peritoneal fibrosis group (N=6) treated with intraperitoneal chlorhexidine digluconate; the SYK inhibitor group (N=6), treated with chlorhexidine digluconate and fostamatinib; and the TGF-s inhibitor grou…

A New Extraordinary Dream: A Study of Late-Qing Foreign Fiction Translations from the Perspective of Titology

2022

In the early stage of the introduction of foreign fiction to Chinese readers, newspapers and magazines played a pioneering role in the development of the discourse on the social role of fiction in modern Chinese society. This is particularly true for Shanghai newspaper Shenbao, which introduced a large number of Western novels, trying to fuel readers’ curiosity while avoiding any possible discomfort caused by foreignising or destabilising content. As a privileged type of paratext and the first element with whom readers came into contact, titles and their translations were key elements for promoting the new literary section and increasing daily sales. By adopting the theoretical framework of…

Stress response in mesoangioblast stem cells

2006

Stem cells are presumed to survive various stresses, since they are recruited to areas of tissue damage and regeneration, where inflammatory cytokines and cytotoxic cells may result in severe cell injury. We explored the ability of mesoangioblasts to respond to different cell stresses such as heat, heavy metals and osmotic stress, by analyzing heat shock protein (HSP)70 synthesis as a stress indicator. We found that the A6 mesoangioblast stem cells constitutively synthesize HSP70 in a heat shock transcription factor (HSF)-independent way. However, A6 respond to heat shock and cadmium treatment by synthesizing HSP70 over the constitutive expression and this synthesis is HSF1 dependent. The e…

TFIIH Operates through an Expanded Proximal Promoter To Fine-Tune c-myc Expression

2004

A continuous stream of activating and repressing signals is processed by the transcription complex paused at the promoter of the c-myc proto-oncogene. The general transcription factor IIH (TFIIH) is held at promoters prior to promoter escape and so is well situated to channel the input of activators and repressors to modulate c-myc expression. We have compared cells expressing only a mutated p89 (xeroderma pigmentosum complementation group B [XPB]), the largest TFIIH subunit, with the same cells functionally complemented with the wild-type protein (XPB/wt-p89). Here, we show structural, compositional, and functional differences in transcription complexes between XPB and XPB/wt-89 cells at t…

Autumn migration of soaring birds through the Gebel El Zeit Important Bird Area (IBA), Egypt, threatened by wind farm projects

2011

SummarySystematic bird observations were performed during autumn 2006 in the migration bottleneck area of Zeit Bay, Egypt (27.73°N, 33.51°E), situated on the coast of the Gulf of Suez, opposite southern Sinai. Owing to the strong northerly winds in that area, considerable pressure exists to construct wind farms. A total of 145,432 soaring birds, including 134,599 storks and 9,376 raptors over a period of 453.6 hours were observed between 20 August and 29 October by two teams working daily in two shifts. White Stork Ciconia ciconia and European Honey Buzzard Pernis apivorus were the most numerous species (91.4% and 5.7% respectively) of all soaring birds observed. As both species migrate ear…

Cittadinizzazione e policy migratorie nella Sicilia occidentale : Progettare servizi innovativi rafforzando le Pubbliche Amministrazioni in attuazion…

2021

L’accesso ai servizi della pubblica amministrazione è spesso, per la popolazione migrante, un cercare la chiave giusta fra un numero spropositato di chiavistelli. Evidenziare come l’inserimento di alcuni servizi innovativi, fra i quali gli sportelli Mi.Main (Migration Mainstreaming) progettati e implementati da giovani laureati all’interno degli uffici della P.A., abbia di fatto favorito processi di “cittadinizzazione”, è stato lo scopo di questo volume. Preliminari ad ogni processo di inclusione sono infatti gli “atti di cittadinanza” che attraversano e ancorano l’universalità dei diritti umani al riconoscimento dei bisogni e delle priorità della persona. Questo volume, descrive come due t…

From Theatre to Theatricality—How to Construct Reality

1995

At the end of the nineteenth century, the dominance of language, so typical of Western culture since the Renaissance, was increasingly challenged. As early as 1876, Nietzsche wrote on Richard Wagner in Thoughts Out of Season:He was the first to recognize an evil which is as widespread as civilization itself among men; language is everywhere diseased, and the burden of this terrible disease weighs heavily upon the whole of man's development. Inasmuch as language has retreated ever more and more from its true province— the expression of strong feelings, which it was once able to convey in all their simplicity—and has always had to strain after the practically impossible achievement of communi…

ANALYSIS OF CLAYEY RAW MATERIALS IN WESTERN SICILY: ARCHEOLOGICAL AND ARCHAEOMETRIC INFERENCES

2007

Cloning and Characterization of Overlapping DNA Fragments of the Toxin A Gene of Clostridium difficile

1989

Clostridium difficile, a human pathogen, produces two very large protein toxins, A and B (250-600 kDa), which resist dissociation into subunits. To clone the toxin A gene, a genomic library of 3-8 kb chromosomal DNA fragments of C. difficile strain VPI 10463 established in pUC12 was screened with a rabbit polyclonal toxin A antiserum. Thirty-five clones were isolated which carried 2.5-7.0 kb inserts representing a 10 kb region of the C. difficile genome. All the inserts were oriented in the same direction, suggesting that toxin A gene expression was under control of the lac promoter of the pUC12 vector. Western blot experiments revealed the presence of low amounts of fusion proteins of vari…

Musical training facilitates the neural discrimination of major versus minor chords in 13-year-old children

2012

Music practice since childhood affects the development of hearing skills. An important classification in Western music is the chords’ major-minor dichotomy. Its preattentive auditory discrimination was studied here using a mismatch negativity (MMN) paradigm in 13-year-olds with active hobbies, music-related (music group) or other (control group). In a context of root major chords, root minor chords and inverted major chords were presented infrequently. The interval structure of inverted majors differs more from root majors than the interval structure of root minors. However, the identity of the chords is the same in inverted and root majors (major), but different in root minors. The deviant…