Search results for "Western"
showing 10 items of 1138 documents
Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-di…
2011
X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of the peroxisomal ATP-binding cassette transporter D (ABCD1) and from single peroxisomal enzyme deficiency (Acyl-CoA oxidase1: ACOX1), respectively. As these proteins are involved in the catabolism of very long chain fatty acids (VLCFA: C24:0, C26:0), X-ALD and P-NALD patients are characterized by the accumulation of VLCFA in plasma and tissues. Since peroxisomes are involved in the metabolism of reactive oxygen species (ROS) and nitrogen species (RNS), we examined the impact of VLCFA on the oxidative status of 158N murine o…
Riflessioni conclusive
2015
The rural sanctuary in the San Cataldo district, between the territories of Terrasini and Partinico, is mentioned by the written sources since the XII century, but the surviving architectural structures date back to the 16th century. The site, abandoned since the 1950s and now restored by the Soprintendenza ai Beni Culturali of Palermo who carried out archaeological excavations in this area in 2000 and 2014, over the centuries has been an important aggregation pole in order to the cultural and religious identity of the rural communities in northwestern Sicily, in relation to the fertile hinterland through the Roma viability (via consolare Valeria) .
WATER MASSES EXCHANGE THROUGH THE STRAIT OF SICILY DURING THE LAST DEGLACIAL PERIOD AND THE HOLOCENE
2022
The main goal of this thesis is to explore the inter-basin connection between the eastern and the western Mediterranean (E- and W-Med, respectively) during the last deglacial and Holocene periods (last 15 kyr). The thesis is based on the study of a sediment core recovered at the west flank of Sicily channel (W-Sicily), strategically located under the current path of the surface Atlantic waters and directly below the present-day hydrographic boundary layer between the Eastern Mediterranean Sourced Water (EMSW) and the Western Mediterranean Deep Water (WMDW). This key location allow to explore past changes in both surface and deep water exchange between the E and the W-Med. In this thesis, a …
Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy.
2021
Visceral leishmaniasis (VL) caused by Leishmania infantum is endemic in the Mediterranean basin with most of the infected human patients remaining asymptomatic. Recently, the saurian-associated Leishmania tarentolae was detected in human blood donors and in sheltered dogs. The circulation of L. infantum and L. tarentolae was investigated in humans, dogs and cats living in the Pelagie islands (Sicily, Italy) by multiple serological and molecular testing. Human serum samples (n = 346) were tested to assess the exposure to L. infantum by immunofluorescence antibody test (IFAT), enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) and to L. tarentolae by IFAT. Meanwhile, sera from do…
Impact of the high share of converter-interfaced generation on electromechanical oscillations in Continental Europe power system
2020
This study investigates the effects of converter-interfaced generation integration on the dynamic response of the power system of Continental Europe. The system is analysed with a large-scale dynamic model of the entire synchronous area, considering different instantaneous integration percentages of converter-interfaced generation across the system. The study focuses on the reduction of the overall available kinetic energy and the impact on frequency dynamics and system oscillations. The dynamic model of the system originally provided by ENTSO-E is further developed according to a specific methodology, replacing a determined amount of synchronous generation and introducing a corresponding a…
Parapatric diversification after post-glacial range expansion in the gall flyUrophora cardui(Tephritidae)
2010
Aim Primary and secondary genetic clines in post-glacial colonized regions have different implications for biogeographic distributions and the origin of species. Primary clines arise in situ after colonization as adaptive responses to environmental gradients, while secondary clines are caused by contact between vicariant lineages. Here we analyse primary versus secondary origin of a genetic cline in the tephritid fly Urophora cardui in Jutland, Denmark, in a post-glacial landscape. Location Western Palaearctic. Methods Phylogeographic and demographic analyses of U. cardui based on mitochondrial DNA (mtDNA) genealogies, hierarchical genetic variance tests based on allozymes and distributi…
Taxonomy and evolution of the Convolvulus sabatius complex (Convolvulaceae)
2010
A revision of the Convolvulus sabatius complex is presented and five taxa are now recognised. Convolvulus valentinus is re-circumscribed to comprise only blue-flowered individuals. Yellow-flowered plants previously referred to this species are transferred to C. supinus where they are recognised as a distinct variety: C. supinus var. melliflorus, comb nov. Variation in intensity of flower colour, pubescence and leaf shape among blue-flowered C. valentinus is highly variable within populations and in contrast to earlier treatments, no infraspecific taxa based on these traits are recognised. Despite suggestions to the contrary, the delimitation of the cultivated ornamental C. sabatius and its …
The dialogue between east and west in the construction of gender photography as support of discourse and resistance
2018
En el marco de la globalización, en las nuevas narrativas de género se han producido cambios conceptuales con nuevos posicionamientos críticos y de resistencia. Mujeres creadoras de otras culturas, diferentes al mundo occidental, han trabajado para denunciar situaciones o poner en valor el empoderamiento de las mujeres como protagonistas de su destino. Y es en esta línea donde las mujeres artistas han aportado sus propuestas feministas y de resistencia. Los objetivos de este trabajo se centran en dos ejes conceptuales: a) analizar la situación de las mujeres en el contexto de los países islámicos y b), mostrar, a través del trabajo de fotógrafas procedentes de estos países, como se está con…
Identification and characterization of autoantibodies against catalase and α-enolase in patients with primary sclerosing cholangitis
1998
SUMMARY Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Recent studies have shown that genetic factors and both cellular and humoral immunological abnormalities are important in the pathogenesis of PSC. The most prominent autoantibodies in PSC are anti-neutrophil cytoplasmic antibodies (ANCA). The autoepitopes of ANCA in PSC are not well defined. The aim of this study was to identify corresponding ANCA autoantigens in patients with PSC. A biochemical approach with enrichment and partial purification of soluble neutrophil proteins, detection of autoantibodies by Western blot and partial amino acid sequencing were used. Two new autoantigen/aut…
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
2014
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387)(1-3). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 313 (GSK-3 beta)(4). Mutant CCND2 was resistant to proteasomal degradation in vitro compared to wild-type CCND2. The PI3K-AKT pathway modulates GSK-3 beta activity(4), and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND…