Search results for "Western"
showing 10 items of 1138 documents
Liver X Receptor–Mediated Induction of Cholesteryl Ester Transfer Protein Expression Is Selectively Impaired in Inflammatory Macrophages
2009
Objective— Cholesteryl ester transfer protein (CETP) is a target gene for the liver X receptor (LXR). The aim of this study was to further explore this regulation in the monocyte-macrophage lineage and its modulation by lipid loading and inflammation, which are key steps in the process of atherogenesis. Methods and Results— Exposure of bone marrow–derived macrophages from human CETP transgenic mice to the T0901317 LXR agonist increased CETP, PLTP, and ABCA1 mRNA levels. T0901317 also markedly increased CETP mRNA levels and CETP production in human differentiated macrophages, whereas it had no effect on CETP expression in human peripheral blood monocytes. In inflammatory mouse and human mac…
The Impact of Artificial Intelligence on Traditional Chinese Medicine
2021
Traditional Chinese Medicine (TCM) is a well-established medical system with a long history. Currently, artificial intelligence (AI) is rapidly expanding in many fields including TCM. AI will significantly improve the reliability and accuracy of diagnostics, thus increasing the use of effective therapeutic methods for patients. This systematic review provides an updated overview on the major breakthroughs in the field of AI-assisted TCM four diagnostic methods, syndrome differentiation, and treatment. AI-assisted TCM diagnosis is mainly based on digital data collected by modern electronic instruments, which makes TCM diagnosis more quantitative, objective, and standardized. As a result, th…
Reflexive Modernization and the Disembedding of Jūdō from 1946 to the 2000 Sydney Olympics
2004
This article considers some of the sociologically significant changes to jūdō in its process of transformation from a Budō based martial art into a modern competitive spectator sport. Taking the period of time from 1946 until the Sydney Olympics, an examination is undertaken using Giddens’s notion of reflexive modernization in which key aspects of the original jūdō are disembedded or ‘lifted out’ of the practice. They are then re-embedded with western structures, practices and meanings. Central themes to emerge from this analysis are the social forces of internationalization, institutionalization and commodification of jūdō over this period, each of which contributes to a reflexive moderni…
Modeling Metaphysics: The Rise of Simulation and the Reversal of Platonism
2019
Philosophical reflection on and around Modeling and Simulation (M&S) is often focused on the ethical and epistemological implications of empirical findings or innovative methods within the field. In this paper I highlight some of the metaphysical implications of developments within M&S. I argue that the rise of simulation within and across scientific disciplines is accelerating the reversal of Platonism, whose emphasis on transcendence and reliance on hierarchical, static categories has dominated western philosophy for over two millennia. The success of M&S methodologies opens up new conceptual space for articulating a metaphysics of immanence that may provide a more adequate basis for unde…
Carbon isotope stratigraphy, magnetostratigraphy, and 40Ar/39Ar age of the Cretaceous South Atlantic coast, Namibe Basin, Angola
2014
This publication results from Projecto PaleoAngola, an international cooperative research effort among the contributing authors and their institutions, funded by the National Geographic Society, the Petroleum Research Fund of the American Chemical Society, Sonangol E.P., Esso Angola, Fundacao Vida of Angola, LS Films, Maersk, Damco, Safmarine, ISEM at SMU, The Royal Dutch Embassy in Luanda, TAP Airlines, Royal Dutch Airlines, The Saurus Institute, and the Perot Museum of Nature and Science. JS was additionally funded by Yale University and the Alfred Kordelin Foundation. We dedicate this contribution to the late Kalunga Lima, our friend and colleague in Projecto PaleoAngola. We thank Margar…
Parasite fauna and community structure of bathydemersal fishes: Notacanthus bonaparte (Osteichthyes), Etmopterus spinax and Deania profundorum (Chond…
2017
Resumen El mar profundo es el mayor bioma de la tierra y el menos estudiado (Ramirez-Llodra et al. 2010). Si bien inicialmente el mar profundo se consideró como un ambiente muy estable con variaciones muy leves por debajo de la termoclina permanente, los estudios realizados en las últimas décadas indican que el mar profundo es un ambiente más dinámico de lo que se pensaba (Gage 2003, Ramirez-Llodra et al. 2010). La variabilidad natural de los procesos que tiene lugar en los hábitats del mar profundo tiene su origen en diferentes factores entre los que se encuentran las corrientes horizontales de masas de agua de grandes dimensiones dirigidas por las corrientes circunglobales, las cuales pue…
The combination of PDE4 and PDE5 inhibitors reduces YAP expression in IPF
2017
Background: Pathological fibrosis is associated with repeated episodes of injury to alveolar epithelial cells of largely. Yes-associated protein (YAP) is prominently expressed in fibrotic lung. Roflumilast has demonstrated to exhibit anti-fibrosis effects, while PDE5 inhibitors (sildenafil) combinated with PDE4 inhibitors reduce fibrotic-effects secondary to TGFs1. Apparently, no studies of PDE4 and PDE5 inhibitors on YAP expression there are. Objectives: To study the effects from adding a sildenafil to Roflumilast N- oxide (RNO) on TGF-β/SMAD3/YAP pathway in IPF in vitro models. Methods: A549 cells were pre-incubated with therapeutical concentrations of RNO (2nM) and/or sildenafil (10nM) a…
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by su…
2010
Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate the activity of alpha-secretase, the major preventive secretase of Alzheimer's disease. Statins can increase the alpha-secretase activity by their cholesterol-lowering properties as well as by impairment of isoprenoids synthesis. In the present study, we elucidate the contribution of these pathways in alpha-secretase activation. We demonstrate that zaragozic acid, a potent inhibitor of squalene synthase which blocks cholesterol synthesis but allows synthesis of isoprenoids, also stimulates alpha-secretase activity. Treatment of human n…
Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses.
2020
Abstract Background Carnosic acid (CA) is one of the main constituents in rosemary extract. It possesses valuable pharmacological properties, including anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer activities. Numerous in vitro and in vivo studies investigated the anticancer profile of CA and emphasized its potentiality for cancer treatment. Nevertheless, the role of multidrug-resistance (MDR) related mechanisms for CA's anticancer effect is not yet known. Purpose We investigated the cytotoxicity of CA against known mechanisms of anticancer drug resistance (P-gp, ABCB5, BCRP, EGFR and p53) and determined novel putative molecular factors associated with cellular response to…
Un nuevo suido con dientes yugales tubulidentados e hipselorrizos del Mioceno inferior de Córcoles, España
2018
[EN] Excavations at Córcoles, Guadalajara, Spain (MN 4) in October 1987, yielded a mandible and several isolated teeth of a strange suiform with tubulidentate cheek teeth, initially interpreted to be the remains of Tubulidentata. The specimens are complete enough to remove any doubt about which Order (Artiodactyla) and Superfamily (Suoidea) they belong to. They are here attributed to the Family Doliochoeridae, being related to the genera Bransatochoerus (MP 30) and Lorancahyus (MN 2) both of which have hypsorhizic cheek teeth, the latter with tubules in the teeth, but not to the fully-expressed extent seen in the fossils from Córcoles and the molars retain a distinct and large pulp cavity, …